MORPHOLOGICAL FEATURES OF POSTOPERATIVE SCARS OF SKIN IN THE APPLICATION OF COMBINED PREVENTION (EXPERIMENTAL STUDY)
DOI:
https://doi.org/10.11603/2415-8798.2017.4.8405Keywords:
extracorporal shock-wave therapy, pathological postoperative scars, elastic fibers, collagen fibers.Abstract
The problem of pathological postoperative cicatrization of skin remains relevant and insufficiently studied. Scar is a product of skin regeneration by connective tissue structures after its damage or inflammatory process for supporting integrity of body's covers.
The aim of the study – to learn the effect of extracorporeal shock-wave therapy (ESWT ) and Strataderm silicone gel on the morphological features of reparative regeneration of scar tissue of the skin in experimental animals.
Materials and Methods. Experimental study was performed on 16 male rabbits divided into four groups and learnt in them the effect of complex prophylaxis of pathological post-operative skin scars formation.
Results and Discussion. The skin glands were arranged in one row superficially and hair follicles were completely absent. The scar was formed by coarse disordered collagen fibers. Collagen fibers were thin and there was a very small amount of thin muscle fibers between them. Cutaneous appendages were better developed: the glands were arranged in one row superficially being larger than in the control group. Sebaceous glands were grouped in two or three rows. Hair follicles regenerated and they were arranged in several rows. The scar was formed by disordered collagen fibers. A multirowed stratum corneum was revealed in the morphological study of animals of experimental group number. Completely restored appendages of the skin were observed: sebaceous glands and hair follicles regenerated and formed groups arranged in several rows. The scar was formed by coarse ordered collagen fibers.
Conclusions. Experimental study proves the effectiveness of the combined prevention of pathological postoperative cicatrization. Extracorporeal shock-wave therapy was established to affect the regeneration of elastic and collagen fibers and smooth muscle cells of the dermis positively. In its turn, the use of a silicone gel contributes to the formation of multinucleated epidermis and the complete restoration of the architectonics of cutaneous appendages. Combined use of ESWT and Strataderm silicone gel integrates the merits of both methods and promotes the formation of normotrophic scar, which involves the balance of such processes as the formation of the epidermis and the regeneration of collagen and elastic fibers along with appendages of the skin.
References
Avetikov, D.S., Loza, K.O. (2014). Analysis of the effectiveness of modern methods of preventing the formation of pathological scars. The European scientificand practical congress «Global scientificunity 2014». Prague, (2), 46-49. [in Ukrainian].
Kulikovskii, V.F., Oleynik, I.V., Dolzhikov, A.A. & Shcherbatova, Y.E. (2007). Experimental rationale fo early correction scars CO2 laser radiation. Almanac of Clinical Medicine, (16), 93-99. [in Russian].
Gafarov, T.U., Enikeev, D.A., Idrisov, L.T., Yenikeyeva, S.A. & Klimov, D.M. (2013). Modeling atrophic scar skin blemishes in laboratory animals. Successes contemporary science, (6), 89-91 [in Russian].
Ostrovsky, O.A. (2013). Changes in cells and tissues of living organisms under the influence of shock wave therapy (review of special literature). Sports Medicine, (1), 7-11 [in Ukrainian].
Shel, Ya. (2013). Modern concept of focused and radial therapy. Sports medicine, (1), 3-6 [in Russian].
Hartwell, R., Poormasjedi-Meibod, M.S. & Chavez-Munoz, C. (2015). An in-situ forming skin substitute improves healing outcome in a hypertrophic scar model. Tissue. Eng. Part A, 21 (5-6), 1085-1094.
Hoeksema, H., De Vos, M., Verbelen, J., Pirayesh, A. & Monstrey, S. (2013). Scar management by means of occlusion and hydration: a comparative study of silicones versus a hydrating gel-cream Burns., 39 (7), 1437-1448.
Kisch, T., Sorg, H., Forstmeier, V., Knobloch, K., Liodaki, E., Stang, F. … Krämer, R. (2015). Remote effects of extracorporeal shock wave therapy on cutaneous microcirculation J. Tissue Viability, 24 (4), 140-145.
Palmieri, A. (2009). A first prospective, randomized, double-blind, placebo-controlled clinical trial evaluating extracorporeal shock wave therapy (ESWT) for the treatment of peyronie’s disease (PD). Europ. Urol., 56 (2), 363-370.
Tark, K.C., Lee, D.W. & Lew, D.H. (2015). Effects of ginsenoside Rb1 on hypertrophic scar remodeling in rabbit model. Eur. J. Pharmacol, 750 (5): 151-159.
Wang, Y.W., Liou, N.H. & Cherng, J.H. (2014). siRNA-targeting transforming growth factor-β type I receptor reduces wound scarring and extracellular matrix deposition of scar tissue. J. Invest. Dermatol, 134 (7): 2016-2025.
Willital, G.H. & Simon, J. (2013). Efficacy of early initiation of a gel containing extractum cepae, heparin, and allantoin for scar treatment: an observational, noninterventional study of daily practice. J. Drugs Dermatol., 12 (1): 38-42.
Wu, C., Jiang, J. & Boye, A. (2014). Compound Astragalus and Salvia miltiorrhiza extract suppresses rabbits hypertrophic scar by modulating the TGF-β. Dermatology, 229 (4), 363-368.
Downloads
Published
How to Cite
Issue
Section
License
Authors who sent their manuscript to "Вісник наукових досліджень. Bulletin of Scientific Research" Surgery agree to the following terms:
a. Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal. 
b. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
c. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access)
