DAILY PROFILE OF ARTERIAL PRESSURE AND COGNITIVE DISTURBANCE
DOI:
https://doi.org/10.11603/1811-2471.2019.v0.i1.10063Keywords:
hypertension, cognitive impairment, diurnal blood pressure profileAbstract
The relationship between high blood pressure (BP) and cognitive impairment has attracted particular attention in recent decades. Nowadays, there are not enough data about the effect of diurnal blood pressure profile on cognitive function.
The aim of the study – to analyse the relationship between circadian BP pattern and cognitive function in patients with hypertensive disease.
Material and Methods. To this purpose, we selected 45 hypertensives with arterial hypertension 2–3 degrees (the average level of systolic and diastolic BP was (169±9) and (96±7). Hypertensive subjects were subdivided in three groups: dippers (n=20), non-dippers (n=14), and hyper-dippers (n=11) according to a nocturnal fall of blood pressure. Neuropsychological examination was carried out by Mini-Mental State Examination (MMSE).
Results. It was found that 70 % of dippers had cognitive disorders, among nondippers cognitive disorders were detected in 93 % and among hyper-dippers – in 100 %. Light cognitive impairments predominated in structure among dippers and nondippers, whereas mild cognitive impairments predominated among hyper-dippers. Significant differences between hyper-dippers and dippers were found in the MMSE scores ((25.9±1.3) and (26.8±2.7), p<0.05).
Conclusions. Cognitive disorders were found in three groups of hypertension patients, however, hyper-dipping pattern was associated with lower cognitive function.
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