SOME PREDICTORS OF THE EXPRESSION OF PSYCHOPATHOLOGICAL SYMPTOMATICS IN PARANOID SCHIZOPHRENIA
DOI:
https://doi.org/10.11603/2415-8798.2019.1.9938Keywords:
paranoid schizophrenia, autonomic nervous systemAbstract
This article analyzes peculiarities of psychopathological symptoms of paranoid schizophrenia considering the functional state of the autonomic nervous system.
The aim of the study – to explore the peculiarities of psychopathological symptoms in patients with paranoid schizophrenia, considering the functional state of the autonomic nervous system.
Materials and Methods. Clinical and psychopathological examination of 144 men with paranoid schizophrenia, using PANSS scale, questionnaire A.M. Wein and study of cardiac rhythm variability was conducted.
Results and Discussion. It was established that patients with paranoid schizophrenia have symptoms of relative sympathicotonia (45.1 %) and parasympathicotonia (41.7 %) with significantly lower expression of eutonia (13.2 %). It was established that patients with sympathicotonia symptoms are generally more expressive of psychopathological symptoms (115.03±11.71) points in comparison with patients with signs of parasympathicotonia (99.08±11.13) points and eutonia (89.74±15.00) points (p<0.01). This tendency is most pronounced for productive symptoms (30.62±2.94) points, (21.60±3.64) points, and (21.63±2.61) points, p<0.01) and general symptoms (respectively, (56.86±6.17) points, (45.58±7.18) points and (51.27±6.03) points, p<0.01), and the least for negative symptoms (27.55±6.27) points, (22.53±8.02) points and (26.22±6.28) points, and also appears in the analysis of individual symptoms that are part of the positive, negative and general cluster of psychopathological symptoms of schizophrenia. In patients with symptoms of sympathicotonia, the severity of thinking abnormalities (13.02±3.03) points, (8.83±2.10) points and (8.47±1.93) points, p<0.01), excitation (10.91±1.84) points, (8.83±1.88) points and (8.68±1.60) points, p<0.01) and paranoid behavior (13.78±1.87) points, (10.12±2.87) points and (9.68±2.45) points, p<0.01. At the same time, differences in the severity of psychopathological symptoms among patients with parasympathicotonia and eutonia are lower than among patients with sympathicotonia and patients of other groups. At the same time, the regularities regarding the relationships between different psychopathological symptoms and the functional state of autonomic nervous system in paranoid schizophrenia are complex and ambiguous. The existence of significant correlations between the LF/HF index of heart rate variability and the indicators of the expressiveness of productive psychopathological symptoms (rS=-0.749), paranoid behavior (rS=-0.706), mental disorders (rS=-0.698), excitation (rS=-0.644), overall severity of psychopathological symptoms (rS=-0.614), general symptoms of schizophrenia (rS=-0.440), and severity of negative symptoms (rS=-0.145).
Conclusions. The revealed patterns show the link between the expressiveness of the psychopathological symptoms of paranoid schizophrenia and the indicators of the functional state of the autonomic nervous system.
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