STATUS OF FAGOCYTOSIS IN EXPERIMENTAL ANIMALS IN ADRENALINE MYOCARDIOPATHY

Abstract

Taking into account the high prevalence of cardiovascular diseases in the world, earlier studies of the peculiarities of the metabolism and structure of the myocardium when damaged by its adrenaline insufficiently reveal the state of immune responses, in particular the role of phagocytes in the development of adrenergic myocardial damage when the body reactivity changes.

The aim of the study – to learn the state of phagocytosis in the development of adrenal myocardial infection in animals with different types of inflammatory response.

Materials and Methods. Experiments were conducted on 60 non-linear male rats weighing 180–200 g, divided into three groups: group 2 – 18 white rats with adrenal myocardial infarction; group 2 – 18 white rats, in which adrenal myocardial infarction was induced in the background of hypoergic inflammatory reaction; the group 3 – 18 white rats, in which adrenal myocardial infarction was caused by a hyperergic inflammatory reaction. Phagocytic activity of leukocytes was determined by two indicators: the percentage of phagocytic leukocytes and phagocytic number.

Results and Discussion. For the normal course of an inflammatory reaction, the phagocyte count decreased significantly only for 24 hours of development of adrenal myocardial infarction with a 7-day recovery. During the hyperergic course of the inflammatory reaction, the depression of the activity of phagocytes, which arose already for 1 year of development of adrenal myocardial infarction, decreased somewhat for 24 hours, and at 7 days the activity of leukocytes was restored.

Conclusions. For all types of inflammatory response of the body, the phagocytic activity of leukocytes is suppressed in the development of adrenal myocardial infarction, as evidenced by a decrease in phagocytic number. The intensity of such changes is most significant in the hypoergic course of the inflammatory reaction. By the indicator of the percentage of phagocytic leukocytes there was a decrease from the index of intact animals in all terms of observation.