Morphological features of pathological skin scaring under the conditions of diabetes mellitus in different ways of wound closure

Abstract

Summary. Diabetes mellitus (DM) is recognized worldwide as one of the most important non-communicable diseases, as well as one of the most serious health problems of the 21st century. The need to prevent the formation of pathological scarring of tissues after surgery, injuries, burns was and remains an urgent scientific and practical task. Therefore, the optimization of methods of wound healing and prevention of pathological scars on the background of diabetes is of considerable scientific interest for practical medicine and dentistry.

The aim of the study – to find out the features of pathological scarring in experimental diabetes and to establish the effectiveness of preventive use of skin glue.

Materials and Methods. Experimental studies were performed on 130 white outbred adult male rats weighing from 240 to 320 g. The animals were kept in the vivarium of I. Horbachevsky Ternopil National Medical University Ministry of Health of Ukraine, in accordance with sanitary and hygienic norms and requirements of GLP.

Results and Discussion. The results of biochemical studies obtained by us indicate an increase in the activity of free radical processes in the experimental wound process. However, different intensities of these reactions have been found in healthy and diabetic animals, in particular, with different methods of fixing wound edges.

Conclusions. The use of surgical glue to suture the edges of surgical wounds in animals with induced diabetes is characterized by less inflammatory response, faster epithelialization of the wound surface and the transformation of granulations into young connective tissue, as well as reducing scarring of the damaged area than using surgical sutures.