SYMPTOMATIC EPILEPSY: CAUSES AND PERSPECTIVE METHODS OF TREATMENT
DOI:
https://doi.org/10.11603/1811-2471.2019.v0.i1.10040Keywords:
symptomatic epilepsy, transcranial direct current stimulationAbstract
Epilepsy is one of the most common neuropsychiatric disorders of the central nervous system characterized by repeated spontaneous epileptic seizures. The International League against Epilepsy (ILAE) defines epilepsy as a chronic condition of the brain, which is characterized by an enduring predisposition to generate epileptic seizures and by the neurobiological, cognitive, psychological, and social consequences of this condition, and the definition of epilepsy requires the occurrence of at least one epileptic seizure. The polyetiology and the extraordinary diversity of the clinical manifestations of epilepsy determine the difficulties in its classification. Despite significant scientific advances in neurology, epilepsy remains a significant medical and social problem and there are still no answers to key questions about the mechanisms of epileptic seizures. The search for the optimal treatment that would improve the general condition of the patient with epilepsy, and also helped to minimize other, often harmful, consequences for the social adaptation of such a person, is still ongoing.
The aim – to analyze current views on the problem of symptomatic epilepsy and promising strategies for its treatment.
Conclusion. The results of modern studies on symptomatic epilepsy reveal a number of areas and opportunities for the correction and treatment of this pathology. One of the promising and effective methods of reducing the frequency of seizures and improving the electroencephalographic pattern in patients with symptomatic epilepsy may be transcranial direct current stimulation (tDCS). Adding the method of tDCS to the complex treatment of patients with epilepsy contributes to the improvement of the electroencephalographic pattern, and, accordingly, has a positive effect on the clinical course of the disease. Further research is needed to identify safe and effective therapeutic agents used to treat symptomatic epilepsy.
References
Yatsenko, K.V. (2017). Vplyv kompleksnoi terapii z vykorystanniam mikropoliaryzatsii na elektroentsefalohrafichni pokaznyky u ditei, khvorykh na symptomatychnu epilepsiiu [Influence of complex treatment using transcranial direct current stimulation on the electroencephalographic parameters in children with symptomatic epilepsy]. Ukrainskyi nevrolohichnyi zhurnal – Ukranian Neurology Journal, 3, 21-25 [in Ukranian].
Fisher, R.S., Acevedo, C., Arzimanoglou, A., Bogacz, A., Cross, J.H., Elger, C.E., Engel, J.Jr. et al. (2014). A practical clinical definition of epilepsy. Epilepsia, 55, (4), 475-482.
Abou-Khalil, B., & Misulis, K.E. (2006) Atlas of EEG & seizure semiology. Elsevier.
Abraham, S., & Shaju, M. (2013). Innovations in epilepsy management – an overview. J. Pharm. Pharm. Sci., 16, (4), 564-576.
Duncan, J.S., Sander, J.W., Sisodiya, S.M., & Walker, M.C. (2006). Adult epilepsy. Lancet, 367, (9516), 1087-1100.
Akimova, I.M., & Novikova, T.A. (1978). Ultrastructural changes in the cerebral cortex after transcranial micropolarization. Bull. Exp. Biol. Med., 86, (6), 1669-1672.
Alexopoulos, A.V. (2013). Pharmacoresistant epilepsy: Definition and explanation. Epileptology, 1, (1), 38-42.
Rivera-Urbina, G.N., Nitsche, M.A., Vicario, C.M., & Molero-Chamizo, A. (2017). Applications of transcranial direct current stimulation in children and pediatrics. Rev. Neurosci., 28, (2), 173-184.
Berg, A.T., & Scheffer, I.E. (2011). New concepts in classification of the epilepsies: entering 21st century. Epilepsia, 52, (6), 1058-1062.
Chang, W.P., Lu, H.C., & Shyu B.C. (2015). Treatment with direct-current stimulation against cingulate seizure-like activity induced by 4-aminopyridine and bicuculline in an in vitro mouse model. Exp. Neurol., 265, 180-192.
Sueri, C., Gasparini, S., Balestrini, S., Labate, A., Gambardella, A., Russo, E., Leo, A. et al. (2018). Diagnostic biomarkers of epilepsy. Curr. Pharm. Biotechnol., 19, (6), 440-450.
Engel, J.Jr., McDermott, M.P., Wiebe, S., Langfitt, J.T., Stern, J.M., Dewar, S., Sperling, M.R. et al. (2012). Early surgical therapy for drug-resistant temporal lobe epilepsy: A randomized trial. JAMA, 307, (9), 922-930.
Fisher, R.S., van Emde Boas., W., Blume, W., Elger, C., Genton, P., Lee, P., & Engel, J.Jr. (2005). Epileptic seizures and epilepsy: Definition proposed by the International League Against Epilepsy (ILAE) and the International Bureau for Epilepsy (IBE). Epilepsia, 46, (4), 470-472.
Foldvary–Schaefer, N., & Wyllie, E. (2007). Textbook of clinical neurology (third edition). Elsevier Inc., 1213-1244.
Sinha, S,. Pramod, M.N., Dilipkumar, S., & Satishchandra, P. (2013). Idiopathic generalized epilepsy: Phenotypic and electroencephalographic observations in a large cohort from South India. Аnn. Indian Acad. Neurol., 16, (2), 163-168.
Das, S., Holland, P., Frens, M.A., & Donchin, O. (2016). Impact of transcranial direct current stimulation (TDCS) on neuronal functions. Front Neurosci., 10, 550.
Campos, G., Fortuna, A., Falcão, A., & Alves, G. (2018). In vitro and in vivo experimental models employed in the discovery and development of antiepileptic drugs for pharmacoresistant epilepsy. Epilepsy Res., 146, 63-86.
Johansson, B.B. (2004). Brain plasticity in health and disease. Keio J. Med., 53, (4), 231-246.
Koepp, M. (2012). Neuroimaging: how far could it take us? Go for zero: International Epilepsy Summit, 25-26 May, 2012: аbstracts. Madrid.
Mansvelder, H.D., Verhoog, M.B., & Goriounova, N.A. (2018). Synaptic plasticity in human cortical circuits: cellular mechanisms of learning and memory in the human brain? Curr. Opin. Neurobiol. pii: S0959-4388(18)30069-2.
Miller, J.W., & Henry, J.C. (2013). Solving the dilemma of EEG misinterpretation. Neurology, 80, (1), 13-14.
Medeiros, L.F., de Souza, I.C., Vidor, L.P., de Souza, A., Deitos, A., Volz, M.S., Fregni, F. et al. (2012). Neurobiological effects of transcranial direct current stimulation: a review. Front Psychiatry, 28, (3), 110.
NICE Guideline CG 137 (2012). The Epilepsies: Diagnosis and Management.
Novarino, G., Baek, S.T., & Gleeson, J.G. (2013). The sacred disease: the puzzling genetics of epileptic disorders. Neuron, 80, (1), 9-11.
Perucca, E., Covanis, A., & Dua, T. (2014). Commentary: Epilepsy is a global problem. Epilepsia, 55, (9), 1326-1328.
Perucca, E. (2013). Optimizing antiepileptic drug treatment in tumoral epilepsy. Epilepsia, 54, (9), 97-104.
Perucca, P., & Gilliam, F.G. (2012). Adverse effects of antiepileptic drugs. Lancet. Neurology, 11, (9), 792-802.
Kanner, A.M., Ashman, E., Gloss, D., Harden, C., Bourgeois, B., Bautista, J.F., Abou-Khalil, B. et al. (2018). Practice guideline update summary: Efficacy and tolerability of the new antiepileptic drugs I: Treatment of new-onset epilepsy: Report of the American Epilepsy Society and the Guideline Development, Dissemination, and Implementation Subcommittee of the American Academy of Neurology. Epilepsy Curr., 18, (4), 260-268.
Shorvon, S.D. (2011). The etiologic classification of epilepsy. Epilepsia, 52, (6), 1052-1057.
Sirven, J.I. (2015). Epilepsy: A Spectrum disorder. Cold Spring Harb Perspect Med., 5, (9), a022848.
Sumner, M.G., & Hwang, P.A. (2013). Neuroplasticity, epilepsy and neuroplasticity as a potential treatment for some forms of epilepsy. Clinical Neurophysiology, 124, (6), e3.
Moliadze, V., Andreas, S., Lyzhko, E., Schmanke, T., Gurashvili, T., Freitag, C.M., & Siniatchkin, M. (2015). Ten minutes of 1 mA transcranial direct current stimulation was well tolerated by children and adolescents: Self-reports and resting state EEG analysis. Brain Res. Bull., 119, (Pt A), 25-33.
(2012). The epilepsies: The diagnosis and management of the epilepsies in adults and children in primary and secondary care. Pharmacological Update of Clinical Guideline, 20, 21-28.
Hameed, M.Q., Dhamne, S.C., Gersner, R., Kaye, H.L., Oberman, L.M., Pascual-Leone, A., & Rotenberg, A. (2017). Transcranial magnetic and direct current stimulation in children. Curr. Neurol. Neurosci. Rep. 17, (2), 11-26.
Williams, T.J., & Cervenka, M.C. (2017). The role for ketogenic diets in epilepsy and status epilepticus in adults. Clinical Neurophysiology Practice, 2, 154-160.
Wolf, P. (2014). History of epilepsy: nosological concepts and classification. Epileptic Disord., 16, (3), 261-269.
