CLINICAL EFFECTIVENESS OF PHYTOPREPARATUM "RESVERAZIN" IN THE COMPLEX TREATMENT OF GENERALIZED PARODONTITIS
DOI:
https://doi.org/10.11603/2415-8798.2017.4.8321Keywords:
generalized periodontitis, general treatment, resveratrol, Resverazin.Abstract
Periodontal disease is one of the most common lesions of the human body today. According to WHO (1990), from 55 to 98 % of the adult population of the planet has a pathology of periodontal disease, the highest incidence rate was recorded in individuals 15–19 year-old (55–89 %) and 35–44 years (65–98 %) [1, 3, 6]. High prevalence, unfavorable effects of periodontal infection centers on the oral cavity and organism in general, high level of complications associated with functional and morphological disorders due to loss of teeth – all this determines the relevance of this problem.
The aim of the study – to evaluate the clinical efficacy of the drug "Resverazin" in the complex treatment of generalized periodontitis.
Materials and Methods. The study involved 43 patients with chronic generalized periodontal disease. The assessment of the periodontal condition was conducted according to clinical signs. To assess the hygienic state of the cavity, the indices Green-Wermillion, ON I-S, Silness-Loe were used. Stallard, periodontal indexes: PMA, PI, Bush index by Muhlleman. Definition and counting of indices was carried out according to generally accepted methods. Patients in the main group in complex therapy were prescribed "Resverazin" for 1 capsule 2 times a day. The course of treatment was 2 months.
Results and Discussion. The data obtained from our clinical studies served as the basis for introducing into the medical dentistry practice of generalized periodontitis (GP) phytopreparation "Resverazin". Inclusion in the complex therapy of patients with periodontitis of the drug "Resverazin" contributed to increase the effectiveness of the conducted etiotropic, pathogenetic and symptomatic treatment of patients, which provided clinically expressed signs of stabilization periodontitis and a faster transition of the GP in the stage of remission. Positive clinical outcome is based on the main criteria of effectiveness, which consisted in reducing the symptoms of inflammation – hyperemia, edema and hemopoiesis of the interdental papilla and marginal part of the gums. The tendency to reduce the signs of inflammation by clinical, subjective data, was confirmed by the positive dynamics of the prevalence rate of periodontal tissue inflammation (PTI). The decrease in the value of the integrative periodontal index is mainly due to the reduction in the severity of symptomatic gingivitis and the depth of the periodontal pockets. As a result of the treatment, the normalization of functional adaptive-compensatory responses occurs, which is confirmed by the normalization of indicators – the Green-Wermillion hygienic indices, the ON I-S, Silness-Loe, Stallard indexes and periodontal indexes: papillary-marginal alveolar (PMA ), bile density index by Muhlleman, periodontal index (PI).
Conclusions. The results of the clinical trial indicate the need for phytopreparations, in particular herbal remedy "Resveratrol", with anti-inflammatory, antiangiogenic, immunotropic, antioxidant action in the complex treatment of patients with generalized periodontitis.
References
Barer G.M., Zoryan, Ye.V. & Agapov, V.S. (2010). Ratsionalnaia farmakoterapiia v stomatologii [Rational pharmacotherapy in dentistry]. M. : Meditsina, 235-245 [in Russian].
Barna, O. (2013). Vse pro zdorov’ya bez mifiv [All about health without myths]. Health Medix, 1–2, 11-15 [in Ukrainian].
Bezrukova, I.V. (2005). Mikrobiologicheskiye i immunologicheskiye aspekty etiopatogeneza bystroprogressiruyushchego parodontita (obzor literatury) [Microbiological and immunological aspects of etiopathogenesis of fast-progressive periodontitis (review of literature)]. Parodontolohiia – Parodontology, 3, 22-25 [in Russian].
Grudyanov, A.I. & Moskalev, K.Ye. (2007). Biokhimicheskiye issledovaniya razlichnykh fiziologicheskikh sred i tkaney pri vospalitelnykh zabolevaniyakh parodonta (literaturnyy obzor) [Microbiological and immunological aspects of etiopathogenesis of fast-progressive periodontitis (review of literature)]. Parodontolohiia – Parodontology, 4 (6), 3-13 [in Russian].
Davidova, T.R., Karasenkova, Ya.M. & Khavkina, E.Yu. (2005). Do problemy disbakteriozu v stomatologichniy praktytsi [On the problem of dysbiosis in dental practice]. Stomatolohia – Stomatology, 2, 23-25 [in Ukrainian].
Danilevskiy, N.F. & Borisenko, A.V. (2000). Zabolevaniya parodonta. Kyiv : Zdorovia, 464 [in Ukrainian].
Zubachik, V.M., Dvulit, I.P. & Levitskiy, A.P. (2010). Vplyv bioflavanoidiv apelsyna na stan tkanyn porozhnyny rota za umov eksperymentalnoho parodontytu [The effect of orphan bioflavanoid on the condition of oral cavity tissues under experimental periodontitis conditions]. Novyny stomatolohii – News of dentistry, 4, 38-40 [in Ukrainian].
Ilicheva, T.N., Pronyayeva, T.R. & Shults, E.E. (2001). Immunostimuliruyushchaya aktivnost triterpenov rastitelnogo proiskhozhdeniya i ikh proizvodnykh [Immunostimulating activity of triterpenes of plant origin and their derivatives]. Zhurn. epidemiologii, mikrobiologii i immunologii – Journal of Epidemiology, Microbiology and Immunology, 2, 53-56 [in Russian].
Kankanyan, A.P. & Leontyev, V.K. (2010). Bolezni parodonta: Novyye podkhody v etiologii, patogeneze, diagnostike, profilaktike i lechenii [Periodontal Diseases: New Approaches to Etiology, Pathogenesis, Diagnosis, Prevention and Treatment]. Yer. : Tigran mets. 360 [in Russian].
Korshunov, V.M., Yefimov, B.A. & Pikina, A.P. (2000). Kharakteristika biologicheskikh preparatov i pishchevykh dobavok dlya funktsionalnogo pitaniya i korrektsiya mikroflory kishechnika [Characteristics of biological preparations and food additives for functional nutrition and correction of intestinal microflora]. Mikrobiologiya – Microbiology, 3, 86-91 [in Russian].
Kukes, V.G. (1999). Fitoterapiya s osnovami klinicheskoy farmakologii [Phytotherapy with the basics of clinical pharmacology]. M. : Meditsina. 189 [in Russian].
Lutskaya, I.K. (2010). Bolezni parodonta [Periodontal Diseases]. M. : Med. literature, 243 [in Russian].
Maydannik, V.G. Neratsionalnaya antibiotikoterapiya i antibiotikorezistentnost [Non-rational antibiotic therapy and antibiotic resistance]. Medicus Amicus, 5, 23-29 [in Russian].
Makarenko, O.A., Rossakhanova, L.N., Krisyun, I.I., Pustovoyt, Ye.P. & Dvulit, I.P. (2011). Antioksidantnyye svoystva bioflavanoidov tsitrusovykh [Antioxidant properties of citrus bioflavonoids]. Visnyk stomatolohii – Bulletin of Dentistry, 4, 26-27 [in Russian].
Mirchuk, B.N., Dragomiretska, M.S., Denga, O.V. & Levitskiy, A.P. (2007). Zastosuvannia fitoadaptoheniv u stomatolohii (Ohliad literatury) [Application of phytoadapthogens in dentistry (Literature review)]. Visnyk stomatolohii – Bulletin of Dentistry, 2, 62-66 [in Ukrainian].
Rudenko, V.V. (2005). Do problemy zapalnykh zakhvoriuvan porozhnyny rota [On the problem of inflammatory diseases of the cavity of the mouth]. Ukrainskii medychnyi chasopys – Ukrainian Medical Journal, 2 (46), 110-112 [in Ukrainian].
Baltina, L.A. (2007). Chemical modification of glycyrrizic acid as route to new bioactive compounds for medicine. Cum. Med. Chem., 41, 155-171.
Das, S. & Das, D.K. (2007). Anti-inflammatory responses of resveratrol. Inflamm Allergy Drug Targets, 6 (3), 168-173. Cardiovascular Research Center, University of Connecticut School of Medicine, Farmington, Connecticut 06030-1110, USA.
Khazaei, S. (2012). Resveratrol as a supplemental treatment for periodontitis, Dent Res J (Isfahan)., 9 (5), 655-657.
Surna, A., Sakalauskiene, J. & Vitkauskiene, A. (2009). Microbiological and biochemical characteristics of inflammatory tissues in the periodontium. Medicina (Kaunas), 44, 3, 201-210.
Downloads
Published
How to Cite
Issue
Section
License
Authors who sent their manuscript to "Вісник наукових досліджень. Bulletin of Scientific Research" Surgery agree to the following terms:
a. Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal. 
b. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
c. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access)
