HCV-INFECTION AND LYMPHOPROLIFERATION (LITERATURE REVIEW)
DOI:
https://doi.org/10.11603/2415-8798.2016.3.6958Keywords:
HCV-infection, lymphoproliferation, B-cell non-Hodgkin’s lymphoma, cryoglobulinemia, cryoglobulinemic syndrome.Abstract
The article describes the role of HCV-infection in the development of lymphoproliferative disorders, some elements of the pathogenesis of extrahepatic manifestations, such as autoimmune disorders and non-Hodgkin's lymphoma (NHL) associated with HCV infection. Mixed cryoglobulinemia is the most common condition associated with HCV-induced lymphoproliferation and in some cases can lead to clinical manifestations such as hemorrhagic vasculitis, purpura, arthralgia, etc., as well as the development of В-cell NHL. HCV-lymphogenesis is based on continuous B-cell activation and inhibition of B-cell apoptosis, which is likely to play a key role in the development of extrahepatic manifestations associated with HCV-infection.References
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