CYTOLOGICAL STUDY OF DIFFERENT THYROID LESIONS AND ITS CORRELATION WITH THYROID FUNCTION TEST
DOI:
https://doi.org/10.61751/ijmmr/2.2023.51Keywords:
fine needle aspiration cytology, Bethesda system, thyroid, cytologyhistopathologyAbstract
The research relevance of the combined use of fine needle aspiration cytology, sonography, and thyroid function tests is determined by accurate diagnostics of thyroid enlargement in both adults and children. The study aimed to analyse thyroid lesions through cytological analysis and their correlation with thyroid function test results. This cross-sectional study enrolled 100 patients with suspected thyroid disorders and nodules. Comprehensive assessments included clinic demographics, fine needle aspiration cytology procedures, and thyroid hormone profiles. Based on the Bethesda system, cytological diagnoses were correlated with thyroid function test results using the chemiluminescent microparticle immunoassay method. Non-tumour thyroid lesions were found to be the most common (95%), with colloidal goitre being the most common. Neoplastic cases mainly included papillary and follicular carcinoma. Most thyroid lesions occurred among the 21-30 age group, non-neoplastic cases were more frequent among the 10-20 age group, and neoplastic cases were more common in those aged 21-40. All patients had neck swelling. Most cases were euthyroid (76%), predominantly classified as Category 2. A strong correlation between cytological diagnoses and thyroid hormone levels (p=0.04) was observed. Fine needle aspiration cytology demonstrated good sensitivity (80%) and high specificity (98.46%), with an 80% positive predictive value and 98.46% negative predictive value, resulting in a diagnostic accuracy of 97.14%. The study highlights the valuable role of fine needle aspiration cytology, when coupled with thyroid function tests, in effectively guiding the management of patients with thyroid lesions, owing to its impressive accuracy, sensitivity, and specificity
Received: 10.08.2023 | Revised: 31.10.2023 | Accepted: 28.11.2023
References
McPherson RA, Pincus MR. Henry's clinical diagnosis and management by laboratory methods [Internet]. 23rd ed. Elsevier Health Sciences; 2017 [cited 2024 Feb 22]. 1700 p. Available from: https://books.google.com.ua/books/about/Henry_s_Clinical_Diagnosis_and_Managemen.html?id=xAzhCwAAQBAJ&redir_esc=y
Panato C, Vaccarella S, Dal Maso L, Basu P, Franceschi S, Serraino D, et al. Thyroid cancer incidence in India between 2006 and 2014 and impact of overdiagnosis. J Clin Endocrinol Metab. 2020;105(8):2507–14. DOI: 10.1210/clinem/dgaa192
Gore RW, Pandey R, Gupta DO. Incidence of thyroid disorders in central India: Retrospective Analysis at rural tertiary care hospital. Galore Int J Health Sci Res. 2019;4(4):76–80.
Can AS, Rehman A. Goitre [Internet]. Treasure Island: StatPearls Publishing; 2023 [cited 2024 Feb 22]. Available from: https://www.ncbi.nlm.nih.gov/books/NBK562161/
Hatch-McChesney A, Lieberman HR. Iodine and iodine deficiency: A comprehensive review of a re-emerging issue. Nutrients. 2022;14(17):e3474. DOI: 10.3390/nu14173474
Lee K, Anastasopoulou C, Chandran C, Cassaro S. Thyroid Cancer [Internet]. Treasure Island: StatPearls Publishing; 2023 [cited 2024 Feb 22]. Available from: https://www.ncbi.nlm.nih.gov/books/NBK459299/
Jamaiyar A, Yogesh K. How accurate is fine-needle aspiration cytology (FNAC) for thyroid lesion: A correlation of FNAC with histopathology. J Family Med Prim Care. 2023;12(1):15–20. DOI: 10.4103/jfmpc.jfmpc_1413_21
Petranović Ovčariček P, Verburg FA, Hoffmann M, Iakovou I, Mihailovic J, Vrachimis A, et al. Higher thyroid hormone levels and cancer. Eur J Nucl Med Mol Imaging. 2021;48(3):808–21. DOI: 10.1007/s00259-020-05018-z
Jain V, Agrawal V, Kalra R, Tripathi SK. Study of cytomorphological features of thyroid lesions and its correlation with thyroid function tests. Med Innovatica. 2021;10(2):55–59.
Poonam P. Diagnostic utility of FNAC in thyroid lesions and their histological correlation – A case study. IAIM. 2018;5(9):7–13.
Yazdaan HE, Jaya F, Sanjna F, Junaid M, Rasool S, Baig A, et al. Advances in thyroid function tests: Precision diagnostics and clinical implications. Cureus. 2023;15(11):e48961. DOI: 10.7759/cureus.48961
Mishra SKC, Kar SS, Behera DDB. Clinico-cytomorphological features and thyroid function tests of different thyroid lesions – A hospital-based cross-sectional study. Nat J Physiol Pharm Pharmacol. 2023;13(3):616–19. DOI: 10.5455/njppp.2023.13.01037202325012023
Begum Z, Reddy LG, Patil A. Bethesda reporting of thyroid FNACS with T3, T4, TSH correlation in a medical college of North Karnataka. IP J Diagn Pathol Oncol. 2020;5(4):405–9. DOI: 10.18231/j.jdpo.2020.078
The World Medical Association. Declaration of Helsinki: Ethical Principles for Medical Research Involving Human Subjects [Internet]. Available from: https://www.wma.net/what-we-do/medical-ethics/declaration-of-helsinki/
Thakor T, Daveshwar MR, Shah HS. Cytomorphological study of thyroid lesions using the bethesda system for reporting thyroid cytology and its correlation with Thyroid Function Test. J Evol Med Dent Sci. 2020;9(12):949–52. DOI: 10.14260/jemds/2020/204
Bhadouria DS, Raghuwanshi S, Saxena A. Cyto-histopathological correlation of thyroid lesions. Int J Med Biomed Stud. 2021;5(1):175–78. DOI: 10.32553/ijmbs.v5i1.1664
Asmelash D, Tesfa K, Biadgo B. Thyroid dysfunction and cytological patterns among patients requested for thyroid function test in an endemic goiter area of Gondar, North West Ethiopia. Int J Endocrinol. 2019; 2019:e9106767. DOI: 10.1155/2019/9106767
Patel CB, Vaishnav M, Garg S. Cytological evaluation of thyroid lesions and its correlation with thyroid function tests-in the era of the Bethesda system for reporting thyroid cytology. Eur J Mol Clin Med. 2022;9(6):2248–54.
Ranabhat S, Parajuli B, Poudel S, Pun G. Evaluation of different thyroid lesions with fine needle aspiration cytology and thyroid function tests. J Gandaki Med Coll Nepal. 2018;11(1):17–22. DOI: 10.3126/jgmcn.v11i1.20789
Haque MN, Sakik MA, Bhuiyan MAR, Akhter MF, Khan SR, Sarker MZ, Hossain MA. Correlation between FNAC and histopathology in the diagnosis of thyroid lesions. Bangladesh J Otorhinolaryngol. 2021;27(1):81–85. DOI: 10.3329/bjo.v27i1.53211
Syed M, Akhtar N, Hameed M, Mushtaq S, Loya A, Hassan U, Hussain M. The cytological and histopathological correlation of thyroid lesions. J Pak Med Assoc. 2022;72(2):300–4. DOI: 10.47391/JPMA.2224
Nandedkar SS, Dixit M, Malukani K, Varma AV, Gambhir S. Evaluation of thyroid lesions by fine-needle aspiration cytology according to Bethesda system and its histopathological correlation. Int J Appl Basic Med Res. 2018;8(2):76–82. DOI: 10.4103/ijabmr.IJABMR_169_17
Jeelani T, Rafiq D, Nazir W-u, Shafi Y, Bashir N, Charak A, et al. Histopathological and cytological correlation of thyroid nodules with emphasis on Bethesda system for reporting thyroid cytology: A 7 year study. Int J Contemp Med Res. 2018;5(1):28–31.
Yildirim Simsir I, Cetinkalp S, Kabalak T. Review of factors contributing to nodular goiter and thyroid carcinoma. Med Princ Pract. 2020;29(1):1–5. DOI: 10.1159/000503575
Kaur S, Kumar N, Singh H. Histopathological spectrum of thyroid lesions and its correlation with biochemical and radiological findings – study 100 cases. Asian J Pharm Clin Res. 2023;16(9):73–75. DOI: 10.22159/ajpcr.2023v16i9.47789
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