SCREENING FOR DYSLIPIDEMIA AND EXPEDIENCE OF STATIN THERAPY FOR THE CITIZENS OF TRANSCARPATHIA VALLEY REGIONS WITH OVERWEIGHT AND OBESITY
DOI:
https://doi.org/10.11603/ijmmr.2413-6077.2017.1.6879Keywords:
body mass index, overweight, obesity, lipid profile, statins.Abstract
Background. The lipid profiles of patients with overweight, obesity and healthy individuals, the citizens of Transcarpathia valley regions were analysed.
Objective. The study was aimed at evaluation of dyslipidaemia frequency in patients with overweight and obesity, determination of expedience of statins prescription.
Methods. All patients were divided into 2 groups: group 1 – patients with overweight; group 2 – patients with obesity of I and II degree. Estimation of lipid profile parameters was conducted by means of spectrophotometric device SIEMENS Dimension RxL Max. Statistical analysis of the data was conducted using Microsoft Excel 2007.
Results. The patients with obesity had higher level of total cholesterol (6.03±0.53 mmol/l), lower HDL-C (1.15±0.07 mmol/l) and higher level of LDL-C (4.19±0.46 mmol/l) compare with overweight patients.
In 46% of patients with overweight, dyslipidaemia was evidenced and required correction, 27% of them had high CVR and needed statin therapy, 19% of people with obesity had moderate CVR and didn’t need statins.
77% of obese patients needed lipid correction, 54% of them with very high and averagely high level of CVR required statin therapy; 23% of people with obesity had moderate CVR and did not need statins.
Conclusions. In the studied overweight and obese patients, atherogenic dyslipidaemia was established in 46% and 77% of cases respectively. Correction of dyslipidaemia with statin was compulsory for 27% of patients with overweight and for 54% with obesity.
References
Obesity: world statistic. 2015. https://medaboutme.ru/zdorove/publikacii/stati/sovety_vracha/ozhirenie_mirovaya_statistika/?utm_source=copypaste&utm_medium=referral&utm_campaign=copypaste?utm_source=copypaste&utm_medium=referral&utm_campaign=copypaste. Accessed 31 June 2015.
NCD Risk Factor Collaboration (Mariachiara Di Cesare, James Bentham, Gretchen A Stevens and other more than 150 authors). Trends in adult body-mass index in 200 countries from 1975 to 2014: a pooled analysis of 1698 population-based measurement studies with 19·2 million participants. Lancet. 2016;387:1377–96.
Frühbeck G, Toplak H, Woodward E, Yumuk V, Maislos M, Oppert JM. Obesity: The Gateway to ill Health – an EASO position statement on a rising public health, clinical and scientific challenge in Europe. Obes. Facts. 2013;6:117–120.
Zhang J, Shi XM, Liang XF. Economic costs of both overweight and obesity among Chinese urban and rural residents, in 2010. Zhonghua Liu Xing Bing XueZaZhi. 2013;34(6):598–600.
Magkos F, Mohammed BS, Mittendorfer B. Effect of obesity on the plasma lipoprotein subclass profile in normoglycemic and normolipidemic men and women. Int J Obes. 2008;32 (11):1655–1664.
Rosolova H, Nussbaumerova B. Cardio-metabolic risk prediction should be superior to cardiovascular risk assessment in primary prevention of cardiovascular diseases. EPMA J. 2011;2(1):15–26.
Rizzo M, Mikhailidis DP. There is more to predicting vascular disease than just established risk factors. Curr Pharm Des. 2011;17(33):3608–3610.
Tvorogova M.G. Reverse cholesterol transport. Cardiology 2011;2:66–70.
Rizzo M, Kotur-Stevuljevic J, Berneis K, Spinas G, Rini GB, Jelic-Ivanovic Z, et al. Atherogenic dyslipidaemia and oxidative stress: A new look Transl Res. 2009;153(5):217–223.
Sokolova E.I Decrease of the importance of antiatherogenic high-density lipoproteins in obese. Cardilogy. 2010;2:45–50.
Downloads
Published
How to Cite
Issue
Section
License
Authors who sent their manuscript to International Journal of Medicine and Medical Research agree to the following terms:
1. Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License CC-BY-NC that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
2. Authors able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
3. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
