THE EFFECT OF AMARANTH OIL ON THE STATE OF CHANGES IN SOME FUNCTIONAL SYSTEMS OF THE BODY OF RATS IN THE SIMULATION OF PERIODONTITIS

Authors

DOI:

https://doi.org/10.11603/2311-9624.2024.4.15203

Keywords:

cperiodontitis, amaranth oil, blood, reactions of energy supply, exchange of proteins, calcium.

Abstract

The purpose of the study. Determination of the effect of internal administration of amaranth oil on the state of some functional systems in rats with a periodontitis model. Research materials and methods. The research was conducted on 82 white rats of the Wistar line of outbred breeding with a body weight of 180–200 g. Work with rats was carried out in accordance with the requirements of regulatory documents of the EU and Ukraine. The periodontitis model was reproduced by replacing drinking water with a 2% EDTA solution, to which warfarin was added in a dose of 10 mg/kg body weight after a day. The duration of the experiment is 60 days. Control points of the condition of the functional systems of rats 30 and 60 days after the start of administration of 2% EDTA solution. Amaranth oil was used from the 30th day of the experiment in a dose of 0.3 ml per rat. Amaranth oil was injected directly into the rat’s mouth. Scientific novelty. The conducted studies determined that the development of the periodontitis model is accompanied by changes in blood parameters characteristic of the development of non-gross inflammatory reactions and the absence of allergic reactions. On the side of metabolic processes, there was a deterioration of the energy supply of transmembrane transport and a weakening of the activity of protein synthesizing reactions, in addition, the catabolism of nitrogen-containing compounds increases and the activity of the nitric oxide cycle decreases. The removal of Ca+2 from the depot also increases when its use is reduced. Conclusions. Regular use of amaranth oil has a positive effect on the state of the body’s functional systems. On the part of the peripheral blood, there is a decrease in the indicators of the presence of inflammatory reactions and the preservation of the level of transport function of red blood. On the part of metabolism, there was a significant improvement in energy supply indicators, less activity, compared to uncorrected periodontitis of the POL/AOZ system, and an improvement in calcium metabolism.

References

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Published

2024-06-26

How to Cite

Shevchenko, S. R., Leonid, D. C., & Yakimenko, D. O. (2024). THE EFFECT OF AMARANTH OIL ON THE STATE OF CHANGES IN SOME FUNCTIONAL SYSTEMS OF THE BODY OF RATS IN THE SIMULATION OF PERIODONTITIS. CLINICAL DENTISTRY, (4), 60–65. https://doi.org/10.11603/2311-9624.2024.4.15203

Issue

Section

Experimental researches