CLINICAL RESULTS IN WOMEN WITH INFERTILITY DUE TO PCOS AND CHRONIC ENDOMETRITIS IN ASSISTED REPRODUCTIVE TECHNOLOGY PROGRAMS
DOI:
https://doi.org/10.11603/1681-2786.2022.4.13687Keywords:
infertility, assisted reproductive technologies, in vitro fertilization, polycystic ovary syndrome, chronic endometritis, PRP therapy, induction of ovulation, pregravid therapyAbstract
Purpose: to analyze the effect of different treatment regimens on the clinical results of infertility treatment in women with PCOS and chronic endometritis in vitro fertilization protocols.
Materials and Methods. The study involved 140 women with endocrine infertility against the background of PCOS and chronic endometritis, who were divided into three treatment groups, depending on the cause of infertility and treatment approach, as well as 35 women with infertility due to male causes, who comprised the control group. The patients in this study were assessed for the effectiveness of infertility treatment according to the parameters of the IVF protocols.
Results. As a result of stimulation of superovulation in patients with infertility against the background of PCOS and chronic endometritis, in case of modified therapy scheme, the number of follicles (by 165.98 %), received oocytes (by 164.25 %), the number of MII`s are probably higher than in the comparison group (by 137.82 %), the number of MI (by 302.60 %), the number of GV (by 282.50 %) and the number of deg (by 295.00), as well as the number of fertilized cells of normal shape (by 2.30 times ), number of unfertilized oocytes (3.12 times), number of abnormally fertilized oocytes (1PN) (3.05 times), number of abnormally fertilized oocytes (3PN) (2.38 times), blastocyst yield ( by 1.94 times) and the number of high-class cells (by 2.17 times).
Conclusion. In patients with PCOS and chronic endometritis, the use of modified scheme therapy, which includes the f inositol and alpha-lipoic acid in pregravid pre-treatment, PRP-therapy of the uterine cavity and infusion of lipofundin on the day of embryo transfer, helps to improve the results of IVF protocols.
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