CHANGES OF MAIN INDICATORS OF RED BLOOD IN PATIENTS WITH STEATOHEPATITIS OF DIFFERENT ETIOLOGIES
DOI:
https://doi.org/10.11603/1811-2471.2019.v0.i1.10066Keywords:
non-alcoholic steatohepatitis, alcoholic steatohepatitis, anemic syndrome, obesityAbstract
The main causes of liver steatohepatitis are exposure to toxic substances, endocrine disorders, and poor diet. A special place among toxic agents is alcohol.
The aim – to investigate changes in the main indicators of red blood with steatohepatitis of various etiologies.
Material and Methods. A clinical observation of 60 patients with alcoholic liver disease and non-alcoholic steatohepatitis was conducted. Among surveyed, 53.3 % were men, 46.7 % were women. All patients were divided into two groups: the group I accounted for 33 % of patients with alcoholic liver disease (alcoholic steatohepatitis – ASH), the group II – 67 % of patients with non-alcoholic fatty liver disease (nonalcoholic steatohepatitis – NASH). The control group consisted of 20 practically healthy individuals, in whom no acute or chronic diseases or allergic reactions were detected.
Results. In the study of the clinical blood analysis, it was found that the content of erythrocytes in the peripheral blood of NASH patients was within the normal range, and in patients with ASH, this indicator was significantly lower than that of the PEP by 9.0 % (p<0.05). At the same time, the hemoglobin content in patients of the same group was significantly different from the age norm and was significantly lower than in practically healthy individuals by 8.5 % (p <0.05), and this indicates that some patients with ASH have anemic syndrome.
Conclusion. The course of alcoholic steatohepatitis in 25.0 % of cases is accompanied by an anemic mild syndrome, despite a significant increase in serum iron content, ferritin, transferrin saturation with iron. Moreover, in 15.0 % of patients with ASH, anemia is caused by vitamin B12 deficiency, and in 10.0 % – by erythrocyte hemolysis. It is described that on the background of obesity, non-alcoholic steatohepatitis is characterized by an unreliable increase in serum iron content, ferritin content and transferrin saturation with iron in the absence of clinical and laboratory signs of anemia.
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