ANTIOXIDANT THERAPY IN WOMEN WITH INFERTILITY OF GENITAL ENDOMETRIOSIS
DOI:
https://doi.org/10.11603/1681-2786.2017.4.8663Keywords:
endometriosis oxidative stress, antioxidants, infertility, pelvic pain, hormonal imbalance.Abstract
Purpose: to analyze the literature review data on the effect of oxidative stress on the quality of eggs in infertile women against the background of genital endometriosis and the main principles of antioxidant therapy.
Materials and Methods. The bibliosemantic method was used in the study – 37 sources of scientific literature were analyzed.
Results. Based on the materials used, scientific research has established the direct effect of oxidative stress on the quality of eggs and embryos and the effect of antioxidants on different parts of the pathogenesis of oxidative stress. The effect of oxidative stress on the development of symptoms of endometriosis and the feasibility of the use of antioxidants as an auxiliary direction for the treatment of endometriosis associated infertility.
Conclusions. Oxidative stress is one of the causes of endometriosis associated with infertility. Receiving antioxidant drugs reduces oxidative stress and improves the quality of eggs and embryos, and therefore the results of treatment of infertility.References
Adamyan, L.V. & Andreyeva, Ye.N. (2007). Genitalnyy endometrioz: klinika, diagnostika, lecheniye: Metod. Rekomendatsii [Genital endometriosis: clinic, diagnosis, treatment: Method. recommendations]. Moscow: Nauch. tsentr akusherstva, ginekologii i perinatologii [in Russian].
Adamyan, L.V., Burgova, Ye.N., Serezhenkov, V.A., Sonova, M.M., Osipova, A.A. & Arslanyan, K.N. (2009). Rol zhelezosvyazyvayushchikh belkov krovi v antioksidantnoy zashchite i ikh svyaz s genitalnym endometriozom [The role of iron-binding proteins of blood in antioxidant defense and their relationship with genital endometriosis]. Akusherstvo i ginekologiya – Obstetrics and Gynecology, 5, 37-41 [in Russian].
Agarwal, A., Gupta, S. & Sharma, R. (2005). Oxidative stress and its implications in female infertility − a clinician’s perspective. Reproductive BioMedicine, 641-650.
Agarwal, A., Aziz, N. & Rizk B. (2013). Studies on Women's Health. Human Press, New York.
Santanam, N., Kavtaradze, N., Murphy, A., Dominguez, C., & Parthasarathy S. (2013). Antioxidant supplementation reduces endometriosisrelated pelvic pain in humans. Transl. Res., 161 (3), 189-195.
Bedaiwy, M.A. & Falcone, T. (2003). Peritoneal fluid environment in endometriosis. Clinicopathological implications. Minerva Ginecol., 55, 333-345.
Bulun, S. E. (2009). Endometriosis. N. Engl. J. Med., 360 (3), 268-279.
Bulun, S. E. & Fujji, S. (1991). Secondary mullerian system and endometriosis. Am. J. Obstet. Gynecol., 165, 219-225.
Chiu, T.T.Y., Rogers, M.S., Briton-Jones, C. & Haines, C. (2003). Effects of myo−inositol on the in-vitro maturation and subsequentdevelopment of mouse oocytes. Human Reproduction, 18, 2, 408-416.
Falasca M. & Maffucci, T. (2009). Rethinking phosphatidylinositol 3-monophosphate. Biochimica et Biophysica Acta-Molecular Cell Research, 1793, 12, 1795-1803.
Chiu, T.T.Y., Rogers, M.S., Law, E.L.K., Briton-Jones, C.M., Cheung, L.P. & Haines, C.J. (2002). Follicular fluid and serumconcentrations of myo-inositol in patients undergoing IVF:relationship with oocyte quality,” Human Reproduction, 17, 6, 1591-1596.
Giudice, L.C. (2010). Clinical Practice: Endometriosis. N. Engl. J. Med., 362, 2389-2398.
Ho, H.N., Wu, M.Y., & Chen, S.U. (1997). Total antioxidant status and nitric oxide do not increase in peritoneal fl uids from women with endometriosis. Human Reproduction, 2810-2815.
Goud, P.T., Goud, A.P. & Leybaert, L. (2002). Inositol 1, 4, 5- trisphosphate receptor function in human oocytes: calcium responses and oocyte activation-related phenomena induced by photolytic release of InsP3 are blocked by a specific antibody to the type I receptor. Molecular Human Reproduction, 8, 10, 912-918.
Lambrinoudaki, I.V., Augoulea, A. & Christodoulakos, G.E. (2009). Measurable serum markers of oxidative stress response in women with endometriosis. Fertil. Steril, 91, 46-50.
Larner, J., Brautigan, D.L. & Thorner, M.O. (2010). D-chiro-inositol glycans in insulin signaling and insulin resistance. Molecular Medicine, 16, 11-12, 543-551.
Lasco, A., Catalano, A. & Benvenga, S. (2012). Improvement of primary dysmenorrhea caused by a single oral dose of vitamin D: results of a randomized, doubleblind, placebo-controlled study. Arch. Intern. Med., 172, 366-367.
Murphy, A.A., Santanam, N., Morales, A.J., & Parthasarathy, S. (2008). Lysophosphatidyl choline, a chemotactic factor for monocytes/T-lymphocytes is elevated in endometriosis. J Clin. Endocrinol. Metabol., 83, 2110-2113.
Mehlmann, L.M. & Kline, D. (1994). Regulation of intracellular calciumin the mouse egg: calcium release in response to sperm or inositol trisphosphate is enhanced after meiotic maturation. Biology of Reproduction, 51, 6, 1088-1098.
Mitsube, K., Zackrisson, U. & Brannstrom, M. (2002). Niric oxide regulates ovarian blood flow in the rat during the periovulatory period. Hum. Reprod., 17, 2509-2516.
Shen, X., Xiao, H., Ranallo, R., Wu, W.-H. & Wu, C. (2003). Modulation of ATP-dependent chromatin-remodeling complexes byinositol polyphosphates. Science, 299, 5603, 112-114.
Ota, H., Igarashi, S., Hatazawa, J. & Tanaka, T. (1999). Immunohistochemical assessment of superoxide dismutase expression in the endometrium in endometriosis and adenomyosis. Fertil. Steril, 72, 129-134.
Nestler, J.E., Jakubowicz, D.J., Reamer, P., Gunn, R.D. & Allan, G. (1999). Ovulatory and metabolic effects of D-chiro-inositol in the polycystic ovary syndrome. N. Engl. J. Med., 340 (17), 1314-1320.
Pacher, P., Beckman, J. S. & Liaudet, L. (2007). Nitric oxide and peroxynitrite in health and disease. Physiol. Rev., 87, 1, 315-424.
Nap, A.W., Groothuis, P.G., Demir, A.Y., Evers, J.L. & Dunselman, G.A. (2004). Pathogenesis of endometriosis. Best Pract. Res. Clin. Obstet. Gynaecol., 18, 233-244.
Gentilini, D., Busacca, M., Di Francesco, S., Vignali, M., Viganò, P., Di Blasio A.M. (2007). PI3K/Akt and ERK1/2 signalling pathways are involved in endometrial cell migration induced by 17beta-estradiol and growth factors. Mol. Hum. Reprod., 13, 317-322.
Reiter, R.J., Tan, D.X. & Maldonado M.D. (2005). Melatonin as an antioxidant: physiology versus pharmacology. J. Pineal Res., 39, 215-216.
Savaris, A.L. & do Amaral V.F. (2011). Nutrient intake, anthropometric data and
correlations with the systemic antioxidant capacity of women with pelvic
endometriosis. Eur. J. Obstet. Gynecol. Reprod. Biol., 158, 314-318.
Shanti, A. & Santanam, N. (1999). Autoantibodies to markers of oxidative stress are elevated in women with endometriosis. Fertil. Steril., 71, 1115-1118.
Singh, A.K., Chattopadhyay, R., Chakravarty, B. & Chaudhury, K. (2013). Altered circulating levels of matrix metalloproteinases 2 and 9 and their inhibitors and effect of progesterone supplementation in women with endometriosis undergoing in vitro fertilization. Fertil. Steril., 100 (1), 127-134. e121.
Mecha, E., Omwadho, C.O.A., Zoltan, D., Tinneberg, H.R. & Konrad L. (2012). TGF-βs induce smad-dependent signaling and apoptosis in human endometrial and endometriotic cells. Abstracts from 1 st European Congress of Endometriosis. Siena-Italy.
Stachecki, J.J. & Armant, D.R. (1996). Transient release of calcium from inositol 1, 4, 5-triphosphate specific store, regulates mouse preimplantation development. Development, 122, 2485-2496.
Trujillo, E, Davis, C. & Milner, J. (2006). Nutrigenomics, proteomics, metabolomics, and the practice of dietetics. J. Am. Diet Assoc., 106, 403-413.
Van Langendonckt, A., Casanas-Roux, F. & Donnez, J. (2002). Oxidative stress and peritoneal endometriosis. Fertil. Steril., 77, 861-870.
Waller, K.G., Lindsay, P. & Curtis, R.W. (1993). The prevalence of endometriosis in women with infertile partners. Eur. J. Obstet. Gynecol. Reprod. Biol., 48, 135-139.
Mier-Cabrera, J., Aburto-Soto, T., Burrola-Méndez, S., Jiménez-Zamudio, L.,
Tolentino, M.C. & Casanueva, E. (2009). Women with endometriosis improved
their peripheral antioxidant markers after the application of a high antioxidant diet. Reprod. Biol. Endocrinol., 7, 54.
Yang, W.C., Chen, H.W. & Au, H.K. (2004). Serum and endometrial markers. Best Pract. Res. Clin. Obstet. Gynecol., 18, 306-318.
Downloads
Published
How to Cite
Issue
Section
License
Authors who publish in this journal agree to the following terms:
1. The authors reserve the right to authorship of the work and pass the journal right of first publication of this work is licensed under a Creative Commons Attribution License, which allows others to freely distribute the work published with reference to the authors of the original work and the first publication of this magazine.
2. Authors are entitled to enter into a separate agreement on additional non-exclusive distribution of work in the form in which it was published in the magazine (eg work place in the electronic repository institution or publish monographs in part), provided that the reference to the first publication of this magazine.
3. Policy magazine allows and encourages authors placement on the Internet (eg, in storage facilities or on personal websites) manuscript of how to submit the manuscript to the editor and during his editorial processing, since it contributes to productive scientific discussion and positive impact on the efficiency and dynamics of citing published work (see. The Effect of Open Access).