MICROBIOLOGICAL FEATURES OF BACTERIAL VAGINOSIS IN WOMEN OF DIFFERENT AGE CATEGORIES AND WAYS OF THEIR MICROBIOLOGICAL CORRECTION
DOI:
https://doi.org/10.11603/1811-2471.2019.v.i3.10258Keywords:
conditionally pathogenic microflora, dysbiosis, bacterial vaginosis, gardnerellaAbstract
SUMMARY. Today’s data indicate that bacterial vaginosis is a widespread clinical syndrome of vaginal microflora in women. Infectious-inflammatory diseases of the female genital system, which occur on the background of bacterial vaginosis, form a serious danger to the body. Development of diseases of the pelvic organs of microbial etiology depends on the persistent properties of microorganisms aimed at inactivating factors of the natural resistance of the organism.
The aim – to study scientific literary sources, which highlight the problem of the composition of microflora in vaginal dysbiosis, and the ways of their microbiological correction; determine the most frequent forms of dysbiotic states, pathogens and their effects on the body of women.
Results and Discussion. Vaginal dysbiosis is a polyetiological state, not only such Gardnerella vaginalis is involved in its development, but also Anaerobes Mobiluncus spp., Bacteroides spp., Mycoplasma hominis, and others. The only reason for the emergence of bacterial vaginosis is the violation of the quantitative composition of the microorganisms of the vaginal environment against the background of other dysbiotic processes of the organism. Complications associated with bacterial vaginosis include chronic inflammatory processes of the internal genital organs, the development of adhesive processes of the pelvic organs, infertility, the unauthorized termination of pregnancy at various times, in addition, BV agents can affect the development of malignant tumors. To a large extent, dysbiosis is associated with certain difficulties in diagnosis, resistance to treatment, extremely high prevalence and the possibility of developing severe complications, especially those that affect the reproductive function of a person.
Conclusions. Thus, vaginal microflora is not a static but an evolving macro-population, in which the number of certain types of microorganisms fluctuates within changes in the conditions of their habitat. This dynamic state of the microflora of the vagina is not always taken into account when analyzing the results of bacteriological studies. Consequently, this problem requires a more detailed study of the pathogenetic mechanisms and ways of drug correction of this condition, which will be the subject of our further research.
References
Volkov, T.A., & Bolshakova, H.M. (2009). Mikroflora pikhvy u zhinok reproduktyvnoho viku v normi i pry riznii patolohii [Violet microflora in women of reproductive age in normal and with different pathology]. Annaly Mechnykovskogo instytutu –– Annals of the Mechnikov Institute, (1) 5-13 [in Ukrainian].
Borys, O.M., Sumenko, V.V., Onyshchyk, L.M., Hak, I.O., Malysheva, I.V., Bondaruk, O.Ya., & Serbeniuk, A.V. (2012). Suchasnyi pidkhid v likuvanni mikst-infektsii u zhinok reproduktyvnoho viku z fonovymy protsesamy shyiky matky [Modern approach in the treatment of mixed infection in women of reproductive age with background processes of the cervix]. Zdorovye zhenshchiny – Health of a Woman (1) 43-49 [in Ukrainian].
Korshunov, V.M, Gudiyeva, Z.A., & Yefimov, B.A. (1999). Izucheniye bifidoflory vlagalishcha u zhenshchin reproduktivnogo vozrasta [Study of vaginal bifidoflora in women of reproductive age]. ZH. Mikrobiol – Journal of Microbiology, (4) 74-78 [in Russian].
Diudiun, A.D., & Kruzhnova, O.V. (2013). Kompleksne likuvannia khvorykh na bakterialnyi vahinoz z urakhuvanniam mikrobiotychnykh ta imunnykh porushen [Complex treatment of patients with bacterial vaginosis taking into account microbiotic and immune disorders]. Dermatovenerolohiia. Kosmetolohiia. Seksopatolohiia – Dermatovenerology. Cosmetology. Sexual pathology, (1-4) 21- 29 [in Ukrainian].
Andrukh, V.C. (2013) Mikrobiota. Liudyna. Dysbakterioz. Bakterialni probiotyky. Pravda ta mify [Microbiota. Man. Dysbiosis. Bacterial probiotics. Truth and myths]. Meditsynskie aspekty zdorovya muzhchyny – Medical Aspects of Man’s Health (3) 65-69 [in Ukrainian].
Lusta, M.V. (2018). Femoflor skrin yak metod diahnostyky dysbakteriozu urohenitalnoho traktu zhinok reproduktyvnoho viku [Femoflore screen as a method of diagnosis of dysbiosis in the urogenital tract of women of reproductive age]. Khyst: vseukrainskyi medychnyi zhurnal molodykh vchenykh – HIST: Allukrainian Medical Journal of Young Scientists (20), 212 [in Ukrainian].
Burmenskaya, O.V. (2014). Vidovoy sostav laktobakteriy pri nespetsificheskikh vaginitakh i bakterialnom vaginoze i yego vliyaniye na lokalnyy immunitet [The species composition of lactobacilli in non-specific vaginitis and bacterial vaginosis and its effect on local immunity]. Akusherstvo i ginekologiya – Obstetrics and Gynecology (1) 41-44 [in Russian].
Letyayeva, O.I. (2014). Terapiya retsidiviruyushchego bakterialnogo vaginoza: kliniko-mikrobiologicheskiye aspekty [Therapy of recurrent bacterial vaginosis: clinical and microbiological aspects]. Akusherstvo i ginekologiya – Obstetrics and Gynecology (4), 88-92 [in Russian].
Van Nan (2017). Profilaktika retsidiviruyushchego bakterialnogo vaginoza na osnove vosstanovleniya kolonizatsionnoy rezistentnosti laktobakteriy yestestvennymi fizicheskimi faktorami [Prevention of a recurrent bacterial vaginosis on the basis of restoration of colonization resistance of lactobacilli by natural physical factors]. Candidate’s thesis [in Russian].
Tertyshnyk, A.O. (2016). Stan mikrobiotsenozu pikhvy u patsiientok z nespetsyfichnym khronichnym salpihooforytom [The stage of vaginal microbiocenosis in patients with nonspecific chronic salpidogophore]. Neonatolohiia, khirurhiia ta perynatalna medytsyna – Neonatology, Surgery and Perinatal Medicine, VI 1 (19) [in Ukrainian].
Malanchuk, L.M, Malanchuk, S.L., & Nebeso, T.A., (2016). Vahinalna mikrobiota: yak vidnovyty balans pry dysbiozi [Vaginal microbiota: How to restore balance with dysbiosis]. Zdorovye zhenshchiny – Health of a Woman (2), 107-111 [in Ukrainian].
Shelkova, N.H (2009). Mikrobiotsenoz pikhvy zhinok reproduktyvnoho viku ta bakterialnyi vahinoz [Microbiocenosis of vagina of women of reproductive age and bacterial vaginosis]. Korotkyi ohliad bakteriolohichnykh aspektiv. Zbirnyk naukovykh prats spivrobitnykiv NMAPO – A Brief Overview of Bacteriological Aspects. Collection of Scientific Works of NMAPO Employees (17), 1, 921-932 [in Ukrainian].
Boiko, H.B. (2012). Bakterialnyi vahinoz: suchasnyi pohliad na problemu [Bacterial vaginosis: a modern view of the problem]. Ukrainskyi medychnyi chasopys – Ukrainian Medical Journal (5), 91-93 [in Ukrainian].
Tsmur, O.V., Levchuk, O.B., Liashyna, K.V., & Boiko, N.V. (2016). Rezultaty zastosuvannia vitchyznianoho synbiotyku Bifiten dlia terapii bakterialnykh vahinoziv u vahitnykh [Results of application of domestic synbiotics Bifitin for the treatment of bacterial vaginosis in pregnant women]. Zdorovye zhenshchiny –Women’s Health (6), 66-72 [in Ukrainian].
Nitsovych, I.R., & Semeniak, A.V. (2016). Osoblyvosti perebihu ta likuvannia bakterialnoho vahinozu u vahitnykh [Features of the course and treatment of bacterial vaginosis in pregnant women]. Bukovynskyi derzhavnyi medychnyi universytet – Bukovinian State Medical University, (3) 61-64 [in Ukrainian].
Ananyeva, M.M. (2018). Etiologicheskiye i patogeneticheskiye aspekty nespetsificheskogo bakterialnogo vaginoza [Etiological and pathogenetic aspects of nonspecific bacterial vaginosis]. Zaporozhskiy meditsinskiy zhurnal – Zaporozhye Medical Journal, 20 (3) [in Russian].
Turkevych, O.Yu. (2011). Kompleksne likuvannia zhinok z bakterialnym vahinozom na tli herpesvirusnoi ta papilomavirusnoi infektsii z urakhuvanniam stanu pikhvovoho mikrobiotsenozu ta imunolohichnoho statusu khvorykh [Complex treatment of women with bacterial vaginosis against the background of herpesvirus and papillomavirus infection taking into account the condition of vaginal microbiocenosis and immunological status of patients]. Ukr. zhurn. dermatol., venerol., kosmetol – Ukrainian Journal of Dermatol., Venerology, Cosmetology, (1) 89-96 [in Ukrainian].
Zalizniak, V.O. (2015). Zapalni zakhvoriuvannia zhinochykh statevykh orhaniv [Inflammatory diseases of female genital organs]. Zaporizhzhia: ZDMU [in Ukrainian].
Vdovychenko, Yu.P., & Hopchuk, O.M. (2016). Bakterialnyi vahinoz – monoterapiia kombinovanymy preparatamy [Bacterial vaginosis – monotherapy with combined drugs]. Zdorovye zhenshchiny – Health of Woman (1) [in Ukrainian].
Radzinskiy, V.Ye., Khamoshina, M.B (2011). Korrektsiya narusheniy biotsenoza vlagalishcha: marsh na meste ili dvizheniye vpered? [Correction of violations of the vaginal biocenosis: a march in place or moving forward?]. Doktor.Ru. – Doctor. Ru (9) 26-32 [in Russian].
Rutynska, H.V. (2015). Diahnostyka ta dyferentsiiovana korektsiia vahinalnoho dysbiozu u divchatok prepubertatnoho ta pubertatnoho viku [Diagnosis and differentiated correction of vaginal dysbiosis in girls of prepubertal and pubertal age]. Donetskyi natsionalnyi medychnyi universytet im. M. Horkoho – Donetsk National Medical University by M. Horkyi. Krasnyi Lyman [in Ukrainian].
Hudyvok, I.I., Kolomiitseva, A.H., & Struk, V.F. (2006). Bakterialnyi vahinoz i vahitnist: monohrafiia [Bacterial vaginosis and pregnancy: Monograph]. Kyiv [in Ukrainian].
Sidashenko, O.I., Voronkova, O.S., Sirokvasha, O.A., & Vinnikov, A.I. (2013). Bioplivka yak osoblyva forma orhanizatsii bakterii ta yii rol v infektsiinykh protsesakh [Biofilm as a special form of the organization of bacteria and its role in infectious processes]. Visnyk problem biolohii i medytsyny – Bulletin of Biology and Medicine, (3) 36-41 [in Ukrainian].
Podolskyi, V.V., Lisiana, T.O., & Ponomarova, I.H. (2015). Stan mikrobiotsenozu urohenitalnykh orhaniv u zhinok z porushenniam reproduktyvnoho zdorovia ta zminamy vehetatyvnoho homeostazu [The state of microbiocenosis of urogenital organs in women with reproductive health disorders and changes in vegetative homeostasis]. Zdorovye zhenshchiny – Health of a Women (2) [in Ukrainian].
Hopchuk, O.M. (2015). Bakterialnyi vahinoz – terapevtychnyi pohliad na problemu [Bacterial vaginosis – a therapeutic look at the problem]. Zdorovye zhenshchiny – Health of a Woman, (3), 71-74 [in Ukrainian].
Hopchuk, O.M., & Morozova, O.V. (2015). Stratehii vplyvu na vahinalnyi biotsenoz u zhinok hrup ryzyku [Strategies for influencing vaginal biocenosis in women at risk groups]. Zdorovye zhenshchiny – Health of a Woman (6), 81-83 [in Ukrainian].
Vdovychenko, Yu.P., & Hopchuk, O.M (2016). Bakterialnyi vahinoz – monoterapiia kombinovanymy preparatamy [Bacterial vaginosis – monotherapy with combined drugs]. Zdorovye zhenshchiny – Health of a Woman, 1 (107), 132-136 [in Ukrainian].
Kungurtseva, Ye.A., Popkova, S.M., & Leshchenko, O.Ya. (2014). Vzaimoformirovaniye mikroflory slizistykh obolochek otkrytykh polostey razlichnykh biotopov u zhenshchin kak vazhnyy faktor ikh reproduktivnogo zdorovya [Mutual formation of the microflora of the mucous membranes of the open cavities of various biotopes in women as an important factor in their reproductive health]. Aktualnye voprosy mikrobiologii – Current Issues of Microbiology, 69 (9-10) [in Russian].
Boiko, H.B (2012). Bakterialnyi vahinoz: suchasnyi pohliad na problemu [Bacterial vaginosis: a modern view of the problem]. Ukrainskyi medychnyi chasopys – Ukrainian Medical Journal (5), 91-93 [in Ukrainian]
Parubina, D.Yu. (2018). Osoblyvosti zaproponovanoho alhorytmu vedennia patsiientok reproduktyvnoho viku, khvorykh na leiomiomu matky z riznym typom biotsenozu pikhvy, ta otsinka yoho efektyvnosti [Features of the proposed algorithm for the management of patients of reproductive age, patients with leiomyoma of the uterus with different types of vaginal biocenosis, and evaluation of its effectiveness]. Odeskyi medychnyi zhurnal – Odesa Medical Journal (2), 39-43 [in Ukrainian]
Voropayeva, S.D. (2000). Mikroflora zhenskikh polovykh putey i yeye chuvstvitelnost k antibakterialnym preparatam [The microflora of the female genital tract and its sensitivity to antibacterial drugs]. Antibiotiki i khimioterapiya – Antibiotics and Chemotherapy (3) 4-6 [in Russian].
Prilutskaya, A.B., Kushch, V.N., & Lyanenko, L.A (2016). Sovremennye tendentsii v lechenii bakterialnogo vaginoza [Current trends in the treatment of bacteriological disease]. Health of Woman, 5 (111), 65-66 [in Russian].
Nechyporenko, N.M. (2016) Mikrobiolohichni bioplivky v patohenezi rezystentnosti ta khronizatsii infektsii urohenitalnoho traktu [Microbiological biofilms in the pathogenesis of resistance and chronic infection of the urogenital tract]. Dermatovenerolohiia. Kosmetolohiia. Seksopatolohiia – Dermatovenereology. Cosmetology. Sexual Pathology, 1-2 (3) [in Ukrainian].
Pyrohova, V.I., Malachynska, M.Y., Shurpiak, S.O., & Shchuruk, N.V. (2015). Mikroekolohiia pikhvy – shcho potribno znaty akusheru hinekolohu (klinichna lektsiia) [Microecology of the vagina – what gynecologist obstetrician need to know (clinical lecture)]. Zdorovye zhenshchiny – Women’s Health, 7 (103) [in Ukrainian].
Voroshilina, Ye.S., Plotko, Ye.E., & Zornikov, D.L. (2017). Normalnoye sostoyaniye mikrobiotsenoza vlagalishcha: otsenka s subyektivnoy, ekspertnoy i laboratornoy tochek zreniya [The normal state of the vaginal microbiocenosis: assessment from the subjective, expert and laboratory points of view]. Vestnik RGMU Nauchnyy meditsinskiy zhurnal imeni N.I. Pirogova – Russian State Medical University Journal by N.I. Pirogov, (2), 42-46 [in Russian].
Tuchkina, I.O., Vyhivska, L.A., & Demydenko, O.D. (2014). Likuvannia vulvovahinalnykh infektsii zhinochoi statevoi systemy v rizni vikovi periody [Treatment of vulvovaginal infections of the female genitalia in different age periods]. Kharkiv: KhNMU [in Ukrainian].
Statya iz gazety (2014). Bakterialnyy vaginoz: prichiny, simptomy i profilaktika zabolevaniya [Bacterial vaginosis: causes, symptoms and prevention of the disease]. Lekarstvennyy spravochnik – Drug Handbook, (3) 27/01 [in Russian].
Diudiun, A.D., Kruzhnova, O.V., & Hladyshev, V.V. (2013). Kompleksne likuvannia khvorykh na bakterialnyi vahinoz z urakhuvanniam mikrobiotychnykh ta imunnykh porushen [Complex treatment of patients with bacterial vaginosis taking into account microbiotic and immune disorders]. Dermatovenerolohiia. Kosmetolohiia. Seksopatolohiia – Dermatovenereology. Cosmetology. Sexual Pathology, (1-4), 28 [in Ukrainian].
Melkumyan, A.R., & Priputnevich, T.V. (2013). Vlagalishchnyye laktobakterii – sovremennyye podkhody k vidovoy identifikatsii i izucheniyu ikh roli v mikrobnom soobshchestve [Vaginal lactobacilli – modern approaches to species identification and the study of their role in the microbial community]. Akusherstvo i ginekologiya – Obstetrics and Gynecology, (7), 18-23 [in Russian].
Tuchkina, I.A., & Tysiachka, H.M. (2013). Bakterialnyi vahinoz yak faktor vysokoho ryzyku porushennia reproduktyvnoho zdorovia v molodomu vitsi [Bacterial vaginosis as a high risk factor for reproductive health in a young age]. Zdorovye zhenshchiny – Health of a Woman, (9), 110-115[in Ukrainian].
Shelkova, N.H. (2009). Mikrobiotsenoz pikhvy zhinok reproduktyvnoho viku ta bakterialnyi vahinoz. Korotkyi ohliad bakteriolohichnykh aspektiv [Microbiocenosis of vagina of women of reproductive age and bacterial vaginosis. A brief overview of bacteriological aspects]. Zbirnyk naukovykh prats spivrobitnykiv NMAPO – Collection of Scientific Papers of the NMAPO staff. Kyiv [in Ukrainian].
Kira, Ye.F., & Muslimova, S.Z. (2008). Nespetsificheskiy vaginit i yego vliyaniye na reproduktivnoye zdorovye zhenshchiny [Non-specific vaginitis and its effect on the reproductive health of women]. Problemy reproduktsii – Problems of Reproduction, (5), 8-14 [in Russian].
Adaskevych, V.P. (2001). Infektsii, shcho peredaiutsia statevym shliakhom [Sexually transmitted infections]. Medychna knyha – Medical Book, 189-201 [in Ukrainian].
Voronin, K.V., Nakhla, B.S., & Chuiko, V.I. (2012). Bakterialnyy vaginoz beremennykh: etiologicheskaya diagnostika, prognozirovaniye i printsipy aktivnoy profilaktiki infektsionnykh i perinatalnykh oslozhneniy [Bacterial vaginosis of pregnant women: etiological diagnosis, prognosis and principles of active prevention of infectious and perinatal complications]. Tavrich. med.-biolog. vestn. – Tavrich Medical Biological Bulletin, 15 (2), 40-43 [in Russian].
Dubynyna, V.T., Marchenko, A.O., Lukianchuk, O.V., Rybin, A.O. (2018) Klinichnyi dosvid zastosuvannia preparativ “Meratyn” i “Meratyn-kombi” dlia likuvannia ta profilaktyky bakterialnoho vahinozu [Clinical experience of the use of drugs “Meratin” and “Meratin-combi” for the treatment and prophylaxis of bacterial vaginosis]. Zhinochyi likar – Woman’s Doctor, (3), 39-42 [in Ukrainian].
Tatarchuk, T.F. (2015). Sovremennyy podkhod k terapii nespetsificheskikh vaginitov (obzor konferentsii) [Modern approach to the treatment of nonspecific vaginitis (conference review)]. Zdorovye zhenshchiny – Women’s Health, (7), 126-129 [in Russian].
Konoplya, A.A., Karaulov, A.V., & Yudina, Ye.A. (2008). Mestnyy immunitet pri khronicheskom salpingooforite: korrektsiya narusheniy longidazoy [Local immunity in chronic salpingoophoritis: correction of violations by longidaza]. Rossiyskiy immunologicheskiy zhurnal – Russian Immunological Journal, (2) 195 [in Russian].
Kulakov, V.I. (2002). Sovremennyye printsipy antibakterialnoy terapii v akusherstve i ginekologii [Modern principles of antibiotic therapy in obstetrics and gynecology]. Akusherstvo i ginekologiya − Obstetrics and Gynecology, (2), 3-6 [in Russian].
