COMPARATIVE TOXICOMETRY OF HETEROMETAL COMPLEXES OF GERMANIUM (IV) AND 3d-METALS BASED ON CITRIC AND TARTARIC ACID
DOI:
https://doi.org/10.11603/2415-8798.2017.4.8165Keywords:
toximetry, coordination compounds of germanium, copper, zinc, manganese, citric and tartaric acid.Abstract
The article represents the results of a comparative toxicometric analysis of six original coordination compounds of germanium (CСG) with various essential elements (zinc, copper, manganese) and biologic agents (citric and tartaric acid), which possess potential antihypoxic properties.
The aim of the study – to perform a comparative toxicometric analysis of new coordination compounds of germanium with essential elements based on citric and tartaric acids.
Results and Discussion. It was experimentally proved that the toxicity parameters LD 16, LD 50, LD 84, LD 99, which were studied by probit analysis, are totally different depend on an essential element or bioligands in their structure. It was shown that the main toxicophore is a metal, not an acid in heterometal complexes with different bioligands. According to LD 50 all investigated CCG are located in the next decreasing series: OKAHERM-5 (cuprum (II) tartratogermanate (IV))> OKAGERM-2 (cuprum (II) bis (citrate) germanate (IV))> OKAGERM 3 (zinc bis (citrate) germanate (IV))> OCAGERM-6 (zinc (II) tartratogermanate (IV))> OKAGERM-4 (manganese (II) tartrate germanate (IV))> OKAGERM-1 (manganese (II) bis (citrate) germanate (IV)). It was established that one intraperitoneal injection of all CCG possess low-toxicity and moderate toxicity to mammals, including humans, based on the extrapolation of experimental data using the constants of biological activity.
Conclusions. Our results are promising for the further pharmacological study of the most promising compound OKAGERM-4.
References
Ambrosov, I.V., Aleshin, S.V., Alimbarova, L.M., Matelo, S.K., & Shokhin, I.Ye. (2015). Ispolzovaniye organicheskikh soyedineniy germaniya v meditsine [Use of organic compounds of germanium in medicine]. Razrabotka i registratsi sredstv – Development and registration of medicines, (11), 144-152 [in Russian].
Menchikov, L.G., & Ignatenko, M.A. (2012). Biologicheskaya aktivnost organicheskikh soyedineniy germaniya (obzor) [Biological activity of organic compounds of germanium]. Khimiko-farmatsevticheskiy zhurnal – Himiko-pharmaceutical magazine, 46 (11), 3-6 [in Russian].
Kresyun, V.Y., Seyfullina, I.Y., & Hodovan, V.V. (2011). Perspektyvy stvorennia novykh likarskykh preparativ na osnovi kompleksnykh spoluk hermaniiu [Prospects for the creation of new drugs based on complex compounds of germanium]. Odeskyi medychnyi zhurnal – Odeidsky Journal of Medicine, (1), 31-35 [in Ukrainian].
Lukevits, E.Ya., Har, T.K. & Ignatovych, L.M. (1990). Biologicheskaya aktivnost soyedineniy germaniya [Biological activity of germanium compounds]. Zinatne. Riga, 1-191 [in Russian].
Lukyanchuk, V.D., Seyfullina, I.I., Posternak, G.I., Shebaldova, Ye.A., Risukhina, N.V., & Martsinko, Ye.E. (2014). Kislotno-osnovnoye sostoyaniye u zhivotnykh s gipoksiyey zamknutogo prostranstva na fone farmakoprofilaktiki novym koordinatsionnym soyedineniyem germaniya. [Acid-base state in animals with hypoxia of a closed space on the background of pharmacoprophylaxis by a new germanium coordination compound]. Medytsyna nevidkladnykh staniv – Medicine of urgent states, 1 (56), 67-70 [in Russian].
Lukyanchuk, V.D., Polishchuk, Yе.M., Seyfullina, I.Y., Posternak, H.I., Kravets, D.S., Rysukhina, N.V., & Martsynko, O.Yе. (2014). Kompleksna biokhemiliunestsentna otsinka tserebroprotektornoi efektyvnosti tserebrohermu na modeli zakrytoi cherepnomozkovoi travmy [Integrated biochemilunescence estimation of cerebroprotective efficiency of cerebogerm with a model of closed craniocerebral trauma.]. Medytsyna nevidkladnykh staniv – Medicine of urgent states, (6), 152-157 [in Ukrainian].
Lukyanchuk, V.D., Seyfullina, I.Y., Shebaldova, K.O., & Martsynko, O.E. (2015). Doslidzhennia aktoprotektornoi aktyvnosti novoho antyhipoksanta VITAHERM3 pislia perenesenoi hipoksii zamknutoho prostoru [Investigation of the actoprotective activity of the new antihypoxant VITAGERM3 after postponed hypoxia of the closed space]. Farmakolohiya ta likarska toksykolohiya – Pharmacology and drug toxicology, (1), 53-58 [in Ukrainian].
Nizhenkovska, I.V., Narokha, V.P., Kuznetsova, O.V., Bryuzhina, T.S., Seyfullina, I.Y., Martsynko, O.E., & Chebanenko, O.A. (2015). Vplyv nikotynovoi kysloty ta kompleksu hermaniiu z nikotynovoiu kyslotoiu (MIHU1) na zhyrnokyslotnyi sklad lipidiv kardiomiotsytiv i hepatotsytiv shchuriv z eksperymentalnoiu khronichnoiu sertsevoiu nedostatnistiu [Influence of nicotinic acid and germanium complex with nicotinic acid (MIGU1) on the fatty acid composition of lipids of cardiomyocytes and hepatocytes of rats with experimental chronic heart failure]. Farmakolohiya ta likarska toksykolohiya – Pharmacology and drug toxicology, (1), 68-75 [in Ukrainian].
Lukyanchuk, V.D., Polischuk, Ye.M., Seifullin I.Yu., Risihina N.V., Martsinko O.E., Chebanenko OA. (2015). The way of pharmacotherapy of a traumatic brain injury. The patent of Ukraine. No. 96363; (2015.01) A61K 33/00, G09B 23/00, filed. 02/14/2014.
Kresyun, V.Y., Luchyshyn, T.R., Seyfullina, I.Y., Rysukhina, N.V., & Lukyanchuk, V.D. (2012). Koordynatsiyni spoluky hermaniyu–potentsiyni zasoby zneshkodzhennia pry endotoksykozi [Coordination compounds of hermania-potential means of damage in endotoxicosis]. Zhurnal NAMN Ukrayiny – Journal of the Academy of Medical Sciences of Ukraine, 18(1), 120-125 [in Ukrainian].
Lukyanchuk, V.D., Savchenkova, L.V., Nemyatykh, O.D., Radionov, V.M. (2002). Poshuk ta eksperymentalne vyvchennia potentsiynykh protyhipoksychnykh zasobiv: metodychni rekomendatsiyi [Search and experimental study of potential anti-hypoxic drugs: methodical recommendations]. Kyiv: DFTS MOZ Ukrayiny, 1-27 [in Ukrainian].
Prozorovskiy, V.B. (1962). Ispolzovaniye metoda naimenshikh kvadratov dlya probit-analiza krivykh letalnosti [Use of the method of least squares for probit analysis of the curves of lethality]. Eksperimentalnaya i klinicheskaya farmakologiya – Pharmacology and Toxicology, 25 (1), 115-120 [in Russian].
BioStat [Ellectronic resourse]. – Access link: (date of circulation: August 15, 2017).
Rybolovlev, Yu.R., & Rybolovlev, R.S. (1979). Dozirovaniye veshchestv dlya mlekopitayushchikh po konstantam biologicheskoy aktivnosti [Dosage of substances for mammals according to the constants of biological activity.]. Doklady AN SSSR. – Report of the Academy of Sciences of the USSR, 247 (6), 1513-1516 [in Russian].
Sidorov, K.K. (1973). Toksikologiya novykh promyshlennykh khimicheskikh veshchestv [Toxicology of new industrial chemicals]. M. : Medgiz, 3, 1-47 [in Russian].
Izmerov, N.F., Sanotskiy, I.V., & Sidorov, K.K. (1977). Parametry toksikometrii promyshlennykh yadov pri odnokratnom vozdeystvii : (Spravochnik) [Parameters of toxicometry of industrial poisons under single exposure: reference book]. Meditsina, 240 [in Russian].
Downloads
Published
How to Cite
Issue
Section
License
Authors who sent their manuscript to "Вісник наукових досліджень. Bulletin of Scientific Research" Surgery agree to the following terms:
a. Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal. 
b. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
c. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access)
