THE EFFECT OF BLOOD PRESSURE VARIABILITY ON THE COGNITIVE AND PSYCHO-EMOTIONAL SPHERES IN PATIENTS (PUBLIC SERVANTS) AFTER AN ISCHEMIC STROKE WITH MILD NEUROLOGICAL DEFICIT
DOI:
https://doi.org/10.11603/1681-2786.2021.4.12860Keywords:
blood pressure variability, ischemic stroke, cognitive disorders, psycho-emotional disordersAbstract
Purpose: to investigate the effect of blood pressure variability (BP) on the severity of manifestations of cognitive deficits and emotional and volitional disorders in patients after ischemic stroke.
Materials and Methods. The study included 90 patients aged 33 to 72 years: the 1st (main) group consisted of 30 patients who suffered an ischemic stroke (II) on the background of hypertension (H) with mild neurological deficits and returned to work; 2nd 30 patients with H for more than 5 years, 3rd group 30 patients without chronic diseases. The average age of patients was in the main group 57.6 7.0, in the first contr.– 57.5 7.5, in the second cont. – 44.4 7.9 years.
Research methods used: clinical, neuropsychological testing, statistical methods.
Results. The analysis of anthropometric data revealed that patients of the main and first control groups were overweight (BMI>25), while patients of the second control group (almost healthy) had a BMI slightly higher than the reference. Cognitive and psycho-emotional areas did not differ significantly in patients’ main and first control groups.
Conclusions. When studying the impact of BPV on the cognitive sphere and psycho-emotional state of patients after stroke with mild neurological deficit, it was found that the indicators of BPV were kept within acceptable values. When comparing the data of studies of patients of the main and I counter. groups with a group of relatively healthy patients (2 contr.gr.), inter-visit BP variability (SBP, DBP) was significantly lower in the latter (p<0.001, p=0.004).
References
Ostroumova, O.D., Guseva, T. F., Abakumov, U.E., & Batutina, A.M. (2013). Variabelnost sistolicheskogo i diastolicheskogo arterialnogo davleniya pri arterialnoy gipertenzii: klinicheskaya znachimost, vozmozhnyye patogeneticheskiye mekhanizmy [Variability of systolic and diastolic blood pressure in hypertension: clinical significance, possible pathogenetic mechanisms]. Kardiovaskulyarnaya terapiya i profilaktika – Cardiovascular Yherapy and Prevention, 2, 91-94 [in Russian].
Gorbunov, V.M. (2017). Sovremennyye predstavleniya o variabelnosti arterialnogo davleniya [Modern ideas about the variability of blood pressure]. Ratsionalnaya farmakoterapiya v kardiologii – Rational Pharmacotherapy in Cardiology, 8(6), 810-813 [in Russian].
Kovalenko, O.E. (2016). Otsinka variabelnosti sertsevoho rytmu pry vertebralno-bazylyarnykh rozladakh, povyazanykh iz tservikovertebrohennym faktorom [Assessment of heart rate variability in vertebrobasilar disorders associated with cervicovertebrogenic factor]. Medychnyy chasopys – Medical Journal, 3(53), 133-137 [in Ukrainian].
Nimtsovich, T.I., & Kravchenko, A.M. (2018). Variabelnist arterialnoho tysku: klinichne znachennya ta mozhlyvosti korektsiyi [Blood pressure variability: clinical significance and possibilities of correction]. Kardiologiya: ot nauki k praktike – Cardiology: From Science to Practice, 2 [in Ukrainian].
Ostroumova, O.D., Guseva, T.F., & Khvorostyanaya, I.V. (2014). Variabelnost arterialnogo davleniya – novaya mishen dlya profilaktiki insulta [Blood pressure variability is a new target for stroke prevention]. Pharmateka – Pharmac, 14(247), 39-44 [in Russian].
Guryanov, V.G., Lyakh, E.Yu., Pariy, V.D., Korotky, O.V., Chaly, O.V., & Chaly, K.O. (2018). Posibnyk z biostatystyky. Analiz rezultativ medychnykh doslidzhen u paketi EZR (R–statistics) [Handbook of Biostatistics. Analysis of the results of medical research in the package EZR (R – statistics)]. Kyiv: Vistka [in Ukrainian].
Sirenko, Yu.M. (2014). Medykamentozna profilaktyka insultu u khvorykh na arterialnu hipertenziyu [Drug prevention of stroke in patients with arterial hypertension]. Liky Ukrayiny – Medicines of Ukraine, 12, 7-12 [in Ukrainian].
Khomazyuk, T.A., & Krotova, V.Yu. (2019). Faktory ryzyku kohnityvnykh porushen pry arterialniy hipertenziyi [Risk factors for cognitive impairment in hypertension]. Ukrayinskyy medychnyy chasopys – Ukrainian Medical Journal, 2(2), 130 [in Ukrainian].
Lees, R., Fearon, P., Harrison, J.K., Broomfield N.M., & Quinn T.J. (2019). Cognitive and mood assessment in stroke research: focused review of contemporary studies. Stroke, 43, 1678-1680.
Kanda Y. (2013). Investigation of the freely available easy-to-use software ‘EZR’ for medical statistics. Bone Marrow Transplant, 48, 452-458. Retrieved from: https://www.nature.com/articles/bmt2012244.
Lloyd-Jones, D., Adams, R.J., & Brown, T.M. (2017). Heart disease and stroke statistics. 2010 update: report from the American Heart Association. Circulation, 121, 46-215.
Pendlebury, S.T. (2017). Dementia in patients hospitalized with stroke: rates, time course, and clinico-pathologic factors. Int. J. Stroke, 7(7), 570-581.
Mijajlovic, M.D., Pavlovic, A., Brainin, M., Heiss, W.-D., Quinn, TJ., Ihle-Hansen, H.B.,… Hermann, D.M. (2017). Post-stroke dementia - a comprehensive review. BMC Med., 15, 11. Retrieved from: https://bmcmedicine.biomedcentral.com/articles/10.1186/s12916-017-0779-7.
Rothwell, P.M., Howard, S.C., Dolan, E., O’Brien, E., Dobson, J.E., Dahlöf, B.,... Poulter, N.R. (2020). Prognostic significance visit-to-visit variability, maximum systolic blood pressure, and episodic hypertension. Lancet, 375(9718), 895-905. DOI 10.1016/S0140-6736(10)60308-X.
McKevitt, C., Fudge, N., & Redfern, J. (2019). Self-reported long term needs after stroke. Stroke, 42, 1398-1403.
Feigin, V.L., Lawes, C.M., Bennett, D.A., & Anderson, C.S. (2013). Stroke epidemiology: a review of population-based studies of incidence, prevalence, and case-fatality in the late 20th century. Lancet Neurol., 2, 43-53.
Strong, K., Mathers, C., & Bonita, R. (2007). Preventing stroke: saving lives around the world. Lancet Neurol., 6, 182-187.
Pollock, A., St. George, B., Fenton, M., & Firkins, L. (2013). Top ten research priorities relating to life after stroke. Lancet Neurol., 11, 209.
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