Clinical efficacy of preventive and curative interventions in chronic catarrhal gingivitis

A. V. Avdeev, Y. K. Zmarko, A. B. Boykiv, R. A. Drevnitska


Treatment of inflammatory periodontal diseases remains an urgent problem of dentistry as a result of frequent recurrence, inflammation in alveolar bone tissue with periodontal tissue destruction, so developing pathogenetic effects in treating the chronic catarrhal gingivitis is timely.

The aim of the study – to conduct the pathogenetic treatment of gingivitis and the assessment of its effectiveness.

Materials and Methods. 67 children aged 16–18 years, suffering from chronic catarrhal gingivitis, were taken under clinical supervision and divided into groups: the main (35 children) and the comparative (32 children). All children underwent conventional therapy in accordance with the protocols for the provision of medical care – basic therapy. In the main group, for a month, pathogenetic agents were used: an anti-inflammatory gel with neovitin, hygiene products were recommended. In the comparative group, 3 % hydrogen peroxide solution was used for local therapy, for rinsing of the mouth (during the first week of treatment) – Rotokan, a therapeutic and prophylactic toothpaste.

Examination and control examinations were carried out with the hygienic state of the mouth determined by the hygienic index of Green-Vermillion (ОНІ-S), prevalence and intensity of the inflammatory process in the gums with the help of the Schiller-Pisarev test and the PMA index, oral fluid index (content of total glutathione, oxidized and reduced glutathione, glutathione redox index).

Results and Discussion. Immediately after the treatment in the main group, the decrease in the PMA index was 2.6 times; GI – in 1.4 times, ONI-S – in 1.7 times. A reduction in the treatment period of adolescents in the application of the proposed therapeutic scheme is established. The content of total glutathione in the main group was significantly higher (p <0.05) than that of the comparator group before treatment (by 12.2 %) and comparing the indicator in 0.5 years (by 8.8 %). In this observation period, the difference between the content of oxidized and reduced glutathione in persons of the main and comparative groups was also significant – 1.8 times and 1.2 times, respectively. In addition, the redox index of glutathione in the main group increased and even exceeded the control group, although there was no significant difference.

Conclusion. The use of the proposed therapy with gel with neovitin contributed to the best results of treatment: reducing the degree of inflammation of the gums, the number of visits to the doctor, improving the indices of nonspecific protection in the oral fluid and, to a greater extent, six months after the treatment.


16–18 year–old teens; chronic catarrhal gingivitis; nonspecific protection; treatment.


WHO releases new report on global problem of oral diseases // World Health Organization, 2009. URL:

Ulitovskiy, S.B. (2006) Gigiyena polosti rta v parodontologii [Oral hygiene in periodontics]. Moscow: Meditsinskaya kniga [in Russia].

Chereda, V.V., Petrushanko, T.O., & Loban, H.A. (2011). Skryninhova otsinka kolonizatsiinoi rezystentnosti slyzovoi obolonky porozhnyny rota [Screening evaluation of colonization resistance of the mucous membrane of the oral cavity]. Visnyk stomatolohii – Journal of Stomatology, (2), 33-35 [in Ukrainian].

Avdieiev, O.V. (2013). Kliniko-patohenetychni osnovy rozvytku ta likuvannia zapalnykh ta dystrofichno-zapalnykh zakhvoriuvan parodonta pry riznii reaktyvnosti orhanizmu [Clinical and pathogenetic bases of development and treatment of inflammatory and dystrophic-inflammatory periodontal diseases at different reactivity of the organism]. Doctor’s Extended abstract. Lviv, 36 p. [in Ukrainian].

Voskresenskiy, O.N. & Tkachenko, Ye.K. (1991). Rol perekisnogo okisleniya lipidov v patogeneze parodontita [Role of lipid peroxidation in the pathogenesis of periodontitis]. Stomatologiya – Stomatology, (4), 5-10 [in Russian].

Avdieiev, O.V., Zmarko, Yu.K., Boikiv, A.B., & Drevnitska, R.O. (2017). Vplyv likuvalno-profilaktychnykh zakhodiv na pokaznyky rotovoi ridyny ta klinichnyi stan tkanyn parodonta u ditei 6-7 rokiv, khvorykh na hinhivit [Influence of medical and preventive measures on indicators of oral liquid and clinical condition of periodontal tissues in 6-7 year-old children, patients with gingivitis]. Klinichna stomatolohiia – Clinical Dentistry, (1), 32-38 [in Ukrainian].

Avdieiev, O.V., Zmarko, Yu.K., Boikiv, A.B., & Drevnitska, R.O. (2017). Dynamika pokaznykiv rotovoi ridyny ta klinichnoho stanu tkanyn parodonta u ditei z hinhivitom pid vplyvom likuvalno-profilaktychnykh zakhodiv [Dynamics of indicators of oral liquid and clinical state of periodontal tissues in children with gingivitis under the influence of treatment and preventive measures]. Visnyk naukovykh doslidzhen – Journal of Scientific Researches, (1), 102-105 [in Ukrainian].

Khomenko, L.A., Chaykovskiy, Yu.B. Savichuk, A.V., & Savichuk, A.V. (2007). Terapevticheskaya stomatologiya detskogo vozrasta [Therapeutic dentistry of childhood]. Kyiv: Knyha plius [in Ukrainian].

Zabolotnyi, T.D., Borysenko, A.V., & Pupin, T.I. (2013). Zapalni zakhvoriuvannia parodonta [Inflammatory periodontal disease]. Lviv: HalDent [in Ukrainian].

Anderson, M.E. (1985). Determination of glutathione and glutathione disulfide in biological samples. Meth. Enzymol., 113, 548-555.

Griffith, O.W. (1980). Determination of glutathione and glutathione disulfide using glutathione reductase and 2-vinylpyridine. Anal. Biochem., 106 (1), 207-212.



  • There are currently no refbacks.