PATHOGENETIC MECHANISMS OF LUNG INJURY
Background. In contemporary life science research development most attention is paid to mechanisms of many human diseases that are associated with the violation in cell death. One of the main causes of cell thanatologic disregulation program is the changes in their production and activation of the biological effects of tumor alpha necrosis factor.
Objective is to summarize current scientific data about role of activated oxygen and nitric metabolites in the system of lung pathogenetic injuries.
Methods: analysis of the research data on mechanisms of lung injury.
Results and conclusions. The topical issue of lung pathogenetic injury is to understand the signs and mechanisms responsible for regulation of free radical oxidation and antioxidant defense system, the role of pro- and anti-inflammatory molecules, the influence of active metabolites on the process of restoration and survival of the respiratory tract cells in cases of acute lung injury. The studies of this processes will help to obtain more knowledge on lung pathology.
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