Investigation of the dynamics of the immune status indicators in children with rampant caries on the background of gastrointestinal tract diseases in various terms of treatment

V. I. Rozhko


The level of immunoglobulins and lysozyme in the oral fluid deviates from the norm at presence of the diseases of the gastrointestinal tract (GI), which is likely to be a trigger in the development of rampant caries in children. A detailed study of this aspect has made it possible to directly influence the inhibition of the pathological process.

The aim of the study – to evaluate the effectiveness of the use of a complex of therapeutic and prophylactic measures aimed at increasing the resistance of the oral cavity in children with rampant caries on the background of diseases of the gastrointestinal tract in 12–14 days and 6 months after treatment; compare the data with these before treatment.

Materials and Methods. The article presents the results of the study of the dynamics of immunological parameters in children with rampant caries on the background of diseases of the gastrointestinal tract. The increase of the indexes of immunoglobulins A, G, secretory immunoglobulin A, lysozyme in the oral liquid of the children of the main, comparative and control groups was determined by the method of radial immunodiffusion in Mancini agar and agar diffusion method containing 0.05 % biomass powder Micrococcus lysodeikticus.

Results and Discussion. As a result of the proposed treatment and prophylactic complex, we managed to achieve a significant improvement in the immunological status of oral fluid in children with rampant caries on the background of GI tract diseases. Thus, after treatment (12–14 days), the content of IgA in the oral liquid of the children of the main group increased by 80.0 % higher in relation to the data before treatment. At the same time, in children of the main group, the decrease in the IgG concentration, which was lower than the data before treatment, was studied at 26.32 %. At 12–14 days after treatment in children with multiple caries, against the background of gastrointestinal lesions of the main group, an increase in sIgA and lysozyme was observed, which was 39.13 % and 23.85 % higher, respectively, for the data before treatment.

Conclusions. The complex of therapeutic and prophylactic measures introduced and implemented in clinical practice causes a pronounced caries prophylactic effect and improves the state of hygiene, increases the acidity of the enamel and mineralizing properties of the oral liquid, normalizes microbiocenosis and immunological status, which in general optimizes the processes of remineralization.


immunological status; caries; gastrointestinal tract.


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