Parameters of bone metabolism in patients with generalized parodontitis accompanied with chronic rheumatic heart disease
DOI:
https://doi.org/10.11603/2311-9624.2020.1.11225Keywords:
calcium, phosphorus, magnesium, oxyproline, alkaline phosphatase, chronic rheumatic heart disease, generalized periodontitisAbstract
The article presents the results of the study of the state of calcium-phosphorus-magnesium metabolism and bone metabolism in patients with periodontal tissue diseases accompanied with chronic rheumatic heart disease and persons in the control group. The results of the study indicate the violation of regulatory mechanisms of bone remodeling in patients with chronic rheumatic heart disease.
The aim of the study – to learn the indices of calcium-phosphorus-magnesium metabolism and bone metabolism in patients with periodontal tissue diseases with concomitant chronic rheumatic heart disease.
Materials and Methods. Studies of calcium-phosphorus metabolism, oxyproline and alkaline phosphatase in serum of 96 patients with chronic rheumatic heart disease (main group) and 34 practically healthy persons (control group) were carried out. Observation groups included patients with generalized periodontitis of grade I, II and III severity from 35 to 54 years of age.
Results and Discussion. Analyzing the results of calcium-phosphorus-magnesium metabolism in the serum of patients with СRHD it is possible to state that dystrophic processes in the bone tissue of the alveolar process with generalized periodontitis occur which are accompanied with significant changes in calcium-phosphorus homeostasis. Changes in oxyprolin levels and decreased alkaline phosphatase activity in patients with СRHD may indicate a weakening of bone remodeling processes, which may be a prerequisite for significant bone loss of the periodontal bone.
Conclusions. The imbalance of bone metabolism parameters in patients with СRHD confirms the assumption of damage of the bone system at the stage of tissue metabolism, and thus may be the cause of progressive osteoporosis and rapid progression of generalized periodontitis.
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