THE LEVEL OF SERUM AMYLOID A IN COPD PATIENTS
DOI:
https://doi.org/10.11603/2415-8798.2016.3.6965Keywords:
chronic obstructive pulmonary disease, systemic inflammation, serum amyloid A.Abstract
We investigated biomarker of systemic inflammation – serum amyloid A (SAA) in 37 stable COPD patients. The level of the SAA in COPD patients was significantly higher than in the control group (р=0.035). In patients with SAA level more than 182.34 pg/mL was higher severity of symptoms according to the CAT (р = 0,030) questionnaire and lower level of FEV1(р = 0,020) than in patients with the same level of the SAA as in control group. The degree of obstructive disorders in COPD patients may be associated with the severity of systemic inflammation. Severity of symptoms is higher in COPD patients with high level of SAA than in patients with low level of the SAA.References
Pro zatverdzhennya ta vprovadzhennya medyko-tekhnolohichnykh dokumentiv zi standartyzatsiyi medychnoyi dopomohy pry khronichnomu obstruktyvnomu zakhvoryuvanni lehenʹ : nakaz MOZ Ukrayiny № 555 vid 27.06.2013 r. – Kyyiv, 2013. – 146 s.
Abo Sabe S. Serum amyloid a in chronic obstructive pulmonary disease / S. Abo Sabe, B. W. Abo Bakr// AAMJ. – 2008. – Vol. 6. – P. 27–34.
Serum amyloid A is a biomarker of acute exacerbation of COPD / S. Bozinovski, A. Hutchinson, M. Thompson [et al.] // Am. J. Respir. Crit. Care Med. – 2007. – Vol. 177. – P. 269–278.
Association between chronic obstructive pulmonary diseaseand systemic inflammation: a systematic review and a metaanalysis / W. Q. Gan, S. F. Man, A. Senthilselvan // Thorax. – 2004. – Vol. 59. – P. 574–580.
Global Initiative for Chronic Obstructive Lung Disease (Updated 2010) // Electronic Resourses:www.goldcopd.com
Reduced soluble receptor for advanced glycation end-products in COPD / S. T. Smith, D. J. Yerkovich, M. A. Towers, M. L. Carroll // Eur. Respir. J. – 2011. –Vol. 37. – P. 516–522.
Downloads
Published
How to Cite
Issue
Section
License
Authors who sent their manuscript to "Вісник наукових досліджень. Bulletin of Scientific Research" Surgery agree to the following terms:
a. Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
b. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
c. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access)