CLINICAL AND LABORATORY EVALUATION OF THE EFFICIENCY OF TREATMANT OF THE IRRITABLE INTESTINE SYNDROME IN PATIENTS WITH OBESITY
DOI:
https://doi.org/10.11603/1811-2471.2019.v0.i1.10065Keywords:
irritable bowel syndrome, obesity, treatment, phosphorus, salivaAbstract
Irritable bowel syndrome (IBS) is among the most common functional diseases of the digestive system. Despite active research in recent years, the mechanisms of development of the IBS and the effectiveness of its treatment are remained quite low.
The aim of the study – to analyze the results of the treatment of IBS in patients with obesity with Laktimak Forte using clinical indicators and the phosphorus content in saliva.
Material and Methods. 22 patients with IBS and obesity were examined. The features of the clinical course of comorbid pathology are analyzed. The samples of saliva of all patients were additionally analyzed. All data were statistical processed.
Results. After the treatment of patients with obesity, the clinical manifestations of IBS were significantly decreased and the stools were normalized. Patients noted good tolerability of Laktimak Forte. Side effects associated with taking the drug were not detected. It was established that in patients with comorbid pathology, the level of inorganic phosphorus in saliva was significantly reduced. It was established a significant increasing in the content of inorganic phosphorus in the saliva after the treatment, which may probably indicate both an improvement in the homeostasis of the gastrointestinal tract and the electrolyte composition of saliva.
Conclusions. It is established that the combined drug Laktimak Forte showed a positive clinical effect without side effects in patients with IBS and obesity. It was revealed the significant changes in the level of inorganic phosphorus in saliva in patients with IBS and obesity. The estimating of the phosphorus content of saliva in patients with a combination of IBS and obesity was proposed as a simple non-invasive screening method for the early diagnosis of this combination pathology.
References
Dang M. Nguyen, & El Serag Hashem B. (2010) The epidemiology of obesity. Gastroenterol. Clin. North Am., 39 (1), 1-7.
Gahagan S. Overweight and obesity. Nelson textbook of Pediatrics. Kliegman, R.M., Stanton, B.F., St. Geme, J.W., Schor, N.F. (Eds). 20th ed. Philadelphia, PA: Elsevier.
Wang, Y., Beydoun, M.A., & Liang, L. (2008). Will all Americans become overweight or obese? Estimating the progression and cost of the US obesity Epidemic. Obesity.,16 (10), 2323-2330.
Diachuk, D.D. (2017). Ozhyrinnia u ditei: faktory ryzyku ta rekomendatsii z profilaktyky [Obesity in children: Risk factors and prevention recommendations]. Sovremennaya pediatriya – Modern Pediatrics, 2 (82), 42-46 [in Ukrainian].
Zhuravleva, L.V., Lahno, O.V., & Tsivenko, O.I. (2014). Likuvannia kyslotozalezhnykh zakhvoriuvan u patsiientiv iz metabolichnymy porushenniamy [Treatment of acid-dependent diseases in patients with metabolic disorders]. Suchasna hastroenterolohiia – Modern Gastroenterology, 3 (77), 42-45 [in Ukrainian].
Platonova, O.M., & Velychko, V.I. (2013). Kliniko-patohenetychni paraleli ozhyrinnia ta syndromu podraznenoho kyshechnyku u ditei [Clinical and pathogenetic parallels of obesity and irritable bowel syndrome in children]. Klinichna ta eksperymentalna patolohiia – Clinical and Experimental Pathology, 2 (44), 144-146 [in Ukrainian].
Palii, I.H., & Zaika, S.V. (2017). Syndrom podraznenoho kyshechnyka: aktualnist problemy ta pytannia suchasnoi terapii zhidno z Rymskymy kryteriiamy IV perehliadu [Irritable bowel syndrome: the urgency of the problem and the issue of modern therapy according to Roman criteria IV review]. Suchasna hastroenterolohiia – Modern Gastroenterology, 6 (98), 37-44 [in Ukrainian].
Butorova, L.I., Tokmulin, H.M., & Fin, T.E. (2017). Rimskiye kriterii IV sindroma razdrazhennogo kishechnika: evolyutsiya vzglyadov na patogenez, diagnostiku i lecheniye [Roman criteria for IV irritable bowel syndrome: Evolution of perspectives on pathogenesis, diagnosis, and treatment]. Lechashchiy vrach – Attending Physician, 3, 61-67 [in Russian].
Drossman, D.A. (2016). The functional gastrointestinal disorders: history, pathophysiology, clinical features and Rome IV. Gastroenterol., 150 (6), 1262-1279.
Bychkov, M.A., & Ferents, I.M. (2016). Osoblyvosti perebihu ta likuvannia syndromu podraznenoi kyshky u khvorykh z ozhyrinniam [Peculiarities of the treatment of the syndrome of the syndrome of intestinal intestine in patients with illness]. Aktualni problemy suchasnoi medytsyny: visnyk Ukrainskoi medychnoi stomatolohichnoi akademii – Actual Problems of Modern Medicine: Herald of the Ukrainian Medical Dentistry Academy, 4 (56), 287-291 [in Ukrainian].
Kuro-o M. (2011) Klotho and the Aging Process. The Korean Journal of Internal Medicine, 26 (2), 113-122.
Duda, O.K., Boiko, V.A., Kotsiubailo, L.P., & Okruzhnov, N.V. (2016). Mistse probiotykiv u kompleksnii terapii antybiotykoasotsiiovanoi diarei [Place of probiotics in the complex therapy of antibiotic-associated diarrhea]. Suchasna hastroenterolohiia – Modern Gastroenterology, 6 (92), 85-92 [in Ukrainian].
Lacy, B.E., Mearin, F., & Lin Chang (2016). Bowel disorders. Gastroenterology, 150 (6), 1393-1407.
