Modern principles and methods of drug treatment in cases of generalized periodontitis
(literature review)
DOI:
https://doi.org/10.11603/2311-9624.2020.4.11720Keywords:
generalized periodontitis, drug treatment, principles of treatment, drugsAbstract
Summary. Treatment of generalized periodontitis is based on the principles of the integrated approach, taking into account the individual characteristics of dental and somatic status, the prevalence of certain local and general periodontal factors in each clinical situation. Etiotropic treatment involves rational general and local antimicrobial therapy to eliminate periodontal pathogenic bacteria and block the inflammatory cascade with the production of proinflammatory cytokines, eicosanoids, matrix metalloproteinases, etc. Pathogenetic treatment is aimed at alleviating the leading links in the development of the disease. The prescription of nonsteroidal anti-inflammatory drugs, use of exogenous inhibitors of matrix metalloproteinases; immunocorrective therapy; cytokine therapy; use of antioxidants; appointment of drugs to stimulate the process of bone formation are justified. The correct direction of etiopathogenetic drug treatment is confirmed by numerous data from the literature on its high clinical efficacy. However, the development of differentiated approaches to the choice of drugs for general and local use depending on exo- and endoparodontopathogenic factors, that influence the pathogenesis of generalized periodontitis most, still remains relevant.
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