FEATURES OF ACID-PRODUCTION FUNCTION OF THE STOMACH IN PATIENTS WITH CHRONIC GASTRITIS AND DIABETES MELLITUS TYPE 2
DOI:
https://doi.org/10.11603/1811-2471.2019.v0.i1.10062Keywords:
type 2 diabetes mellitus, chronic gastritis, Helicobacter pyloriAbstract
Due to the high morbidity and mortality associated with Helicobacter pylori (HP) induced diseases, considerable efforts were made to determine the precise mechanisms by which this pathogen causes stomach inflammation, although these mechanisms are not sufficiently investigated.
The aim of the study – to evaluate the peculiarities of the acid-forming function of the stomach in patients with chronic gastritis (CG) and type 2 diabetes mellitus (DM) depending on the presence or absence of Helicobacter pylori (HP).
Material and Methods. We examined 80 patients with an average age of (57.6±2.3) years. This study was conducted with the participation of 45 (56.3 %) women and 35 (43.7 %) men. All patients were divided into two groups depending on the infection with Helicobacter pylori. The group I included 60 (75 %) people who were HP positive, and the group II included 20 (25 %) people – HP negative patients with type 2 diabetes and chronic gastritis.
Results. Patients with DM type 2 and CG, depending on the presence or absence of HP, found a significant difference between the acid-forming function of the stomach. Therefore, patients who are HP positive are more likely to have an acid-forming function in the form of severe hyperacidity (68.3 %), and patients without HP have moderate hyperacidity (75 %).
Conclusions. In most patients with type 2 diabetes and CG with express pH-metria of acid-forming function of the stomach, hyperacid condition was detected.
References
Moodley, Y., Linz, B., Bond, R.P., Nieuwoudt, M., Soodyall, H., Schlebusch, C.M., & van der Merwe, S.W. (2012). Age of the association between Helicobacter pylori and man. PLoS Pathogens, 8 (5).
Ansari, S., & Yamaoka, Y. (2017). Survival of Helicobacter pylori in gastric acidic territory. Helicobacter, 22 (4), 1-13.
Smolka, A.J., & Schubert, M.L. (2017). Helicobacter pylori-induced changes in gastric acid secretion and upper gastrointestinal disease. In Molecular pathogenesis and signal transduction by helicobacter pylori. Springer, Cham., 2, 227-252.
Marcus, E.A., Sachs, G., & Scott, D.R. (2018). Acid-regulated gene expression of Helicobacter pylori: Insight into acid protection and gastric colonization. Helicobacter, 23 (3), 1-19.
Kaparakis-Liaskos, M., & D'Elios, M.M. (2018). Helicobacter pylori: Immune Responses and Gastric Autoimmunity. In the Microbiome in Rheumatic Diseases and Infection. Springer, Cham., 8, 87-96.
Israel, D.A., & Peek, R.M. (2018). Mechanisms of Helicobacter pylori-induced gastric inflammation. Physiology of the Gastrointestinal Tract, 6, 1517-1545.
De Falco, M., Lucariello, A., Iaquinto, S., Esposito, V., Guerra, G., & De Luca, A. (2018). Molecular mechanisms of Helicobacter pylori pathogenesis. Journal of Cellular Physiology, 230 (8), 1702-1707.
