PATHOGENETIC INTERSECTIONS OF POLYCYSTIC OVARY SYNDROME AND METABOLIC SYNDROME IN WOMEN WITH INFERTILITY

(LITERATURE REVIEW)

Authors

  • S. V. Khmil I. Horbachevsky Ternopil National Medical University, Ternopil, Ukraine
  • Yu. B. Pravak I. Horbachevsky Ternopil National Medical University, Ternopil, Ukraine

DOI:

https://doi.org/10.11603/1681-2786.2024.1.14631

Keywords:

infertility, PCOS, metabolic syndrome, anovulation, insulin resistance, assisted reproductive technologies, in vitro fertilisation, steroid hormones, obesity, pregnancy

Abstract

Purpose: to determine the characteristics and potential obstetric consequences of the combined course of polycystic ovary syndrome and metabolic syndrome in infertility in young women with unrealized reproductive potential.

Materials and Methods. A systematic review and comparative analysis of 25 scientific publications and literature sources from the PubMed database over the past 5 years related to research in the field of reproductive medicine on the impact of polycystic ovary syndrome and metabolic syndrome on the development of infertility in women of reproductive age and on pregnancy.

Results. The literature review revealed a number of common links in the pathogenesis of PCOS and metabolic syndrome in women with infertility and other fertility disorders. Recent studies recommend classifying PCOS into two subtypes: reproductive and metabolic. Insulin resistance plays a key role in the development of PCOS. The pathological circle is also closed by hyperandrogenism and obesity. It is the defective steroidogenesis that provokes the development of various metabolic disorders, which are quite heterogeneous, and together, insulin resistance, visceral obesity, dyslipidemia, and hyperandrogenism present in PCOS can be classified as a metabolic syndrome. Some issues related to infertility management in PCOS and metabolic syndrome are highly debatable and controversial, as indicated by authors from around the world.

Conclusions. Polycystic ovary syndrome is a kind of platform for the development of many comorbid pathologies. The quality of life of such patients, their reproductive and somatic health, and the realization of reproductive plans directly depend on the management of all existing manifestations of the pathology. The approach to the diagnosis and treatment of women of reproductive age with fertility problems, infertility and miscarriage should be comprehensive.

Author Biographies

S. V. Khmil, I. Horbachevsky Ternopil National Medical University, Ternopil, Ukraine

DM (Medicine), professor of the Department of Obstetrics and Gynecology No. 1, I. Horbachevsky Ternopil National Medical University

Yu. B. Pravak, I. Horbachevsky Ternopil National Medical University, Ternopil, Ukraine

is a postgraduate student of the Department of Obstetrics and Gynecology No. 1, I. Horbachevsky Ternopil National Medical University

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Published

2024-04-30

How to Cite

Khmil, S. V., & Pravak, Y. B. (2024). PATHOGENETIC INTERSECTIONS OF POLYCYSTIC OVARY SYNDROME AND METABOLIC SYNDROME IN WOMEN WITH INFERTILITY: (LITERATURE REVIEW). Bulletin of Social Hygiene and Health Protection Organization of Ukraine, (1), 95–100. https://doi.org/10.11603/1681-2786.2024.1.14631

Issue

No. 1 (2024)

Section

The review of the scientific literature

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