HCV-INFECTION AND LYMPHOPROLIFERATION (LITERATURE REVIEW)

Authors

  • V. V. Potii Donetsk National Medical University
  • I. A. Zaitsev Bogomolets National Medical University
  • V. T. Kiriienko Bogomolets National Medical University
  • O. I. Hlukhova Bogomolets National Medical University
  • S. Yu. Hryshchenko Bogomolets National Medical University

DOI:

https://doi.org/10.11603/2415-8798.2016.3.6958

Keywords:

HCV-infection, lymphoproliferation, B-cell non-Hodgkin’s lymphoma, cryoglobulinemia, cryoglobulinemic syndrome.

Abstract

The article describes the role of HCV-infection in the development of lymphoproliferative disorders, some elements of the pathogenesis of extrahepatic manifestations, such as autoimmune disorders and non-Hodgkin's lymphoma (NHL) associated with HCV infection. Mixed cryoglobulinemia is the most common condition associated with HCV-induced lymphoproliferation and in some cases can lead to clinical manifestations such as hemorrhagic vasculitis, purpura, arthralgia, etc., as well as the development of В-cell NHL. HCV-lymphogenesis is based on continuous B-cell activation and inhibition of B-cell apoptosis, which is likely to play a key role in the development of extrahepatic manifestations associated with HCV-infection.

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Published

2016-11-23

How to Cite

Potii, V. V., Zaitsev, I. A., Kiriienko, V. T., Hlukhova, O. I., & Hryshchenko, S. Y. (2016). HCV-INFECTION AND LYMPHOPROLIFERATION (LITERATURE REVIEW). Bulletin of Scientific Research, (3). https://doi.org/10.11603/2415-8798.2016.3.6958

Issue

Section

REVIEWS AND ORIGINAL RESEARCH