INFLUENCE OF HYPOTHYROIDISM ON THE DYNAMICS OF METABOLIC AND HORMONAL STATUS IN MEN
DOI:
https://doi.org/10.11603/1811-2471.2019.v0.i2.10384Keywords:
hypothyroidism, reproductive hormones, testosterone, metabolic status, follicle stimulating hormone, luteinizing hormoneAbstract
Violations in the endocrine system of men with hypothyroidism contribute to the development of hypogonadism and the weakening of fertility due to the apparent linkage of reproductive hormones and spermatogenesis.
The aim of this study was to assess the hormonal status, metabolic and anthropometric indexes in men of active reproductive age with primary hypothyroidism.
Material and Methods. A comparative analysis of hormonal, anthropometric and metabolic parameters in 60 men with hypothyroidism and 25 men without hypothyroidism (control group) was conducted.
Results. It was found that for the group of men with hypothyroidism, in comparison with the control group, more common were increase in total cholesterol and low density lipoprotein, as well as a decrease in testosterone levels and an increase in follicle-stimulating hormone, while other reproductive hormones such as estradiol and luteinizing hormones were not changed. It is believed that in men suffering from hypothyroidism, lowering the testosterone level and increasing the follicle stimulating hormone is the primary index which indicates the development of functional hypogonadism, which ultimately leads to a decrease in libido, erectile dysfunction and subfertility.
Conclusions. Men with hypothyroidism were shown to lower testosterone levels and increase the level of follicle stimulating hormone in the blood, which is 63 % higher than in the control group. In 97 % of men with hypothyroidism, there was an increase in blood levels of total cholesterol and cholesterol of low density lipoproteins.
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