DISORDERS OF THE SYSTEM OF MICROELEMENTS IN PATIENTS WITH CHRONIC PANCREATITIS IN COMBINATION WITH HYPERTENSION
DOI:
https://doi.org/10.11603/1811-2471.2019.v0.i1.10044Keywords:
chronic pancreatitis, hypertonic disease, imbalance of microelementsAbstract
Equilibrium in the system of microelements is an important element of the normal functioning of all organs and systems. Of course, the presence of certain pathological changes contributes to the emergence or progression of disorders in this well-established system. Chronic pancreatitis (CP) and hypertonic disease (HD) are not exception.
The aim of the study – to determine the changes in the microelement composition of blood of patients with CP in conjunction with HD.
Material and Methods. To achieve this goal, we examined 102 patients with CP and HD (main group) and 23 practically healthy patients (control group). In addition to the general clinical trial, the concentration of natrium, calcium, kalium, chlorine, selenium and zincum in blood plasma was determined and the exocrine function of the pancreas (P) was measured for fecal elastase-1 (FE-1) levels.
Results. The patients of the main group had decreased calcium concentration to (2.16±0.26) mmol/l against (2.47±0.18) mmol/l in the group of practically healthy persons, p<0.01), selenium – up to (63.68±18.47) mcg/l, as opposed to (88.16±15.71) mcg/l in group II (p=0.61) zincum – up to (741.05±202.47) mcg/l versus (956.24±172.31) mcg/l in the examined control group (p=0.20). The levels of other microelements studied by us did not go beyond the reference values. In the study of functional capacity, external-secretion insufficiency of the pancreas at the border of the lung and moderate degree was diagnosed ((157.82±17.28) mcg/g faeces).
Conclusions. Diagnosed changes in the composition of microelements require correction in order to achieve homeostasis in the body and prevent the progression and development of complications of CP and HD.
References
Roytberg, G.E., & Strutynskiy, A.V. (2016). Vnutrennye bolezny. Pechen, zhelchevyvodyashchye puti, podzheludochnaya zheleza: ucheb. posobye [Internal illnesses. Liver, biliary tract, pancreas: guide]. Moscow: MEDpress-inform [in Russian].
Yang, D., & Forsmark, C.E. (2017). Chronic pancreatitis. Curr. Opin. Gastroenterol., 5, 396-403.
Pasiieshvili, L.M., Viun, T.I., & Lazutkina, O.A. (2018). Asotsiatsiia metabolichnykh i henetychnykh markeriv ryzyku rozvytku osteopenichnykh staniv pry poiednanni khronichnoho pankreatytu i hipertonichnoi khvoroby [Association of metabolic and genetic markers of the risk of developing osteopenic states in combination of chronic pancreatitis and hypertension]. Zdobutky klinichnoi i eksperymentalnoi medytsyny – The Achievements of Clinical and Experimental Medicine, 2, 81-85 [in Ukrainian].
Skalnyy, A.V. (2004). Khimicheskiye elementy v fiziologii i ekologii cheloveka [Chemical elements in human physioogy and ecology]. Moscow: Mir [in Russian].
Kanzhygalina, Z.K., Kasenova, Z.K., & Oradova, A.Sh. (2013). Biologicheskaya rol i znachenye mikroelementov v zhyznedeyatelnosti cheloveka [The biological role and importance of microelements in human life]. Vestnik KazNMU – Journal of KazNMU, 5 (2), 88-90 [in Russian].
Gubergrits, N.B., & Fomenko, P.G. (2012). Pankreatologiya i “skelet v shkafu” [Pancreatology and the “skeleton in the closet”]. Novyny medytsyny ta farmatsii. Hastroenterolohiia – News of Medicine and Pharmacy. Gastroenterology, 434. Retrived from http://www.mif-ua.com/archive/ article/34349 [in Russian].
Makarova, T.P., & Melnykova, Yu.S. (2018). Endotelialnaya dysfunktsiya i elementnyy status pri khronicheskoy bolezni pochek u detey [Endothelial dysfunction and elemental status in chronic kidney disease in children]. Rossiyskiy vestnik perinatologii i pediatrii – Russian Journal of Perinatology and Pediatrics, 63 (2), 48-52 [in Ukrainian].
Babinets, L.S., & Halabitska, I.M. (2016). Patohenetychni aspekty klinichnoho perebihu khronichnoho pankreatytu: rol pro- i antyoksydantnoho statusu [Pathogenetic aspects of the clinical course of chronic pancreatitis: the role of pro- and antioxidant status]. Zdorovia Ukrainy – Health of Ukraine, 1 (39), 49-51 [in Ukrainian].
Pasiieshvili, L.M., & Morhulis, M.V. (2006). Rol kaltsiiu u formuvanni kliniko-laboratornykh syndromiv pry riznykh variantakh khronichnoho pankreatytu [The role of calcium in the formation of clinical and laboratory syndromes in various variants of chronic pancreatitis]. Suchasna hastroenterolohiia – Modern Gastroenterology, 4 (30), 31-34 [in Ukrainian].
Biletskyi, S.V., Boiko, V.V., Petrynych, O.A., & Kazantseva, T.V. (2017). Endotelialna dysfunktsiia ta arterialna hipertenziia [Endothelial dysfunction and arterial hypertension]. Klinichna ta eksperymentalna patolohiia –Clinical and Experimental Pathology, 1 (59), 160-163 [in Ukrainian].
Buklis, E.R. (2004). Trofologicheskaya nedostatochnost pri boleznyakh organov pishchevareniya [Trophological deficiency in diseases of the digestive system]. Klinicheskiye perspektivy gastroenterologii, gepatologii – Clinical Perspectives of Gastroenterology, Hepatology, 2, 10-15 [in Russian].
Kim, J. (2013). Dietary zinc intake is inversely associated with systolic blood preasure in young obese women. Nutrition Research and Practice, 7 (5), 380-384.
