ANTIBODIES TO THYROID STIMULATING HORMONE RECEPTORS, THYROPEROXIDASES AND HORMONAL THYROID GLAND FUNCTION IN PATIENTS WITH THYROTOXICOSIS
DOI:
https://doi.org/10.11603/2415-8798.2018.4.9798Keywords:
thyroid-stimulating hormone receptor antibodies, thyroperoxydase antibodiesAbstract
The article presents the results of examination of patients with diffuse toxic goiter, nodular toxic goiter and autoimmune thyroiditis. The thyroid stimulating hormone, antibodies to thyroid hormone receptors and thyroperoxidase in patients with various clinical and pathogenetic forms of thyrotoxicosis were studied. The conducted studies allowed to evaluate the hormonal function of the gland in patients with various clinical and pathogenetic forms of thyrotoxicosis.
The aim of the study – to learn the indicators of thyrotropic hormone, antibodies to receptors of thyroid stimulating hormone and to thyroperoxidase in patients with various clinical and pathogenetic forms of thyrotoxicosis.
Materials and Methods. We examined 94 patients with thyrotoxicosis aged from 19 to 61 years. There were 14 men and 80 women. The examination was carried out at the initial treatment of patients for treatment in a certified laboratory "Sіnevo". Statistical surveys were carried out under the computer program "Statistics".
Results and Discussion. The conducted studies allowed evaluating the hormonal function of the gland in patients with various clinical and pathogenetic forms of thyrotoxicosis. We found that the level of thyroid hormone in all patients with thyrotoxicosis is low and its level does not depend on its clinical and pathogenetic form. In determining the severity of thyrotoxicosis, the level of thyroxine is approximately in the blood. With the increase in its content the severity of thyrotoxicosis increases, which is confirmed by data from patients with diffuse toxic goiter and nodular toxic goiter.
Conclusions. For patients with thyrotoxicosis, a characteristic laboratory diagnostic is the low level of thyroid hormone, regardless of the clinical-pathogenetic form of thyrotoxicosis. The level of thyroid hormone receptor antibodies is a pathogenetic sign of diffuse toxic goiter. With the increase in their blood levels, the severity of thyrotoxicosis increases, regardless of the duration of the disease and the age of the patients. The level of antibodies to thyroperoxydase characterizes the activity of the autoimmune process in the thyroid gland. Their highest level was determined in patients with autoimmune (destructive) thyroiditis and the smallest it was in patients with nodular toxic goiter.
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