FEATURES OF PREGNANCY IN THE WOMEN OF THE GROUP WITH A HIGH RISK OF LATE GESTOSIS DUE TO METABOLIC SYNDROME (literatyre review)

Authors

  • S. V. Khmil I. Horbachevsky Ternopil State Medical University
  • U. Ya. Franchuk I. Horbachevsky Ternopil State Medical University

DOI:

https://doi.org/10.11603/2415-8798.2017.4.8432

Keywords:

late gestosis, metabolic syndrome, endothelial dysfunction, obesity.

Abstract

Late gestosis is one of the important problems in modern obstetrics. Despite significant advances in the diagnosis, prevention and treatment of preeclampsia, gestosis remains a terrible disease in the second half of pregnancy. At the same time, the number of obstetric complications in pregnant women is also associated with a medical and social problem, such as metabolic syndrome. The study of the role of metabolic syndrome in the pathogenesis of disease development gains increasing importance in all branches of medicine. The main risk factors for the development of metabolic syndrome are: dyslipidemia, obesity, arterial hypertension and hyperglycemia onset. Their occurrence is associated with the influence of the following stress factors: tobacco smoking, unbalanced diet, sedentary lifestyle, and others. However, a significant cohort of scientists supports the hypothesis that the perinatal stage is determined by the risk of metabolic syndrome development.

Author Biography

S. V. Khmil, I. Horbachevsky Ternopil State Medical University

 

References

Ailamazian Ye.K. & Repina М. А. (2012). Komentarii k klinicheskomu protokolu “Gipertenziya vo vremia beremennosti, preeklampsiya, eklampsiya” [Comments on the clinical protocol "Hypertension during pregnancy, pre-eclampsia, eclampsia]. Zhurnal akusherstva i genskih boleznei – Journal of Obstetrics and Womens Diseases, (57)5, 3-9 [in Russian].

Gordyunina, S.V. (2012). Insulinorezistentnost i regulyatsiya metabolizma [Insulin resistance and regulation of metabolism]. Problemy endokrinologii – Problems of endocrinology, 3, 31-34 [in Russian].

Hryshchenko, O.V. (2017). Riven uskladnen vahitnosti, polohiv i puerperiiu u zhinok z preeklampsiieiu [The level of complications of pregnancy, childbirth and puerperium in women with preeclampsia]. Zbirnyk naukovykh prats asotsiatsii akusher-hinekolohiv Ukrayiny – Collection of scientific works of the obstetrician-gynecologists association of Ukraine, 1 (39), 37-41 [in Ukrainian].

Gureyev, V.V. (2012). Endotelialnaya disfunktsiya – tsentralnoye zveno v patogeneze gestoza [Endothelial dysfunction - the central link in the pathogenesis of gestosis]. Nauchnyye vedomosti Seriya Meditsina. Farmatsiya – Scientific Bulletin Series Medicine. Pharmacy, 4 (123), 17 (1), 5-12 [in Russian].

Gromova, A.M., Líkhachov, V.K. & Dobrovolska L.M. (2011). Dinamika izmeneniy krovotoka v matochno-platsentarnom i plodovo-platsentarnom basseynakh pri preeklampsii [Dynamics of changes in blood flow in the utero-placental and fertile-placental basins under preeclampsia]. Svit medytsyny ta biolohii – World of Medicine and Biology, 2, 111-114 [in Russian].

Dindar, O.A. (2015). Gistogenez uskladnen vahitnosti i polohiv u zhinok iz metabolichnym syndromom i ozhyrunniam [Histogenesis of complications of pregnancy and childbirth in women with metabolic syndrome and obesity]. Zdorovye zhenshchiny – Woman’s health, 10 (106), 114-117 [in Ukrainian].

Dubossarskaya, Z.M. & Duka, Yu.M. (2011). Rol ozhereniya v strukture nevynashivaniya beremenosti [The role of burning in the structure of pregnancy absent pregnancy]. Reproduktivnaya endokrinologiya – Reproductive endocrinology, 2, 9-11 [in Russian].

Ivaniuta, S.O., Dindar, O.A., Makarenko, G.I. & Kurochka V.V. (2017). Metabolichnyi syndrom – pandemiia XXI stolittia, nagalna problema akusherstva [Metabolic syndrome - a pandemic of the twenty-first century, an urgent problem of obstetrics]. Zbirnyk naukovykh prats asotsiatsii akusher-hinekolohiv Ukrainy – Collection of scientific works of the obstetrician-gynecologists association of Ukraine, 2 (40), 134-138 [in Ukrainian].

Savelyeva, G.M. (2013). Kakoy klassifikatsii gestozov (preeklampsii) dolzhen priderzhivatsya vrach v povsednevnoy rabote? [What classification of gestosis (pre-eclampsia) should adhere to the doctor in everyday work?]. Zhurnal akusherstva i zhenskikh bolezney – Journal of Obstetrics and Women's Diseases, (57) 1, 5-9 [in Russian].

Kaminskyi, V.V. & Zhuk, C.I. (2015). Shliakhy znyzhennia materynskoi smertnosti: ukrayinski realii i mizhnarodnyi dosvid [Ways to reduce maternal mortality: Ukrainian realities and international experience]. Zhinochyy likar – Woman's doctor, 2, 10-14 [in Ukrainian].

Kaminskyi, V.V. (2013). Problemy materynskoi smertnosti v Ukrayini: ekstrahenitalna patolohiia yak kliuchovyi element dlia znyzhennia materynskoi smertnosti [Maternal mortality problems in Ukraine: extragenital pathology as a key element in reducing maternal mortality]. Materialy III Vseukrayinskoi naukovo-praktychnoi konferentsii «Vnutrishnia patolohiia v akusherstvi ta hinekolohii» – Materials of the third all-Ukrainian Scientific and Practical Conference "Internal Pathology in Obstetrics and Gynecology", Ternopil, 3-5 [in Ukrainian].

Korchynska, O.O., Voloshyna, U.V. & Tsybyk, T.V. (2011). Perebih vahitnosti ta polohiv u zhinok z ozhyrinniam [Pregnancy and childbirth in obese women]. Ukrayina. Zdorovia natsii – Ukraine. The health of the nation, 1, 89-92 [in Ukrainian].

Kutsenko, A.V. (2012). Kliniko-patohenetychni osoblyvosti perebihu vahitnosti ta polohiv i korektsiia uskladnen u zhinok iz metabolichnym syndromom [Clinical and pathogenetic features of the course of pregnancy and childbirth and correction of complications in women with metabolic syndrome]. Extended abstract of candidate’s thesis : Kyiv, 19 p. [in Ukrainian].

Lutsenko, N.S. (2000). Akusherskiye aspekty ozhireniya [Obstetric aspects of obesity]. Zaporozhye : Prosvita, 160 p. [in Russian].

Makarov, I.O., Borovkova, Ye.I. & Bayramova, M.Yu. (2011). Techeniye beremennosti i rodov u patsiyentok s ozhireniyem [The course of pregnancy and childbirth in patients with obesity]. Akusherstvo, ginekologiya i reproduktsiya – Obstetrics, gynecology and reproduction, 1, 22-28 [in Russian].

Pedachenko, N.Yu. (2013). Reproduktyvne zdorovia zhinok z metabolichnym syndromom [Reproductive health of women with metabolic syndrome]. Extended abstract of Doctor’s thesis : K., 33 p. [in Ukrainian].

Pedachenko, N.Yu. (2013). Sotsialno-psikholohichni osoblyvosti zdorovia zhinok iz metabolichnym syndromom [Socio-psychological peculiarities of women's health with metabolic syndrome]. Ukrainskyi medychnyi chasopys – Ukrainian Medical Journal, 95, 146-149 [in Ukrainian].

Shcherbakov, A.Yu., Tikhaya, I.A., Shcherbakov, V.Yu. & Novikova Ye.A. (2012). Platsentarnaia disfunktsiia na fone endokrinnoi patolohii [Placental dysfunction against the background of endocrine pathology]. Mezhdunarodnyy meditsinskiy zhurnal – International Medical Journal, (18), 3, 50-53 [in Russian].

Potapov, V.A. & Davydova, Yu.V. (2014). Kontroliruyemyye riski i strategiya profilaktiki prezhdevremennoy poteri beremennosti [Controlled risks and strategy for the prevention of premature loss of pregnancy.]. Zdorovye zhenshchiny – Women's health, 7 (93), 20-23 [in Russian].

Rasin, M.S. & Zhitnik, V.P. (2015). Sistemnoye vospaleniye i insulinorezistentnost v patogeneze sindroma polikistoznykh yaichnikov [Systemic inflammation and insulin resistance in the pathogenesis of polycystic ovary syndrome]. Akusherstvo i ginekologiya – Obstetrics and Gynecology, 8, 26-32 [in Russian].

Repina, M.A. & Korzo, T.M. (2015). Mesto sistemnoy enzimoterapii v vyzhidatelnom lechenii beremennykh s gestozom [Place of systemic enzyme therapy in expectant treatment of pregnant women with gestosis]. Zhurnal akusherstva i zhenskikh bolezney – Journal of Obstetrics and Women's Diseases, (64) 1, 76-82 [in Russian].

Savelyeva, G.M. (2003). Dostizheniya i perspektivy perinatalnoy meditsiny [Achievements and prospects of perinatal medicine]. Akusherstvo i ginekologiya – Obstetrics and Gynecology, 2, 3-6 [in Russian].

Serhiienko, L.Yu. (2014). Ranniy ontogenez – kriticheskiy period dlya «programmirovaniya» endokrinnykh i gormonalno-zavisimykh patologiy vo vzrosloy zhizni [Early ontogeny is a critical period for the "programming" of endocrine and hormone-dependent pathologies in adulthood]. Klinichna ta eksperimentalna patolohiia – Clinical and Experimental Pathology, (13) 3 (49), 224-230 [in Russian].

Serov, V.N., Frolova, O.G. & Tokova, Z.Z. (2001). Osnovnyye problemy materinskoy smertnosti v posledniye 5 let [The main problems of maternal mortality in the last 5 years]. Problemy beremennosti – Problems of pregnancy, 3, 15-19 [in Russian].

Sidorova, I.S. (2003). Gestoz: ucheb. posobiye [Gestosis: Textbook allowance]. M. : Meditsina [in Russian].

Zhabchenko, I.A., Tsypkun, A.G., Zhitskiy, A.M. & Skripchenko N.Ya. (2011). Sovremennyye podkhody k diagnostike i lecheniyu platsentarnoy disfunktsii [Modern approaches to the diagnosis and treatment of placental dysfunction]. Tavricheskiy mediko-biologicheskiy vestnik – Taurian medical and biological bulletin, (14) 3, ch. 1 (55), 81-88 [in Russian].

Tarasenko, K.V. & Hromova, A.M. (2016). Osoblyvosti metabolichnykh zmin u vahitnykh zhinok z ozhyrinniam III stupenia [Features of metabolic changes in pregnant women with obesity of the III degree]. Eksperymentalna i klinichna medytsyna – Experimental and Clinical Medicine, 2 (71), 207-210 [in Ukrainian].

Tereshchenko, I. V. & Panova, L.Yu. (2009). Techeniye beremennosti i rodov pri ozhirenii razlichnogo geneza The course of pregnancy and childbirth with obesity of different genesis]. Akusherstvo i ginekologiya – Obstetrics and Gynecology, 1, 23-25 [in Russian].

Shelestova, L.P. (2012). Vahitnist i polohy u zhinok z alimentarno-konstytutsialnym ozhyrinniam (patohenez, profilaktyka ta likuvannia akusherskykh i perynatalnykh uskladnen) [Pregnancy and childbirth in women with alimentary-constitutional obesity (pathogenesis, prevention and treatment of obstetric and perinatal complications)]. Extended abstract of Doctor’s thesis. Kyiv : Nats. med. akad. pislyadyplomnoi osvity im. P.L. Shupyka, 40 p. [in Ukrainian].

Kaminskyi, V.V., Ventskivskyi, B.M. & Bila, V.V. (2012). Shliakhy podolannia problemy nevynoshuvannia vahitnosti i peredchasnykh polohiv v Ukrayini [Ways of overcoming the problem of non-pregnancy and premature birth in Ukraine]. Zhinochyy likar – Woman's doctor, 6, 9-11 [in Ukrainian].

Mozgovaya, Ye.V., Malysheva, O.V. & Ivashchenko, T.E. (2003). Endotelialnaya disfunktsiya pri gestoze. Patogenez, geneticheskaya predraspolozhennost, diagnostika i profilaktika: metod. rekomendatsii [Endothelial dysfunction with gestosis. Pathogenesis, genetic predisposition, diagnosis and prevention: a method. recommendations]. SPb. [in Russian].

Behjat, S.S. (2017). The Effects of Vitamin D Supplement on Prevention of Recurrence of Preeclampsia in Pregnant Women with a History of Preeclampsia. Obstet Gynecol Int. 2017;8249264. doi: 10.1155/2017/8249264. Epub Aug 17.

Block, H.S. (2016). Neurological complications of pregnancy. Curr Neurol Neurosci Rep., (16) 7, 67.

Brannian, J.D. & Med, S.D. (2011). Obesity and fertility, 64 (7), 251-254.

Dennis, A.T. (2012). Management of pre-eclampsia: issues for anaesthetists. Anaesthesia, (67), 9, 1009-1020.

Imarengiaye, C.O. & Isesele, T.O. (2015). Intensive care management and outcome of women with hypertensive diseases of pregnancy. Niger Med J., (56) 5, 333-337.

Mladenova, M., Dimitrakova, E., Amaliev, G. & Pehlivanov B. (2011). Insulin resistance in preeclampsia. Akush. Ginekol. (Sofiia), 50 (7), 31-33.

Javorski, N.R. (2017). Vitamin D receptor (VDR) polymorphisms are associated to spontaneous preterm birth and maternal aspects. Gene. pii: S0378-1119(17)30933-2. doi: 10.1016/j.gene.2017.10.087.

Ji, J.L. (2017). Immunological function of vitamin D during human pregnancy. Am J Reprod Immunol, 78 (2). doi: 10.1111/aji.12716. Epub 2017 Jun 6.

Mingot, D.L. (2017). Epigenetic effects of the pregnancy Mediterranean diet adherence on the offspring metabolic syndrome markers. J Physiol Biochem., 73 (4), 495-510. doi: 10.1007/s13105-017-0592-y. Epub 2017 Sep 18.

Hauth, J.C., Clifton, R.G. & Roberts J.M. (2011). Maternal insulin resistance and preeclampsia. Am. J. Obstet. Gynecol, (204), 327, E1-E6.

Mathias, P.C., Elmhiri, G. & de Oliveira, J.C. (2014). Maternal diet, bioactive molecules, and exercising as reprogramming tools of metabolic programming. Eur. J. Nutr, 53 (3), 711-722.

Norman, J.E. & Reynolds, R.M. (2011). The consequences of obesity and excess weight gain in pregnancy. Proc. Nutr. Soc., 70 (4), 450-456.

Mc Knight, J.R., Satterfield, M.C. & Li, X. (2011). Obesity in pregnancy: problems and potential solutions. Front Biosci (Elite Ed), 3, 442-452.

Muhlhausler, B.S., Gugusheff, J.R., Ong, Z. Y. & Vithayathil, M.A. (2013). Pregnancy, obesity and insulin resistance: maternal overnutrition and the target windows of fetal development. Horm. Mol. Biol. Clin. Investig, 15 (1), 25-36.

Turgut, A., Ozler, A. & Goruk N.Y. (2015). Serum levels of the adipokines, free fatty acids, and oxidative stress markers in obese and non-obese preeclamptic patients. Clin. Exp. Obstet. Gynecol, 42 (4), 473-479.

Thompson, J.A. & Regnault T.R. (2011). In utero origins of adult insulin resistance and vascular dysfunction. Semin. Reprod. Med, 29 (3), 211-224.

Yajnik, C.S. (2014). Transmission of obesity-adiposity and related disorders from the mother to the baby. Ann. Nutr. Metab, 64, suppl 1, 8-17.

Yu, R.Q. (2017). Relationship between serum 25(OH)D levels at birth and respiratory distress syndrome in preterm infants. Zhongguo Dang Dai Er Ke Za Zhi, 19 (11), 1134-1137.

Published

2018-01-13

How to Cite

Khmil, S. V., & Franchuk, U. Y. (2018). FEATURES OF PREGNANCY IN THE WOMEN OF THE GROUP WITH A HIGH RISK OF LATE GESTOSIS DUE TO METABOLIC SYNDROME (literatyre review). Bulletin of Scientific Research, (4). https://doi.org/10.11603/2415-8798.2017.4.8432

Issue

Section

REVIEWS AND ORIGINAL RESEARCH