STATUS OF ACID-BASED EQUALITY AND BLOOD VISCOSITY OF RATS AT ACUTE AND CHRONIC POISONING BY ACETYLSALICYLIC ACID AND THEIR INFLUENCE ON STRUCTURAL ORGANIZATION OF LIVER AND KIDNEYS
DOI:
https://doi.org/10.11603/1811-2471.2019.v0.i1.10051Keywords:
acetylsalicylic acid, acidosis, viscosity, liver, kidneys, dystrophyAbstract
The optimal level of acid-base balance is one of the important components that form the body homeostasis. It is also known that metabolic acidosis can develop with overdose of salicylic drugs.
The aim of the study – to determine the level of acidosis and blood viscosity in rats with acute and chronic poisoning with acetylsalicylic acid and their effect on the morphological condition of the liver and kidneys.
Material and Methods. Experiments were carried out on white laboratory rats, which modeled acute and chronic poisoning with acetylsalicylic acid. The studies were conducted by using functional (pH and blood viscosity measurements), histological and statistical methods.
Results. Acute poisoning with acetylsalicylic acid was accompanied by a significant decrease in pH and blood viscosity in rats, resulting in severe organ disorders, which manifested as stagnant venous hypertrophy, capillary stasis with reactive ascending vasoconstriction.
There was also a tendency to decrease the studied blood parameters after 1 day of the experiment in the course of chronic poisoning with acetylsalicylic acid. However, its degree of severity was significantly lower as with acute poisoning. There was stabilization of indicators and even partial compensation of pH after 3 days from the onset of chronic intoxication. However, in the future, the pH level continued to progressively decrease, not reaching the level recorded in acute poisoning. In contrast, the viscosity of blood, on the contrary, gained a tendency to increase.
Detected long-term organ-blood flow disorders led to dystrophic changes in liver and kidney tissues that may be responsible for the development of liver and kidney failure.
Conclusions. 1. Acute poisoning with large doses of acetylsalicylic acid leads to a significant increase in the level of acidosis with at the same time significant decrease in blood viscosity, which may be important links in the pathogenesis of the development of incompatible with life disorders of hemodynamics.
2. Chronic poisoning with acetylsalicylic acid also leads to the gradual development of acidosis, which degree is less pronounced than with acute poisoning and affects the dynamics of blood viscosity.
3. Disorders of organ blood flow that arise from chronic poisoning with acetylsalicylic acid are less pronounced than with acute poisoning and lead to dystrophic changes in the liver and kidneys which may be responsible for the development of liver and kidney insufficiency.
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