FEATURES OF THE CLINICAL COURSE OF GASTROESOPHAGEAL REFLUX DISEASE IN THE LVIV REGION
DOI:
https://doi.org/10.11603/1811-2471.2019.v0.i1.10074Keywords:
gastroesophageal reflux, clinical manifestations, helicobacter infectionAbstract
Gastroesophageal reflux disease is the most common pathology of modern gastroenterology, which causes significant economic and social damage, affects the quality of life of people.
The aim: to investigate the clinical course of gastroesophageal reflux disease.
Material and Methods. A questionnaire, an endoscopic examination of the upper gastrointestinal tract, and a sito test® H. Pylori Ag from Pharmasco® for the diagnosis of helicobacter infection were conducted.
Results. The results of observations on 102 patients with GERD were analyzed: 48 (47.1 %) women and 54 (52.9 %) men. The average age of women was (48±2.11) years, men (37.7±1.65) years. In 73.5 % of the examined patients, the endoscopically positive form of GERD was diagnosed, while 26.5 % had no erosive-ulcerative changes in the esophagus mucosa. Study of lifestyle communication in patients with GERD showed that irregular nutrition and smoking contribute to the development of the disease. Analysis of the main complaints showed that in 37.2 % of patients with heartburn, daily, periodic heartburn 3–4 times a week was noted by 62.7 % of patients. Bloating and morning vomiting were observed in 59.8 % and 16.7 % of patients respectively. Nausea was noted by 37.2 % of the surveyed. An unpleasant taste in the mouth complained 35.3 % of patients. Epigastric pain was observed in 53.9 % of cases. 27.5 % of patients with GERD were infected with H. pylori.
Conclusions. 1. It was established that the endoscopically negative form of GERD is 4 times more often diagnosed in women, while erosive changes in the mucous membrane of the esophagus are twice as high among males. It was found that most often GERD was diagnosed in young and middle age (48.1 % and 19.1 % respectively).
- It was shown that the risk factors for GERD are irregular diet and smoking. Instead, the helicobacter infection is not associated with GERD, regardless of the endoscopic pattern.
- It was found that daily heartburn, nausea and an unpleasant taste are more common in patients with endoscopically negative GERD (55.6 %, 62.9 %, 77.7 % respectively), a combination of periodic heartburn, burping and pain in the epigastrium can be suspected of having erosive-ulcerative changes in the esophagus mucosa.
References
Babak, O.Ya. (2014). HERKh. Vid teorii do praktyky [GERD. From theory to practice]. Suchasna hastroenterolohiia – Modern Gastroenterology, 4 (78), 38-44 [in Ukrainian].
Babak, M.O. (2011). Poshyrenist typovykh ta atypovykh proiaviv hastroezofahealnoi refliuksnoi khvoroby [The prevalence of typical and atypical manifestations of gastroesophageal reflux disease]. Ukr. terapevt. zhurn. – Ukrainian Therapeutic Journal, 2, 33-37 [in Ukrainian].
Blondeau, K. (2010). Treatment of gastroesophageal reflux disease:the new kids to block. Neurogastroenterol. Motil., 22, 836-840.
Nazarian, R.S., Yemelianova, N.Yu., Karnaukh, O.V., & Khmyz, T.H. (2013). Stomatolohichni proiavy hastroezofahealnoi refliuksnoi khvoroby u ditei ta doroslykh. Ohliad literatury [Dental displays of gastroesophageal reflux disease in children and adults. Literature review]. Profilaktychna ta dytiacha stomatolohiia – Preventive and Pediatric Dentistry, 2 (9), 34-39 [in Ukrainian].
Zvenigorodskaya, L.A., & Churikova, A.A. (2012). Terapiya gastroezofagelnoy reflyuksnoy bolezni pri ishemicheskoy bolezni serdtsa [Therapy of gastroesophageal reflux disease in coronary heart disease.]. Klin. geront. – Clinical Gerontology, 18, 48-51 [in Russian].
Kahrilas, P.J. (2004). Review article: gastroesophageal reflux disease as a functional gastrointestinal disorder. Aliment. Pharmacol Iher., 20 (Suppl), 50-55.
Kamenir, V.M. (2010). Dynamika rivnia stabilnykh metabolitiv oksydu azotu i melatoninu u patsiientiv z hastroezofahalnoiu refliuksnoiu khvoroboiu u poiednanni z khronichnym obstruktyvnym zakhvoriuvanniam lehen na tli likuvannia melatoninom [Dynamics of the level of stable metabolites of nitric oxide and melatonin in patients with gastroesophageal reflux disease in combination with chronic obstructive pulmonary disease on the background of treatment with melatonin]. Suchasna hastroenterolohiia – Modern Gastroenterology, 4, 61-66 [in Ukrainian].
Kellerman, R., & Kintanar, T. (2017). Gastroesophageal reflux disease. Prim. Care, 44 (4), 561-573. doi: 10.1016/j.pop.2017.07.001. Epub 2017 Oct 5. Review. PubMed PMID: 29132520.
Kseneva, S.I., Borodulina, E.V., & Udut, V.V. (2018). Discoordination of autonomic support of functions in the pathogenesis gastroesophageal reflux disease. Bull. Exp. Biol. Med. doi: 10.1007/s10517-018-4279-3. [Epub ahead of print] PubMed PMID:30450517.
Maev, I.V. (2004). Gastroezofagelnaya reflyuksnaya bolezn – bolezn ХХІ veka [Gastroesophageal reflux disease – a disease of the XXI century]. Lechashchii vrach – Attending Doctor, 4, 10-14 [in Russian].
Vdovychenko, V.I., & Sverdan, Ya.P. (2013). Kardiolohichni symptomy hastroezofahealnoi refliuksnoi khvoroby u patsiientiv iz tsukrovym diabetom 2 typu [Cardiological symptoms of gastroesophageal reflux disease in patients with diabetes mellitus type 2]. Suchasna hastroenterolohiia – Modern Gastroenterology, 3 (71), 110-114 [in Ukrainian].
Palii, I.H., Zaika, S.V., & Yankovetska, A.H. (2014). Poshyrennia HERKh sered khvorykh z patolohiieiu orhaniv travlennia, provokuiuchi chynnyky ta efektyvnist blokatoriv N+/K+ATFazy (za rezultatamy anketuvannia ambulatornykh khvorykh) [Distribution of GERD among patients with pathology of digestive organs, provocative factors and the effectiveness of N + / K + ATPase blockers (based on the results of the survey of ambulatory patients)]. Suchasna hastroenterolohiia – Modern Gastroenterology, 4 (78), 38-44 [in Ukrainian].
Ostrohliad, A.V. (2006). Pershyi dosvid vyvchennia epidemiolohii hastroezofahealnoi refliuksnoi khvoroby v Ukraini [The first experience of epidemiology of gastroesophageal reflux disease in Ukraine]. Suchasna hastroenterolohiia – Modern Gastroenterology, 1 (27), 30-32 [in Ukrainian].
Babak, M.O. (2011). Henderni osoblyvosti poshyrenosti hastroezofahealnoi refliuksnoi khvoroby [Gender features of the prevalence of gastroesophageal reflux disease]. Suchasna hastroenterolohiia – Modern Gastroenterology, 3, 11-16 [in Ukrainian].
Bychkov, M.A. (2011). Klinichni osoblyvosti perebihu zakhvoriuvan stravokhodu u patsiientiv revmatolohichnoho profiliu [Clinical features of the course of diseases of the esophagus in patients with rheumatoid profile]. Ukrainskyi revmatolohichnyi zhurnal – Ukrainian Rheumatological Journal, 3, 75-78 [in Ukrainian].
Bychkov, M.A., & Yakhnytska, M.M. (2017). Poshyrenist hastroezofahealnoi refliuksnoi khvoroby za danymy endoskopichnykh doslidzhen [Prevalence of gastroesophageal reflux disease according to endoscopic studies]. Zdobutky klinichnoi i eksperymentalnoi medytsyny – Achievements of Clinical and Experimental Medicine, 2, 38-43 [in Ukrainian].
Bychkov, M.A., Savytskyi, Ya.M., Shvydkyi, Ya.B., & Yakhnytska, M.M. (2017). Henderni ta vikovi osoblyvosti endoskopichno pozytyvnoi formy hastroezofahealnoi refliuksnoi khvoroby [Gender and age characteristics of the endoscopically positive form of gastroesophageal reflux disease]. Aktualni problemy suchasnoi medytsyny – Actual Problems of Modern Medicine, 17 (4), 72-76 [in Ukrainian].
Krylova, O.O., Maikova, T.V., Kutniak, V.M., & Yershova, S.Iu. (2016). Endoskopichna diahnostyka hastroezofahealnoi refliuksnoi khvoroby [Endoscopy diagnosis of gastroesophageal reflux pain]. Suchasna hastroenterolohiia – Modern Gastroenterology, 6 (92), 109-118 [in Ukrainian].
