THE OPTIMIZING TREATMENT OF THE DIASTOLIC HEART FAILURE IN HYPERTENSIVE PATIENTS IN THE SIMULTANEITY-HYPERURICEMIA

Authors

  • M. V. Hrebenyk I.Ya. Horbachevsky Ternopil State Medical University
  • O. I. Kotsiuba I.Ya. Horbachevsky Ternopil State Medical University

DOI:

https://doi.org/10.11603/2415-8798.2016.3.6959

Keywords:

arterial hypertension, left ventricle diastolic dysfunction, hyperuricemia, Lisinopril, Valsartan.

Abstract

The effect of the combined antihypertensive treatment with Lisinopril or Valsartan on the left ventricle diastolic dysfunction (LVDD) was compared in hypertensive patients depending on the uric acid level. 137 patients with the second stage and 2 and 3 degrees of arterial hypertension (AH) were observed, 74 patients among them had concomitant symptom – free hyperuricemia (basic group) and 63 had normal uric acid (UA) blood level (comparing group). the LVDD was determined in 84.8 % of patients with the increased UA level, and in 53.9 % of normouricemia patients. the direct correlation between the LVDD index e/e’ and UA level was determined, which proves the more often association of hyperuricemia and left ventricle diastolic function disturbances in hypertensive patients. Besides we determined, that the UA level was on 12.7 % (р<0.05) higher in patients with LVDD than in patients with the preserved ejection fraction. In the same time, the UA level in patients with pseudonormal type of LVDD was higher than in patients with relaxation type. After the 6 months treatment the antihypertensive effect of the combined therapy, including Lisinopril was achieved in 81.7 % patients, and including Valsartan – in 82.8 % of observed patients. In Valsartan group after the 6 months treatment the more significant improvement of the LVDD was determined in both normo- and hyperuricemia patients. In hyperuricemia patients treated with Valsartan the e/e’ decreased on 9.5 % comparing with initial index. This can be the evidence of more significant approving effect of valsartan on the LVDD in comparison with liisinopril.the effect of Valsartan on the decreasing of hyperuricemia level was found to be more marked than that of Lisinopril.

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Published

2016-11-23

How to Cite

Hrebenyk, M. V., & Kotsiuba, O. I. (2016). THE OPTIMIZING TREATMENT OF THE DIASTOLIC HEART FAILURE IN HYPERTENSIVE PATIENTS IN THE SIMULTANEITY-HYPERURICEMIA. Bulletin of Scientific Research, (3). https://doi.org/10.11603/2415-8798.2016.3.6959

Issue

No. 3 (2016)

Section

INTERNAL MEDICINE

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