RESEARCH IN SENSITIVITY TO ANTIBIOTICS, ANTISEPTICS IN PSEUDOMONAS AERUGINOSA STRAINS ISOLATED FROM PATIENTS WITH INFECTIOUS COMPLICATIONS

  • O. A. Nazarchuk Vinnytsia National Pirogov Memorial Medical University
  • D. V. Paliy Vinnytsia National Pirogov Memorial Medical University
  • N. I. Osadchuk Vinnytsia National Pirogov Memorial Medical University
Keywords: antibiotics, antiseptics, infectious complications, resistance.

Abstract

Background. Infections caused by Pseudomonas are one of the topical issues of medicine.

Objective. The aim of the research was to study sensityvity to antibiotics, antiseptics of P. aeruginosa clinical strains that cause infectious complications in patients with burns.

Methods. Microbiological study of biological material, received from 435 patients with burns of the 3rd-4th stages (2011-2015 years). In early terms of burn disease 127 clinical strains of P. aeruginosa were isolated from patients. Standard methods were used to identify clinical isolates of P. aeruginosa by their morphological, tinctirial, culture and biochemical properties. The research of antimicrobial action of antiseptics, antibiotics against Pseudomonas were carried out by means of standard methods according to the Directive of the Ministry of Health of Ukraine (No. 167 from 05.04.2007 р.) and guidelines of National Committee of Clinical and Laboratory Study (NCCLS, 2002).

Results. It was established that P. aeruginosa caused infectious complications in 23.9% of patients among other pathogens. Clinical isolates of P. aeruginosa were found to be low sensitive to amoxicillin/clavulanate (30.76%), ceftazidime (25.92%), cefoperazonum/sulbactam (46.15%), aztreonam (51.85%), tobramycin (38.46%), amicacin (70.34%), doxiciclini (26.92%), fluoroquinolones (59.26%). The analitical progistic criteria of decrease of sensitivity to ceftazidime, cefepim, meropenem and gatifloxacin were found in P. aeruginosa. This pathogen was determined to be sensitive to decasan ®, antimicrobial composition of decamethoxine ®, iodine pvidone.

Conclusions. Clinical strains of Pseudomonas aeruginosa, being highly resistant to antibiotics, are also very sensitive to antiseptics decasan ®, antimicrobial of decamethoxine®, povidone iodine.

Author Biographies

O. A. Nazarchuk, Vinnytsia National Pirogov Memorial Medical University
Department of microbiology, senior lecturer
D. V. Paliy, Vinnytsia National Pirogov Memorial Medical University
Department of Infectious diseases, Assistant Professor
N. I. Osadchuk, Vinnytsia National Pirogov Memorial Medical University
Department of microbiology, senior lecturer

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Published
2017-07-12
How to Cite
Nazarchuk, O., Paliy, D., & Osadchuk, N. (2017). RESEARCH IN SENSITIVITY TO ANTIBIOTICS, ANTISEPTICS IN PSEUDOMONAS AERUGINOSA STRAINS ISOLATED FROM PATIENTS WITH INFECTIOUS COMPLICATIONS. International Journal of Medicine and Medical Research, 3(1), 64-69. https://doi.org/10.11603/ijmmr.2413-6077.2017.1.7000