THE APPLICATION OF THE ENTEROSORBENT AUT FOR THE CORRECTION OF OXIDATION PROCESSES FOR EXPERIMENTAL COLORECTAL CARCENOGENESIS IN RATS
DOI:
https://doi.org/10.11603/1811-2471.2019.v.i3.10438Keywords:
oxidative stress, antioxidant system, dimethylhydrazine, enterosorbent AUT, oxidative modification of the proteinAbstract
SUMMARY. Malignant neoplasms of the colon are one of the most common diseases of the gastrointestinal tract. The process of tumor development is accompanied by hyperfunction of reactive oxygen species with subsequent violation of the body’s antioxidant protection. Therefore, in addition to antitumor therapy, the use of accompaniment therapy, in particular, enterosorption.
The aim of the study – to evaluate the efficacy of using enterosorbent AUT and its effect on oxidative stress in rats affected by 1,2-dimethylhydrazine.
Material and Methods. The experiments were performed on white male rats, who modeled colon cancer by weekly subcutaneous administration of 1,2-dimethylhydrazine at a dose of 7.2 mg/kg body weight for 30 weeks. Enterosorbent AUT was administered intragastrically daily for 21 days after modeling of carcinogenesis at a dose of 1 ml of suspension (corresponding to 0.2 g net weight of the preparation) per 100 g of body weight of the animal. The development of oxidative stress was studied by the activity of protein oxidative modification, the concentration of products of lipid peroxidation (LPO) by the activity of superoxide dismutase (SOD), catalase.
Results. It was established that oxidative stress develops during carcinogen administration of 1,2-dimethylhydrazine hydrochloride. In experimental animals, the peroxidant and antioxidant balance is disturbed, accompanied by a decrease in the antioxidant system. The use of enterosorbent AUT contributed to the normalization of these indicators.
Conclusions. The results confirm the positive dynamics of the use of detoxification therapy with sorbent AUT during the progressive development of oxidative stress under the conditions of simulated carcinogenesis.
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