SIGNIFICANCE OF LIPOPEROXIDATION PROCESSES AND ACTIVITY OF ANTIOXIDANT SYSTEM IN THE MYOCARDIUM UNDER THE CONDITIONS OF DEVELOPMENT OF ADRENALINE MYOCARDIAL DAMAGE DURING EXPERIMENTAL PERIODONTITIS AND CORRECTION OF THEIR DISORDERS WITH COVARIATE
DOI:
https://doi.org/10.11603/1811-2471.2019.v0.i2.10375Keywords:
adrenaline injury of myocarditis, periodontitis, corvitin, antioxidant systemAbstract
The significance of lipid peroxidation and antioxidant activity are some of the factors that can affect the development and progression of both adrenaline injury of myocarditis (AIM) and periodontitis. However, in the literature, we found no reports of value indicators such as diene conjugates (DC), malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CT) and ceruloplasmin (CP) under AIM comorbidity and periodontitis, and methods of correction of corvitin.
The aim of the study – to evaluate the values of lipid peroxidation and antioxidant system activity in the myocardium under the conditions of epinephrine myocardial damage during experimental periodontitis before and after corvitin correction.
Materials and Methods. Experiments were conducted on 54 white male rats, which were divided into six groups (9 animals in each). Group 1 – the control, groups 2, 3, 4 and 5 – the group of animals with AIM during the course of experimental periodontitis (EP), accordingly, in the 1-st, 7-th, 10-th and 17-th days of the experiment without correction of corvitin and group 6, accordingly, on the 17-th day – animals with AIM and during EP with the course of correction of corvitin. During the experiment, the tissue of the myocardium of rats was collected and evaluated the content of diene conjugates (DC), malonic dialdehyde (MDA), superoxide dismutase (SOD), catalase (CT), ceruloplasmin (CP) was measured.
Results. In animals with a combined pathology of AIM and periodontitis without correction of corvitin, the results showed an increase in the indications of diene conjugates and malonic dialdehyde and decrease of superoxide dismutase, catalase and ceruloplasmin. And with these combined pathologies with their corvitin correction established the opposite – a decrease in the indices of diene conjugates and malonic dialdehyde and the growth of superoxide dismutase, catalase and ceruloplasmin.
Conclusion. In experimental rats with a combined course of AIM and periodontitis there is a more intensive development of oxidative stress, which may be a manifestation of the strengthening of two combined pathologies, especially without correction of corvitin. However, the correction with a drug with antioxidant properties showed a decrease in the development of oxidative stress, an increase in the antioxidant protection and a decrease in the accumulation of products of peroxide lipid oxidation (PLO).
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