THE ADVANTAGES OF IMMUNOCORRECTIVE THERAPY IN COMPLEX TREATMENT OF EXTERNAL GENITAL ENDOMETRIOSIS
DOI:
https://doi.org/10.11603/2415-8798.2016.3.6975Keywords:
external genital endometriosis, low molecular metabolic immunomodulator, gonadotropin-releasing hormone agonists.Abstract
The article reflects the results of clinical studies on the effect of immunomodulator 5-amino-1.2.3.4-tetrahydroftalazin-1.4-dione sodium salt on the outcome of external genital endometriosis’ treatment. Changes in the severity of pain, frequency and duration of relapses, female reproductive function, as well as humoral and cellular links of immunity (CD-3 CD-4 CD-8 CD-16 CD-22 cells) were followed. there were 66 patients with external genital endometriosis who were treated at the Department of Minimally Invasive surgery of ternopil University Hospital and the Department of operative Gynecology of ternopil Regional Clinical Perinatal Center "Mother and a Child". the control group consisted of 36 healthy women with the same age characteristics which were presented in the Department of Minimally Invasive surgery for surgical sterilization. examined patients were divided into two groups. First group consisted of 32 postoperative patients which received hormone therapy with gonadotropin-releasing hormone agonists (for 3-injection scheme). second group consisted of 34 patients which received immunocorrection with low molecular metabolic immunomodulator 5-amino-1.2.3.4-tetrahydroftalazin-1.4-dione sodium salt on the background of described therapy. Determination of the pain severity, menstrual flow dynamics, frequency and duration of relapses, the reproductive function of women were evaluated for assess treatment outcomes. Humoral and cellular links of immunity (CD-4 CD-16 CD-22 cells) from immunological laboratory methods were used. Patients were examined before and after treatment. Pain and symptoms of the disease were evaluated in points (on a Mac Laverty). Usage of low metabolic immunomodulator 5-amino-1.2.3.4-tetrahydroftalazin-1.4-dione sodium salt during complex treatment of mentioned pathology was proved. It was expressed by reducing complaints of dyspareunia, a clear manifestation of pain reduction, decreasing the frequency of relapses. the drug is indica ted for external genital endometriosis immuncorrection as a complex treatment, including hormone therapy with agonists gonad-releasing hormone and minimally invasive laparoscopic removal of endometrial cells, separation of adhesions. the proposed metabolic immunomodulator composition restore subpopulations of immune cells, mobilizes the reaction of cellular immunity, thus effectively providing immunotropic effect.References
Adamyan l. V. / l. V. adamyan, a. a. Osipova, M. M. sosnova // Problemy reproduktsii. – 2006. – № 5. – s. 11–15.
Burlev V. a. / V. a. burlev, a. V. burlev // Problemy reproduktsii. – 2007. – № 2. – s. 45–51.
Peresada O. a. Klinika, diagnostika i lecheniye genital'nogo endometrioza : ucheb. posob. / O. a. Peresada. – Minsk : bel. Nauka, 2001. – 274 s.
Dubossarskaya Z. M. aktual'nyye problemy endometrioidnoy bolezni // Meditsinskiye aspekty zdorov'ya zhenshchiny. – № 2. – 2006. – s. 4–7.
Sol'skiy s. YA. Diskussionnyye voprosy diagnostiki i lecheniya naruzhnogo genital'nogo endometrioza / s. YA. Sol'skiy // ZHínochiy líkar. – № 1(9). – 2007. – s. 24–25.
Downloads
Published
How to Cite
Issue
Section
License
Authors who sent their manuscript to "Вісник наукових досліджень. Bulletin of Scientific Research" Surgery agree to the following terms:
a. Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal. 
b. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
c. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access)
