STUDY OF THE CONTENT OF ACTIVE METABOLITES OF NITROGEN (II) OXIDE (NO) IN THE BLOOD WITH CHRONIC GASTRITIS IN SMOKERS OF THE MALE FLOOR THAT ARE LONG-TERM IN THE SWEETLY PSYCHO
DOI:
https://doi.org/10.11603/2415-8798.2019.1.9974Keywords:
tobacco smoking, chronic gastritis, nitric oxide, endothelial dysfunctionAbstract
On the territory of our state there are 183 penitentiary institutions and remand prisons, which contain 56638 people. Being in an unfavorable psycho-emotional environment in conditions of prolonged isolation contributes to the abuse of tobacco by men. Smoking causes numerous diseases in the smoker and his environment, depletion of adaptation mechanisms, damage to the endothelium, increase the acidity of gastric juice and the like.
The aim of the study – to determine the concentration of active metabolites of nitric oxide as a marker of endothelial dysfunction in men held in the centers of State Criminal Investigation Service, with chronic gastritis during prolonged smoking.
Materials and Methods. A survey was conducted of convicted men with a smoking history of more than 5 pack-years and an index of smoking severity of more than 4 points. The group 1 (control) included men without concomitant somatic pathology and bad habits. The group 2 – smokers without pathology of the gastrointestinal tract. The group 3 consisted of smokers with chronic gastritis.
Results and Discussion. Smokers with experience had a decrease in the concentration of active metabolites of nitric oxide in the blood compared with the control group. Smokers with chronic gastritis show a further decrease in the concentration of nitric oxide, which may indicate a progression of endothelial dysfunction.
Conclusions. Long-term tobacco smoking in chronic gastritis leads to a decrease in the concentration of active metabolites of nitric oxide in the blood and contributes to the development of endothelial dysfunction.
References
Arkhipova, H.I., & Makarenko, Yu.S. (2012).Vplyv tiutiunokurinnia na orhanizm liudyny [The Influence of Tobacco Smoking on the Human Body]. Visnyk NAU – Bulletin of the NAU, 3, 140-142 [in Ukrainian].
Avramenko, A.O. (2017). Osoblyvosti patohenezu khronichnoho neatrofichnoho hastrytu u spivrobitnykiv Ministerstva vnutrishnikh sprav Ukrainy [Peculiarities of the pathogenesis of chronic non-atrophic gastritis among employees of the Ministry of Internal Affairs of Ukraine]. Bukovynskyi medychnyi visnyk – Bukovinsky medical bulletin, 21, 1 (81), 3-6 [in Ukrainian].
Vyshivanyuk, V.A. (2012). Profilaktika narusheniy mikrotsirkulyatsii v tkanyakh parodonta u kuryashchikh s endotelialnoy disfunktsiyey [Prevention of microcirculation disorders in periodontal tissues in smokers with endothelial dysfunction]. Moscow, p. 23 [in Russian].
Golikov, P.P., & Nikolayeva, Yu. (2004). Metod opredeleniya nitrita/nitrata (NOX) v cyvorotke krovi [Method for determination of nitrite / nitrate (NOX) in serum]. Biomeditsinskaya khimiya – Biomedical chemistry, 50, 1, 79-85 [in Russian].
Derzhavna kryminalno-vykonavcha sluzhba Ukrainy [The State Criminal Execution Service of Ukraine]. Retrieved from: http://www.kvs.gov.ua
Tkach, S.M. (2012). Vliyaniye alkogolya i kureniya na organy pishchevareniya [The effect of alcohol and smoking on the digestive organs]. Zdorovia Ukrainy – Health Ukraine, 38-39 [in Russian].
Todoriko, L.D. (2010). Patohenetychna kharakterystyka prohresuvannia systemnoho zapalennia pry khronichnykh obstruktyvnykh zakhvoriuvanniakh lehen u litnomu i starechomu vitsi [Pathogenetic characteristic of the progression of systemic inflammation in chronic obstructive pulmonary diseases in the elderly and the elderly]. Ukrainskyi terapevtychnyi zhurnal – Ukrainian Therapeutic Journal, 2, 107-112 [in Ukrainian].
Ukrainska asotsiatsiia profilaktychnoi medytsyny [Ukrainian Association of Preventive Medicine]. Retrieved from: http://uapm.org.ua.
Richmond, R., Indig, D., Butler, T., Wilhelm, K., Archer, V., & Wodak, A. (2012). A randomized controlled trial of a smorking cessation intervention conducted among. Addiction, 966-974.
Li, L.F., Chan, R.L., Lu, L., Shen, J., Zhang, L., Wu, W.K., … & Cho, C.H. (2014). Cigarette smoking and gastrointestinal diseases: The causal relationship and underlying molecular mechanisms (Review). International Journal of Molecular Medicine, 34, 372-380.
Shin, V.Y., Liu, E.S., Koo, M.W., Wang, J.Y., Matsui, H., & Cho, C.H. (2002). Cigarette smoke extracts delay wound healing in the stomach: involvement of polyamine synthesis. Exp Biol Med., 227, 114-124.
Ali, S.S., Hamed, E.A., Ayuob, N.N., Shaker, A.A., & Suliman, M.I. (2015). Effects of different routes of nicotine administration on gastric morphology and hormonal secretion in rats. Exp Physiol, 100 (8), 881-895.
Mishra, A., Chaturvedi, P., Datta, S., Sinukumar, S. Joshi, P., & Garg, A. (2015). Harmful effects of nicotine. Indian J Med Paediatr Oncol, 36, 24-31.
Dempsey, D., Tutka, P., Jacob, P.3rd, Allen, F., Schoedel, K., Tyndale, R.F., & Benowitz, N.L. (2004). Nicotine metabolite ratio as an index of cytochrome P450 2A6 metabolic activity. Clin Pharmacol Ther, 76, 64-72.
Ma, L., Wang, W. P., Chow, J.Y., Yuen, S.T., & Cho, C.H. (2000). Reduction of EGF is associated with the delay of acetic acid induced gastric ulcer healing by cigarette smoking. Physiol Gastrointest Liver Physiol, 278, 10-17.
Sobkowiak, R., & Lesicki, A. (2013). Absorption, metabolism and excretion of nicotine in humans. Postepy Biochem, 59, 33-44.
WHO urges more countries to require large, graphic health warnings on tobacco packaging: the WHO report on the global tobacco epidemic, 2011 examines anti-tobacco mass-media campaigns. Cent Eur J Public Health, 19, 1331512011.
Downloads
Published
How to Cite
Issue
Section
License
Authors who sent their manuscript to "Вісник наукових досліджень. Bulletin of Scientific Research" Surgery agree to the following terms:
a. Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal. 
b. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
c. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access)
