THE USE OF POLYDEOXYRIBONUCLEOTIDES IN THE COMPLEX TREATMENT OF PATIENTS WITH INJURIES OF THE MANDIBLE (LITERATURE REVIEW)
DOI:
https://doi.org/10.11603/2311-9624.2025.1.15450Keywords:
DNA, PDRN, adenosine A2 receptors, wound healing, polydeoxyribonucleotide, biomaterials, mandibular fracture, maxillofacial fixation, bone regeneration, vascularization and angiogenesis.Abstract
Materials and Methods. The search was carried out in PubMed, Web of Science, ProQuest, GoogleScholar, OpenThesis and national literature until 2024. Results. The total number of publications found that included keywords was 98. Among them, 21 papers were devoted to reconstructive surgery and traumatology in the maxillofacial area, 23 papers to the use of biomaterials to optimize the reparative process, 15 papers on revascularization and angiogenesis of bone defects, and 10 papers on the use of polydeoxyribonucleotide in the management of bone defects. The 36 articles that were most suitable for the keywords and context were selected for the article. Conclusions. Despite the fact that the mechanism of action of polydesoxyribonucleotide has been sufficiently studied, its effect on hard tissues and its use in traumatic injuries and bone defects is not well understood. The use of polydesoxyribonucleotide in the treatment of bone injuries and defects has potential and should be further investigated.
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