Age features of the reaction of the endocrine system in injured with traumatic fractures of the mandible

Abstract

Peculiarities of age-related changes in the concentration of cortisol, parathyroid hormone, thyroxine in the dynamics of victims with traumatic mandibular fractures have been studied. It was found that throughout the observation period, the concentration of all hormones differed from normal and had its own age characteristics. The greatest increase in the level of cortisol and parathyroid hormone was found in injured aged 20–29 years, and thyroxine – in patients aged 40–49 years.

Theaim of the study – to examine the dynamics of the concentration of blood hormones that affect the synthesis and mineralization of callus in the fracture area in the treatment of victims with traumatic open fractures of the mandible of different ages.

Materials and Methods. A study of the hormonal status of 38 victims with traumatic mandibular fractures 20–49 years on the 1st, 10th, 20th days of observation. To do this, the level of cortisol in the blood was determined using the test system FK 210 R (version 03.2002), parathyroid hormone – using the DSL ACTIVE I-PTH kit, thyroxine – using the test system FK 212 R (version 12.2001). Fracture treatment was performed using dental braces and standard medication.

Results and Discussion. Summarizing the results, it can be argued that thyroid hormones have a modeling effect on bone metabolism. Metabolic effects are explained by the synthesis and increase in the activity of many cellular enzymes, their effect on the permeability of cell and mitochondrial membranes, as well as the stimulation of metabolism in mitochondria. They control RNA synthesis in cell nuclei, regulate protein synthesis in ribosomes, have a permissive effect on genetically determined processes and the action of other hormones.

Conclusions. In patients with traumatic fractures of the mandible at all ages, an imbalance of hormones that affect the synthesis and mineralization of callus is established.