GENDER FEATURES OF THE COMBINATION OF STABLE ISCHEMIC HEART DISEASE AND CHRONIC OBSTRUCTIVE PULMONARY DISEASE

Abstract

Studies show the dynamics of gender characteristics of ischemic heart disease in recent years. In the case of combination with chronic obstructive pulmonary disease, the clinical course of the pathologies may vary, which needs to be evaluated depending on the gender of the patients.

The aim of the study – to determine the clinical and functional characteristics of the course of combination of stable ischemic heart disease and chronic obstructive pulmonary disease according to the gender of patients.

Materials and Methods. 98 patients with a combination of stable ischemic heart disease and chronic obstructive pulmonary disease, including 78 men and 20 women, were examined. The data of general clinical examination, severity of shortness of breath for modified Medical Research Council (mMRC) and COPD assesstment test (CAT), ECG, spirography, daily ECG monitoring, echocardiography, quality of life parameters according to the MOS SF 36 questionnaire were evaluated.

Results and Discussion. Differences in the clinical forms of ischemic heart disease, the degree of damage of coronary arteries and the groups of chronic obstructive pulmonary disease have not been established. Indicators of the function of external respiration did not differ between men and women, but women were characterized by more severe dyspnea according to the questionnaire of mMRC (p = 0.007) and CAT (p = 0.009).

The overall indicator of the physical status of quality of life in women is lower than in men – (25.8±2.8) against (38.1±2.3), respectively (p = 0.005). The tendency to a greater number of ventricular extrasystoles in men is determined – 428 (91; 1361) per day, whereas in women 247 (7; 496) are determined per day. All patients have signs of remodeling of the left and right chambers of the heart, but no gender difference is established.

Conclusions. Women with a combination of stable ischemic heart disease and chronic obstructive pulmonary disease have lower quality of life indicators, a greater need for medical care than men, although there is no significant difference in instrumental indicators.