PREGRAVIDARY PREPARATION OF PATIENTS WITH SYNDROME OF POLYCASTOSIS OVARIANS IN PROGRAMS OF EXTRACORPORAL FERTILIZATION

Authors

  • M. S. Khmil I. Horbachevsky Ternopil State Medical University

DOI:

https://doi.org/10.11603/1681-2786.2017.4.8650

Keywords:

polycystic ovary syndrome, infertility, controlled ovarian stimulation, oocyte quality, FT-500 Plus, inositol, vitamin D3.

Abstract

Purpose: evaluation of the effectiveness of polycystic ovary syndrome pre-treatment before controlled ovarian stimulation in assisted reproductive technologyin patients with polycystic ovary syndrome.

Materials and Methods: A randomized controlled trial was conducted among 146 women with polycystic ovary syndrome. In the study, we used general clinical, embryological and hormonal methods of examination, ultrasound examination was also used.

Results. Based on our own research, it was found that patients who were using complex pregravidary training in assisted reproductive technologies had significantly higher oocytes quality, frequency of embryo fragmentation and a high percentage of blastocysts obtained, and that the use of cryoprotocolol increased the incidence of pregnancy .

Conclusions. Polycystic ovary syndrome pre-treatment in vitro fertilization protocols improves the quality of oocytes, increases the pregnancy onset rates, reduces manifestations of metabolic syndrome.

References

Goncharov, N.P. (1996). Androgeny (lektsiya) [Androgens (lecture)]. Problemy endokrinologii – Problems of Endocrinology, 4, 28-31 [in Russian].

Grodnitskaya, Ye.E. & Kurtser, M.A. (2015). Defitsit vitamina D u zhenshchin s sindromom polikistoznykh yaichnikov [Deficiency Vitamin D in women with polycystic ovary syndrome]. Problemy reproduktsii – Problems of Reproduction, 21 (5), 38-42 [in Russian].

Gromova, O.A., Torshin, I.Yu. & Limanova, O.A. (2013). Sistematicheskiy analíz molekulyarno-fiziologicheskikh effektov mio-inozitla – dannyye molekulyarnoy biologii, eksperementalnoy i klinicheskoy meditsiny [Systematic analysis of molecular-physiological effects of myo-inositol - dannemolecular biology, experimental and clinical medicine.]. Effektivnaya farmakoterapiya v akusherstve ginekologii – Effective Pharmacotherapy in Obstetrics and Gynecology, 8, 37-43 [in Russian].

Guriyev, T.D. (2010). Sindrom polikistoznykh yaichnikov [Polycystic ovary syndrome]. Ausherstvo, Ginekologiya, Reproduktsiya – Ausherstvo, Gynecology, Reproduction, 4, 2, 10-15 [in Russian].

Nazarenko, T.A. (2005). Sindrom polikistoznykh yaichnikov. Sovremennyye podkhody k diagnostike i lecheniyu besplodiya [Syndrome of polycystic ovaries. Modern approaches to diagnosis and treatment offertility]. Moscow: MEDpress-inform [in Russian].

Tatarchuk, T.F., Bulavenko, O.V., Kapshuk, I.M. & Tarnopolska, V.O. (2015). Nedostatnist vitaminu D v henezi porushen reproduktyvnoho zdorovia [Vitamin D deficiency in the genesis of reproductive health disorders]. Ukrayinskyi medychnyi chasopys – Ukrainian Medical Journal, 5 (109), 56-60 [in Ukrainian].

Podzolkova, N.M. & Koloda, Yu.A. (2016). Sovremennye predstavlenyya o syndrome polykystoznykh yaychnykov [Modern presentations about the syndrome of polycystic lesions]. Farmateka – Pharmacy, 3, 8-15 [in Russian].

Nakaz Ministerstva okhorony zdorovia Ukrainy vid 09.09.2013r. «Pro zatverdzhennia Poriadku zastosuvannia dopomizhnykh reproduktyvnykh tekhnolohii v Ukraiini» [Order of the Ministry of Health of Ukraine dated 09.09.2013. "On Approval of the Procedure for the Application of Assisted Reproductive Technologies in Ukraine"]. [in Ukrainian].

Nakaz Ministerstva okhorony zdorovia Ukrainy vid 09.09.2013r. № 1030/102 «Pro udoskonalennia systemy planuvannia simi ta okhorony reproduktyvnoho zdorovya v Ukraini» [Order of the Ministry of Health of Ukraine of 11/29/2013. №1030 / 102 "On Improvement of Family Planning and Reproductive Health System in Ukraine"]. [in Ukrainian].

Sobolev, Ye.L., Zlatima, Ye.A. & Potin, V.V. (2006). Agonisty gonadotropin-ripizinggormona v sochetanii s nizkodozirovannymi estrogen-gestagennymi oralnymi kontratseptivami v terapii SPKYA [Gonadotropin-Ripinghormone agonists in combination with low-dose estrogen-gestagenic oral contraceptives in therapy of PCOS]. Akusherstvo i ginekologiya – Obstetrics and Gynecology, 1, 25-31 [in Russian].

Chebotnykova, T.V. & Kholodova, Zh.L. (2008). Syndrom polykystoznykh yaichnikov: uchebno-metodicheskoe posobye [Polycystic ocular syndrome: educational and methodical manual]. (Ed.) Y.Y. Dedova. Moscow [in Russian].

Carmіna, E. & Lobo, R.A. (1997). Gonadotropin–relezing-hormone agonist therapy for hirsutizmas effective a shigh do secyproterone acetate but results in alonger remission. Ibid 12, 4, 663-666.

Chunla, He. (2015). Serum vitamin D levels and polycystic ovary syndrome: A systematic review and meta-analysis. Nutrients, 7 (6), 4555-4577. doi: 10.3390/nu7064555

Angioni S. (2004). Correlation of ovarian stromal hypertrophy to hyperandrogenism and insulin resistance in young women with PCOS. Presented at the 11-th World Congress of Gynecological Endocrinology Florence, 18, 1, 163-164.

David K. Gardner, D.Phil., Michelle Lane, Ph.D., John Stevens, M.T., Terry Schlenker, M.A., & William B. Schoolcraft, M.D. (2000). Blastocyst score affects implantation and pregnancy outcome: towards a single blastocyst transfer. Fertility and Sterility, 6, (73), 1155-1158.

Garg, D. & Tal R. (2016). Inositol Treatment and ART Outcomesin Womenwith PCOS. International Journal of Endocrinology, ID1979654, 9 pages.

MAFM, Y., Vander Veen, F., Al-Inany, H.G., Mochtar, M.H., Griesinger, G., Nagi Mohesen, M., Aboulfoutouh, I. & van Wely, M. (2014). Gonadotropin-releasing hormoneagonistversus HCG foroocytetriggeringin antagonist-assisted reproductivetechnology. Cochrane Database of Systematic Reviews, 10, 1-73.

Irani, M. & Merhi, Z. (2014). Role of vitamin D in ovarian physiology and its implication in reproduction: a systematic review. Fertil Steril., 102 (2), 460-468.

Lazzaroni-Tealdi, E., Barad, D.H., Albertini, D.F., Yu, Ya., Kushnir, V.A., Russell, H. … Gleicher, N. (2015). Oocyte scoring enhances embryo-scoring in predicting pregnancy chances with IVF where it counts most. Plos One, 2, 1-13. DOI:10.1371/journal.

(2002). Population Reference Bureau World population data sheet of the population reference bureau: demographic data and estimates for the countries and regions of the world. Washington, DC: Population Reference Bureau, p. 548.

Zhoumeng, Ch., Lin, H., Wagner Robb, S., & Ezeamama, A.E. (2015). Review and Meta-Analysis. Nutrients, 7, р 4555-4577. doi:10.3390/nu7064555.

Rienzi, L., Vajta, G. & Ubaldi, F. (2011). Predictive value of oocyte morphology in human IVF: a systematic review of the literature. Human Reprodn Update, 17, 1, 34-45.

Tehrani, H., Mostajeran, F. & Shahsavari, S. (2014). The effect of calcium and Vitamin D supplementation on menstrual cycle, body mass index and hyper and rogenism state of women with polycysticovarian syndrome: a clinical trial study. J. Res. Med. Sci., 19, 875-880.

Published

2018-03-15

How to Cite

Khmil, M. S. (2018). PREGRAVIDARY PREPARATION OF PATIENTS WITH SYNDROME OF POLYCASTOSIS OVARIANS IN PROGRAMS OF EXTRACORPORAL FERTILIZATION. Bulletin of Social Hygiene and Health Protection Organization of Ukraine, (4). https://doi.org/10.11603/1681-2786.2017.4.8650

Issue

Section

Health of the population:tendencies and forecasts