GENDER DIFFERENCES OF COMPLETE BLOOD COUNT AND LIPID PROFILE IN ACUTE CORONARY SYNDROME WITHOUT ST SEGMENT ELEVATION IN PATIENTS WITH ESSENTIAL ARTERIAL HYPERTENSION AND HELICOBACTER PYLORI INFECTION

Abstract

Acute coronary syndrome (ACS) is an important cause of disability and death of patients, despite significant advances in diagnosis and treatment where ACS without ST elevation segment is observed more often and characterized by twice higher death rate in the long run that ACS with ST elevation syndrome. Essential arterial hypertension, dyslipidemia and systemic inflammation are important risk factors of ACS development.

The aim of the study – to investigate the gender differences of complete blood count and lipid profile features acute coronary syndrome without ST segment elevation patients with essential hypertension and Helicobacter pylori infection.

Materials and Methods. 134 acute coronary syndrome patients (age 45–83 years) with primary arterial hypertension and dyspeptic complaints were investigated in accordance to the current protocols of acute coronary syndrome without ST segment elevation, essential arterial hypertension and dyspepsia management. The patients were divided by the groups of men and women, infected und uninfected with Helicobacter pylori. The control group included 30 healthy persons of the same age and gender.

Results and Discussion. In case of Helicobacter pylori infection the significantly higher hepatomegaly and platelets/lymphocytes ratio were observed in men versus women while in the groups of the patients uninfected with Helicobacter pylori we didn’t reveal any significant gender differences of those indices. The ESR, levels of total cholesterol, low density lipoproteins and the atherogenic index of plasma were significantly higher in patients infected with Helicobacter pylori versus uninfected, regardless of gender. In men infected versus uninfected with Helicobacter pylori the significantly higher hepatomegaly, lower ejection fraction, high ESR and platelets/lymphocytes ratio were revealed that wasn’t observed among women.

Conclusions. The obtained data might indicate the significant progression of heart failure, dyslipidemia and systemic inflammation in men infected with Helicobacter pylori versus uninfected and in men versus women regardless of Helicobacter pylori infection factor.