Morphological and microbiological substantiation of antibioticosorbent capacity of synthesized biopolymer microfibers
DOI:
https://doi.org/10.11603/2311-9624.2020.2.11400Keywords:
matrix materials, collagen, polycaprolactone, impregnation with antibiotics, cefazolin, lincomycinAbstract
Summary. Combinations of fibrous materials with therapeutic agents as a drug delivery system are currently studied. A new direction has appeared in reconstructive surgery – tissue engineering, which aims to restore biological functions, i.e. tissue regeneration, not only to replace it with synthetic material.
The aim of the study – to evaluate the antibiotic-sorbing ability of the three-dimensional non-woven matrices we created for reconstructing bone defects.
Materials and Methods. The study was conducted with using the samples of three-dimensional microfibrous non-woven matrix for the defects’ reconstruction of the bone tissue made of polycaprolactone according to the developed technique. Collagen fragments were used as control.
Results and Discussion. The evaluation of the preservation of antibiotics in samples of matrix materials was performed on the 1st, 3rd, 5th, 7th, 14th, 18th and 21st day of the experiment. The obtained experimental data indicate that both drugs (cefazolin and lincomycin) were stored in significant quantities both in the collagen and polycaprolactone matrix, throughout the entire observation period.
Conclusions. The developed matrix materials are a means of a one-time local delivery of the drug to tissues in the damaged zone. This is especially relevant in surgical dentistry, since even strict adherence to aseptic rules cannot ensure that individual microbial cells from the surface of the oral mucosa and saliva get into the surgery area.
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