Frequency of pleomorphic adenomas of salivary glands and their histological types according to archival analysis of medical records of O.O. Bohomolets National Medical University in the period of 2014–2018
Pleomorphic adenoma remains the most prevalent tumor among benign neoplasms of the salivary glands of 61 to 90 %. The clinical course of the tumor has a typical, weakly symptomatic, which complicates the establishment of a previous clinical diagnosis at the pre-hospital stage. The definitive diagnosis of "pleomorphic adenoma" is established on the basis of a pathohistological study. Morphological methods not only indicate the type of tumor – benign or malignant, but also determine its origin (phenotype of the tumor).
The aim of the study – to learn the frequency of pleomorphic adenomas of the salivary glands and their histological types according to archival analysis of the diseases history of O. O. Bohomolets National Medical University in the period of 2014–2018.
Materials and Methods. The material of the survey was the archival histories of 133 patients with pleomorphic adenomas of the salivary glands that were treated at the Kyiv City Clinical Hospital No. 12 at the clinical base of O. O. Bohomolets National Medical University in the period of 2014–2018. The average age of patients was (48±11.3). All patients underwent typical surgical interventions – excisional biopsy, partial, subtotal, total parotidectomy. Bioptats of the tumours were studied pathohistologically.
Results and Discussion. The most of "pleomorphic adenomas" were in parotid salivary glands – 110 (82.7 %) patients. Among the histological types of pleomorphic adenomas, mesenchymal was observed – 91 (68.42 %) patients, with a dominant of epithelial component – 30 (22.55 %), a classic (combined) variant (the same number of mesenchymal and epithelial components) – 11 (8.27 %), and with the domination of the myoepithelial component 1 (0.75 %).
Conclusions. The largest number of pleomorphic adenomas of the salivary glands was located in the parotid salivary glands – 110 (82.7 %). Among the histological types of pleomorphic adenomas, mesenchymal and epithelial types were prevalent – 91 (68.42 %) and 30 (22.55 %) patients. Women and men were dominated by mesenchymal and epithelial types of pleomorphic adenoma – 64 (71.11 %) and 20 (22.22 %), and 27 (62.79 %) and 10 (23.25 %), respectively. In this case, only for epithelial type of pleomorphic adenomas, the distribution by age had significant differences – for women, the average age was (39.87±9.74) years, for men – (48.5±11.66) years.
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