PARTICULARITIES OF COGNITIVE FUNCTION DISTURBANCES IN PATIENTS WITH HIV INFECTION, WHO ARE FOLLOWED AT OUTPATIENT BASIS

Authors

  • L. R. Shostakovych-Koretskaia Dnipropetrovsk Medical Academy of Ministry of Health of Ukraine, Dnipro, Ukraine
  • K. Yu. Lytvyn Dnipropetrovsk Medical Academy of Ministry of Health of Ukraine, Dnipro, Ukraine
  • O. O. Bilokon Dnipropetrovsk Medical Academy of Ministry of Health of Ukraine, Dnipro, Ukraine
  • I. P. Mishkoi «Dnipropetrovsk Regional Centre for the Prevention and Management of AIDS», Dnipro, Ukraine.
  • I. V. Chukhalova «Dnipropetrovsk Regional Centre for the Prevention and Management of AIDS», Dnipro, Ukraine.
  • O. O. Lesnycha Prof. Ye. Popkov Dnipropetrovsk Municipal Clinical Hospital No. 21, Dnipropetrovsk Municipal Centre for the Prevention and Management of AIDS, Dnipro, Ukraine.

DOI:

https://doi.org/10.11603/1681-2786.2018.1.9234

Keywords:

HIV infection, cognitive impairment, antiretroviral therapy, substitution maintenance therapy.

Abstract

Purpose: to determine the presence of cognitive impairment and factors of possible influence on the cognitive function among HIV patients who are under the outpatient follow-up.

Materials and Methods. The study involved 95 patients of age with confirmed HIV infection without clinical signs of CNS diseases. The assessment of the mental status was carried out on the basis of two tests: MMSE and “drawing of the clock”.

Results. It was found that the decrease in the frequency of cognitive disorders correlated with the duration of ART - the correlation coefficient for the score on the MMSE scale was rs=+0.27, p <0.01, for the “clock drawing” test - rs=+0.22, p <0.05. There was a tendency to increase of the incidence of cognitive impairment at the use of efavirenz. It has been established that the use of substitution maintenance therapy (methadone) in drug users reduced the relative risk of developing cognitive impairment (p <0.01). The presence of a probable connection with the viral load in dynamics (rs=-0.20, p <0.05 for the MMSE test) has been determined.

Conclusions. Disturbances of cognitive function occur in patients with HIV infection at an early stage of HIV infection.

References

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Published

2018-07-17

How to Cite

Shostakovych-Koretskaia, L. R., Lytvyn, K. Y., Bilokon, O. O., Mishkoi, I. P., Chukhalova, I. V., & Lesnycha, O. O. (2018). PARTICULARITIES OF COGNITIVE FUNCTION DISTURBANCES IN PATIENTS WITH HIV INFECTION, WHO ARE FOLLOWED AT OUTPATIENT BASIS. Bulletin of Social Hygiene and Health Protection Organization of Ukraine, (1). https://doi.org/10.11603/1681-2786.2018.1.9234

Issue

No. 1 (2018)

Section

Health of the population:tendencies and forecasts

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