Modern views for application of platelet rich plasma In the dentistry

  • Yu. Yu. Lysokon I. Horbachevsky Ternopil National Medical University
Keywords: plasma-enriched platelets, growth factor, regeneration of bone tissue


Summary. It is known that the use of own blood for the treatment of various diseases began in ancient times, since the birth of medicine. Currently, plasma-enriched platelets are one of the successful areas of tissue engineering and cell therapy in medicine. In the evolution of terminology, there are many different variants of the names of plasma-enriched platelets as the final product. In clinical practice it is believed that the stimulating effect of plasma-enriched platelets is possible at a concentration of platelets in it not less than 1 000 000/μl. When tissue damage occurs, platelets play a leading role in the healing and regeneration of tissues due to the release of growth factors. Based on the information of the literature, the high potential of platelet-rich plasma therapy for bone tissue regeneration is shown. So far, no proper clinical studies have been performed on the efficacy of plasma-enriched platelet therapy that would meet all current criteria. Plate-enriched platelet therapy is a promising industry in medicine and needs further research as a new effective and safe method in medical practice.

Therefore, the use of growth factors is particularly interesting in cases where the effectiveness of bone materials and osteointegration are quite questionable (for example, with severe osteoporosis or scar tissue changes). Further studies are needed to determine the optimal concentration of various growth factors and to identify the unknown growth factors that may exist in the plasma-enriched platelets. Such studies could reveal additional benefits of using this treatment for wound healing and bone regeneration.

The aim of the study – analysis of scientific literature on the effectiveness of the use of autologous plasma enriched platelets to optimize the treatment of stomatological diseases.

Materials and Methods. The study used bibliosemantic and analytical methods of research.

Results and Discussion. During the study, the review and analysis of the latest data from domestic and foreign scientific and medical literature on modern aspects of the use of autologous, platelet-enriched plasma for the treatment of dental diseases, review of the main methods for its manufacture, advantages and disadvantages of its application were conducted.

Conclusions. Based on the analysis of available literature on the topic of the study, we concluded that the continued relevance of improved approaches to the treatment of major dental diseases enriched with platelets by plasma. Therefore, on the basis of acquaintance with the data of the literature, it can be concluded that the issue of modern use in dentistry autologous platelet-enriched plasma remains relevant and needs further study.

Author Biography

Yu. Yu. Lysokon , I. Horbachevsky Ternopil National Medical University

Lysokon Yuliia Yuriivna

Postgraduate Student

at the Department of Therapeutic Dentistry

I. Horbachevsky Ternopil National Medical University, Ternopil, Ukraine


Tayapongsak, P., O'Brian, D.A., Monteiro, C.B., & Arceo-Diaz, L.Y. (1994). Autologous fibrin adhesive in mandibular reconstruction with particulate cancellous bone and marrow. J. Oral Maxillofac. Surg., 52, 161-165.

Marx, R.E., Carlson, E.R., Eichstaedt, R.M., Schimmele, S.R., Strauss, J.E., & Georgeff, K.R. (1998). Platelet-rich plasma. Growth factor enhancement for bone grafts. J. Oral Surg. Oral Med. Oral Pathol. Oral Radial. Endod., 85, 638-646.

Zhang, Y., Zeng, B., & Zhang, C. (2014). Effects of platelet-rich plasma on proliferation and osteogenetic activity of marrow mesenchymal stem cells in vitro. J. Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 19, 109-113.

Mauro, S., Orlando, L., Panzoni, R., & Orlando, P.F. (2003). Platelet gel biotechnology applied to regenerative surgery of intrabony defects in patients with refractory generalized aggressive peridontitis. Case report. Minerva Stomatol., 52, 401-412.

de Obarrio, J.J., Araúz-Dutari, J.I., Chamberlain, T.M., & Croston, A. (2010). The use of autologous growth factors in periodontal surgical therapy: platelet gel biotechnology – case reports. J. Periodontics Restorative Dent., 20, 486-489.

Choi, B.H., Zhu, S.J., Kim, B.Y., Huh, J.Y., Lee, S.H., & Jung, J.H. (2015). Effect of platelet-rich plasma (PRP) concentration on the viability and proliferation of alveolar bone cells: an in vitro study. Int. J. Oral Maxillofac. Surg., 34, 420-424.

De Obarrio, J.J., Araúz-Dutari, J.I., Chamberlain, J.M., & Croston, A. (2000). The use of autologous growth factors in periodontal surgical therapy: platelet gel biotechnology. Case reports. Int. J. Periodontics Restorative Dent., 20 (5), 486-497.

Altmeppen, J., Hansen, E., Bonnländer, G.L., Horch, R.E., & Jeschke, M.G. (2014). Composition and characteristics of an autologous thrombocyte gel. J. Surg. Res., 117, 202-207.

Landesberg, R., Burke, A., Pinsky, D., Katz, R., Vo, J., Eisig, S.B., & Lu, H.H. (2005). Activation of platelet-rich plasma using thrombin receptor agonist peptide. J. Oral Maxillofac. Surg., 63, (4), 529-535.

Simon, D., Manuel, S., Geetha, V., Naik, B.R. (2014). Potential for osseous regeneration of platelet-rich plasma – a comparative study in mandibular third molar sockets. Indian J. Dent. Res., 15 (4), 133-136.

Sammartino, G., Tia, M., Marenzi, G., di Lauro, A.E., D'Agostino, E., & Claudio, P.P. (2015). Use of autologous platelet-rich plasma (PRP) in periodontal defect treatment after extraction of impacted mandibular third molars. J. Oral Maxillofac. Surg., 63 (6), 766-770.

Kawase, T., Okuda, K., Saito, Y., & Yoshie, H. (2005). In vitro evidence that the biological effects of platelet-rich plasma on periodontal ligament cells is not mediated solely by constituent transforming-growth factor-beta or platelet-derived growth factor. J. Periodontol., 76 (5), 760-767.

Cacciafesta, V., Dalstra, M., Bosch, C., Melsen, B., & Andreassen, T.T. (2001). Growth hormone treatment promotes guided bone regeneration in rat calvarial defects. Eur. J. Orthod., 23 (6), 733-740.

Wiltfang, J., Kloss, F.R., Kessler, P., Nkenke, E., Schultze-Mosgau, S., Zimmermann, R., & Schlegel, K.A. (2004). Effects of platelet-rich plasma on bone healing in combination with autogenous bone and bone substitutes in critical-size defects. An animal experiment. Clin. Oral Impl. Res., 15 (2), 187-193.

Anitua, E., Sánchez, M., Nurden, A., Nurden, P., Orive, G., & Andía, I. (2006). New insights into and novel applications for platelet-rich fibrin therapies. Trends in Biotechnol., 24 (5), 227-234.

Steed, D.L. (1997). The role of growth factors in wound healing. Surg Clin North Am., 77 (3), 575-586.

Marx R.E. (2001). Platelet-rich plasma (PRP): what is PRP and what is not PRP? Implant. Dent.,10 (4), 225-228.

Zhu, S.J., Choi, B.H., Jung, J.H., Lee, S.H., Huh, J.Y., You, T.M., ..., & Li, J. (2006). A comparative histologic analysis of tissue-engineered bone using platelet-rich plasma and platelet-enriched fibrin glue. Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod.,102 (2), 175-179.

Lindeboom, J.A., Mathura, K.R., Aartman, I.H., Kroon, F.H., Milstein, D.M., & Ince, C. (2007). Influence of the application of platelet enriched plasma in oral mucosal wound healing. Clin. Oral Impl. Res.,18 (1), 133-139.

Fuerst, G., Gruber, R., Tangl, S., Sanroman, F., & Watzek, G. (2004). Effects of fibrin sealant protein concentrate with and without platelet-released growth factors on bony healing of cortical mandibular defects. An experimental study in minipigs. Clin. Oral Implants Res., 15 (3), 301-307.

Zechner, W., Tangl, S., Tepper, G., Fürst, G., Bernhart, T., Haas, R., …, & Watzek, G. (2003). Influence of platelet-rich plasma on osseous healing of dental implants: A histologic and histomorphometric study in minipigs. Int. J. Oral Maxillofac Implants., 18 (1), 15-22.

How to Cite
Lysokon , Y. Y. (2019). Modern views for application of platelet rich plasma In the dentistry . Clinical Dentistry, (3), 40-45.
Surgical stomatology