ENDOGENOUS INTOXICATION IN ANIMALS OF DIFFERENT AGE GROUPS IN CASE OF POLYTRAUMA
Background. Associated injury is a worldwide social and economic problem. Age related aspects of endogenous intoxication are not studied comprehensively. Annually, from 44 000 to 65 000 citizens die because of traumatic injuries. As a result, this number increased by 32.6% for the last 10 years. The detoxification system, as a component of the functional systems of the organism, experiences significant changes in case of polytrauma.
Objective. The study was aimed to discover pathogenetic peculiarities of the multiple trauma in age aspect in different disease periods and to explore the level of endogenous intoxication in this condition.
Methods. The experiments were performed on 72 white male rats aged 3, 6 and 12 months, which underwent simulation of severe skeletal trauma and examination of the contents of middle mass molecules and endogenous intoxication index (markers of endogenous intoxication) in 1, 4 and 24 hours after the associated injury.
Results. The most significant increase of the middle mass molecules was fixed in 24 hours after modeling of severe skeletal injuries in all groups of animals, especially it was the most pronounced in 12-month-old animals. The erythrocyte intoxication index reached the highest level in 4 hours after the injury, its increase was most significant in sexually mature adult animals.
Conclusion. A significant increasing of endogenous intoxication markers in 12-month-old rats, if compared to 3- and 6-month-old animals, can be caused by the decrease in compensatory protection mechanisms.
Asehnoune K, Еdouard A. Inflammatory response and polytrauma: an update. Reanimation 2006; 15: 568–575.
Balogh Z, Varga E, Tomka J, et al. The New Injury Severity Score Is a Better Predictor of Extended Hospitalization and Intensive Care Unit Admission Than the Injury Severity Score in Patients With Multiple Orthopaedic Injuries. J Orth Trauma 2003; 17: 508–512.
Brenneman FD, Boulonger BR, McLellan BA, et al. Measuring injury severity: time for a change? J Trauma 1998; 44: 580–582.
Dimar JR, Carreon LY, Riina J, et al. Early versus late stabilization of the spine in the polytrauma patient. Spine 2010; 35: 187–192.
Hildebrand F, Giannoudis P, Kretteck C, Pape H. Damage control: extremities. Injury 2004; 35: 678–689.
Huber-Lang M, Wiegner R, Lamp L, Rolf E. Brenner Mesenchymal Stem Cells after Polytrauma: Actor and Target Stem. Cells International 2016; 10.
Pomeranz, JL, Shaw LR, Yu NS, Moorhouse MD. Polytrauma and life care planning: Managing the complex interaction of multiple injuries. Work 2008; 31(3): 319–326.
Andreichyn MA, Bekh MD, Demyanenko VV. Method of diagnosis of endogenous intoxication of organism: methodical recommendations 1998: 10– 13. (In Ukrainian).
Sekela TIa, Hudyma AA. Patent for the Utility Model 30028 Ukraine IPC 2006 G 09B 23/00. Modeling method of polytrauma. Ternopil Medical University. U 2007 10471; Stated. 21.09.2007; Published.11.02.08; Biul. 3: 4. (In Ukrainian).
Togaybaiev AA, Kurguzkin AV, Rikun IV, Karibzhanova RM. Method of diagnosis of endogenous intoxication. Lab. Work 1988; 9: 22–24. (In Russian).
Valdmol BM, Volchehorskyi YV, Puzhevskyi AS, et al. Middle molecular peptides of blood as endogenous regulators of lipids peroxidation in normal and thermal burns. Medical chemistry questions 1991; 37 (1): 23–26. (In Russian).
Erokhyn YA, Havrylyn SV, Nemchenko NS. Endotoxicosis with severe concomitant injury. Surgery journal2001; 160 (5): 120–124. (In Russian).
Kyshkun AA, Kudynova AS, Ofytova AD, Myshuryna RB. Value of average molecules in appreciation of the endogenous intoxication level Militarymedical journal 1990; 2: 41–44. (In Russian).
Erokhyn YA, Havrylyn SV, Nemchenko NS. Endotoxicosis with severe concomitant injury. Surgery journal2001; 160 (5): 120–124. (In Russian). 14. Pidruchna SR, Vasylyshyn N A, Kulyanda OO, Kulyanda IS. Corrective effect of xenodermoplasticson the indexes of endogenous intoxication in severe injury. Medical chemistry 2011; 13 (1) 58–62. (In Ukrainian). 15. Kulyanda OO, Pidruchna SR, Kulyanda IS, Zakharchuk UM, Ostrivka OI. The dynamics of endogenous intoxication in severe injury. Pain. Anesthesia and intensive care 2010; 2: 54–58. (In Ukrainian).
Authors who sent their manuscript to International Journal of Medicine and Medical Research agree to the following terms:
1. Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License CC-BY-NC that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
2. Authors able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
3. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).