THE IMPACT OF HIV VIRAL LOAD ON THE SURVIVAL OF PATIENTS WITH HIV INFECTION DURING А 5-YEAR FOLLOW-UP

Authors

  • O. V. Shevelоva Dnipropetrovsk Medical Academy of Health Ministry of Ukraine, Dnipro, Ukraine
  • L. R. Shostakovych-Koretskaya Dnipropetrovsk Medical Academy of Health Ministry of Ukraine, Dnipro, Ukraine
  • K. Yu. Lytvyn Dnipropetrovsk Medical Academy of Health Ministry of Ukraine, Dnipro, Ukraine

DOI:

https://doi.org/10.11603/1681-2786.2018.2.9363

Keywords:

HIV, HAART, CD4 T-lymphocytes, viral load.

Abstract

Purpose: based on a 5-year follow-up of a cohort of HIV-infected patients who were assigned highly active antiretroviral therapy, to assess the impact of viral load of HIV and CD4 RNA on the beginning of highly active antiretroviral therapy on mortality.

Materials and Methods. The analysis of patients was carried out taking into account clinical and laboratory parameters. Mathematical and statistical methods were used: descriptive statistics of quantitative data in groups; correlation analysis (correlation coefficient – rs).

Results. All patients received highly active antiretroviral therapy (HAART) for at least 5 years. Immunophenotyping of peripheral blood showed the following results: median (IU, 25–75 percentile) CD4 + level was 186 (90–262) copies / ml, viral load-75.358 (19.091–326.273) RNA HIV copies/ml. Over five years of follow-up, 63 patients died. If we take into account the annual mortality, a large percentage of HIV patients died in the first 12 months of treatment and amounted to 58.73%. Over the next two years, 11.11 % and 14.28 % died annually, respectively. In the fourth year after the start of highly active antiretroviral therapy, 11.11 % of patients died. For the 5th year of the HAART died 4.76 % of patients.

Сonclusions. In HIV-infected patients, who were assigned HAART to, there is a certain relationship between the number of t-lymphocytes-helpers and viral load (rs=-0.821; p=0.000) during the 5-year follow-up. The highest accumulated risk of death – 0.1, was found in groups of patients with a greater degree of immunosuppression.

References

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Published

2018-09-27

How to Cite

Shevelоva O. V., Shostakovych-Koretskaya, L. R., & Lytvyn, K. Y. (2018). THE IMPACT OF HIV VIRAL LOAD ON THE SURVIVAL OF PATIENTS WITH HIV INFECTION DURING А 5-YEAR FOLLOW-UP. Bulletin of Social Hygiene and Health Protection Organization of Ukraine, (2). https://doi.org/10.11603/1681-2786.2018.2.9363

Issue

No. 2 (2018)

Section

Health of the population:tendencies and forecasts

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