FEATURES OF LIPID METABOLISM IN OVERWEIGHT AND OBESE ADOLESCENTS DEPENDING ON THE VARIOUS LEVELS OF VITAMIN D
DOI:
https://doi.org/10.11603/1811-2471.2019.v0.i2.10367Keywords:
vitamin D, obesity, calcidiol, cardiometabolic risk, adolescentsAbstract
Vitamin D deficiency and overweight have now become an important global problem in the field of health care as well as public health. A substantial hypovitaminosis D in children with obesity is often accompanied by metabolic disorders.
The aim of the study was to determine the relationship between the levels of vitamin D and lipid metabolism markers in adolescents with overweight and obesity.
Material and methods. 139 adolescents were examined (63 (45.4 %) girls and 76 (54.7 %) boys). Depending on the body mass index (BMI) 65 children were overweight and 74 were obese children. The mean age of teenagers was (15,4±2,3) years. To establish vitamin D status using the immune-enzyme method, blood serum levels of 25(OH)D were determined. Lipid metabolism markers were determined using the Roche Diagnostics Cholesterol reagent kit using and automatic Cobas c111 analyzer.
Results. The study established a direct relationship between the level of vitamin D and high-density lipoprotein cholesterol and indirect with total cholesterol, triglycerides, low-density lipoprotein cholesterol, atherogenic index, body mass index and waist circumference. Using a simple linear regression analysis, it was determined that total cholesterol, low-density lipoprotein cholesterol and atherogenic index have the greatest correlation with vitamin D.
Conclusions: Vitamin D deficiency in overweight and obese adolescents is associated with an increase in the body mass index, blood pressure, and atherogenic dyslipidemia.
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